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Hydrogel paste and preparation method thereof

The technology of a hydrogel patch and a hydrogel layer is applied in the field of hydrogel patch and its preparation, which can solve the problems of short action time, poor sustained-release effect, instability and the like of the hydrogel patch, so as to improve the sustained-release performance. , strong antioxidant properties, prolong the effect of the action time

Active Publication Date: 2012-08-08
佛山拜澳生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a hydrogel patch and its preparation method, which aims to solve the problems of the existing hydrogel patch such as short action time, poor slow-release effect, instability and easy oxidation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Prepare the following substances by mass percentage:

[0055] Whitening agent: zinc glycyrrhizinate 0.03, glycyrrhizic acid 0.1% Cross-linking regulator: disodium edetate 0.08% Polymer skeleton material: polyvinyl alcohol 4% Acid-base regulator: tartaric acid 0.55% Tackifier: Polyvinylpyrrolidone 1.5% Humectant: Propylene Glycol 6% Filler: ceramic clay 0.5% Preservative: Methyl Chlorisothiazolinone 0.03% Cross-linking agent: glutaraldehyde 0.1% Distilled water: balance

[0056] Step 1: The polymer skeleton material is swollen with distilled water, and whitening agent, thickener, moisturizer, and filler are added;

[0057] Step 2: Dissolve the cross-linking agent, cross-linking regulator, acid-base regulator, and preservative in an appropriate amount of distilled water, and add the swollen polymer skeleton material

[0058] Step 3: mixing the above-mentioned components to prepare a hydrogel patch matrix;

[0059] Step 4: After ...

Embodiment 2

[0064] Whitening agent: dipotassium glycyrrhizinate 0.1% Cross-linking regulator: disodium edetate 0.5% Polymer skeleton material: sodium polyacrylate 8%, carboxypropyl methylcellulose 2% Acid-base regulator: tartaric acid 0.5% Tackifier: Polyvinylpyrrolidone 1% Humectant: Butylene Glycol 7% Filler: Kaolin 0.5% Preservative: Methyl Chlorisoxazolone 0.05% Cross-linking agent: aluminum glycinate 0.08% Distilled water: balance

[0065] Step 1: The polymer skeleton material is swollen with distilled water, and whitening agent, thickener, moisturizer, and filler are added;

[0066] Step 2: Dissolve the cross-linking agent, cross-linking regulator, acid-base regulator, and preservative in an appropriate amount of distilled water, and add the swollen polymer skeleton material

[0067] Step 3: mixing the above-mentioned components to prepare a hydrogel patch matrix;

[0068] Step 4: After coating and cutting the hydrogel patch matrix, let it...

Embodiment 3

[0073] Whitening agent: monopotassium glycyrrhizinate 0.1%, glycyrrhetinic acid 0.2% Cross-linking modifier: tetrasodium edetate 0.06% Polymer skeleton material: sodium polyacrylate 7%, carboxyethyl cellulose 3% Acid-base regulator: 0.5% gluconic acid Tackifier: Polyvinylpyrrolidone 0.8% Humectant: Glycerol 8% Filler: Diatomaceous Earth 1% Preservative: Methyl Chlorisoxazolone 0.02% Cross-linking agent: aluminum glycinate 1% Distilled water: balance

[0074] Step 1: The polymer skeleton material is swollen with distilled water, and whitening agent, thickener, moisturizer, and filler are added;

[0075] Step 2: Dissolve the cross-linking agent, cross-linking regulator, acid-base regulator, and preservative in an appropriate amount of distilled water, and add the swollen polymer skeleton material

[0076] Step 3: mixing the above-mentioned components to prepare a hydrogel patch matrix;

[0077]Step 4: After coating and cutting the hydr...

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Abstract

The invention discloses a hydrogel paste and a preparation method thereof, wherein the hydrogel paste is composed of three layers: a backing layer, a hydrogel layer and a protecting film layer. The hydrogel layer is arranged between the backing layer and the protecting film layer; the hydrogel layer comprises the following components: 5-10% of macromolecule framework material, 0.5-2% of tackifier, 0.5-1% of filler, 0.03-1% of cross-linking agent, 0.03-1% of cross-linking regulator, 0.5-1% of acid-base regulator, 3-10% of humectant, 0.01-2% of preservative and the balance of distilled water; and the hydrogel layer also comprises 0.01-10% of active ingredient, such as whitening agent, antiphlogistic agent, essential oil, and the like. The hydrogel paste has an excellent slow-release property; the action time of the hydrogel paste is prolonged; a cross-linking effect of the cross-linking agent is fully utilized, so that the hydrogel paste is excellent in viscosity and cohesive strength; and the hydrogel paste is high in oxidation resistance, is safe and free from toxic side effect and is suitable for the treatment of dry, fragile and sensitive skins.

Description

Technical field [0001] The present invention relates to the field of hydrogel patches, and in particular to a multifunctional hydrogel patch and a preparation method thereof. Background technique [0002] Hydrogel is a gel with water as the dispersion medium. Hydrogel introduces some hydrophobic groups and hydrophilic residues into a water-soluble polymer with a network structure. The hydrophilic residues combine with water molecules to connect the water molecules inside the network, and the Hydrophobic residues swell when exposed to water. It is a cross-linked polymer with a polymer network system. It is soft in nature, can maintain a certain shape, and can absorb a large amount of water. [0003] As a highly water-absorbent and high-water-retaining material, hydrogel is widely used in a variety of fields, such as facial masks, antipyretic patches, analgesic patches, agricultural films, condensation preventers in construction, humidity regulators, and petrochemical indust...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K45/00A61K47/36A61K47/32A61P31/04A61K8/02A61K8/97A61K8/63A61K8/73A61K8/81A61Q19/02A61K8/92
Inventor 黄庆
Owner 佛山拜澳生物科技有限公司
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