Porous hydroxyapatite biological ceramic and preparation method thereof

A technology of hydroxyapatite and bioceramics, applied in tissue regeneration, drug delivery, pharmaceutical formulations, etc., to achieve the effect of large compressive strength

Inactive Publication Date: 2012-08-22
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no porous hydroxyapatite bioceramic material well suited for bone tissue growth

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1) Add 100 g of deionized water, 1 g of polyacrylamide, 1 g of polyvinyl alcohol, and 5 g of hydroxyapatite powder into the ball mill tank, and after ball milling for 20 hours, water-based hydroxyapatite slurry is obtained;

[0018] 2) Fix the polyester braided net with a diameter of 185 μm on both ends of the mold, and then use a polyester thread with a diameter of 165 m to pass through the mesh holes at both ends, so that they are oriented in the mold;

[0019] 3) After injecting the water-based hydroxyapatite slurry into the mold, put it into a container filled with liquid nitrogen for low-temperature directional solidification, control the cooling rate at 5°C / min, and then freeze-dry the frozen green body in a freeze dryer ;

[0020] 4) The dried body was sintered at 1350°C, and after sintering for 1 hour, it was cooled to room temperature with the furnace temperature to obtain a porous hydroxyapatite ceramic with a pore diameter of 150 μm and a lamellar oriented po...

Embodiment 2

[0022] 1) Add 95 g of deionized water, 0.5 g of polyacrylamide, 0.5 g of polyvinyl alcohol, and 35 g of hydroxyapatite powder into the ball mill tank, and after ball milling and mixing for 30 hours, water-based hydroxyapatite slurry is obtained;

[0023] 2) Fix nylon braided nets with a diameter of 530 μm at both ends of the mold, and then use nylon wires with a diameter of 510 μm to pass through the mesh holes at both ends, so that they are oriented in the mold;

[0024] 3) After injecting the water-based hydroxyapatite slurry into the mold, put it into a container filled with liquid nitrogen for low-temperature directional solidification, control the cooling rate to 3°C / min, and then freeze-dry the frozen green body in a freeze dryer ;

[0025] 4) The dried body was sintered at 1300°C, and after sintering for 1 hour, it was cooled to room temperature with the furnace temperature to obtain a porous hydroxyapatite ceramic with a pore diameter of 500 μm and a lamellar oriented ...

Embodiment 3

[0027] 1) Add 105g of deionized water, 2g of polyacrylamide, 2g of polyvinyl alcohol, and 150g of hydroxyapatite powder into the ball mill tank, and after ball milling and mixing for 20 hours, water-based hydroxyapatite slurry is obtained;

[0028] 2) Fix the two ends of the mold with a polyester braided net with a diameter of 1060 μm, and then use a polyester thread with a diameter of 1050 μm to pass through the mesh holes at both ends, so that they are oriented in the mold;

[0029] 3) After injecting the water-based hydroxyapatite slurry into the mold, put it into a container filled with liquid nitrogen for low-temperature directional solidification, control the cooling rate to 0.5°C / min, and then freeze-dry the frozen green body in a freeze dryer ;

[0030] 4) The dried green body was sintered at 1250°C, and after sintering for 1.5 hours, it was cooled to room temperature with the furnace temperature to obtain a porous hydroxyapatite ceramic with a pore diameter of 1000 μm...

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PUM

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Abstract

The invention discloses porous hydroxyapatite biological ceramic and a preparation method thereof. The porous hydroxyapatite biological ceramic has the aperture size and distribution, porosity, hole-through condition and hole surface suitable for growth of bone tissues and is provided with macro pores capable of accommodating grown new bones, and the pore wall of the ceramic is provided with rich lamellar pores, so that the ceramic has an effect of conducting the formed bones. The preparation method comprises the following steps of: setting the orientation, the diameter and the distribution density of macromolecular fibers in a mold in advance, and freezing and solidifying water-based hydroxyapatite slurry by using a directional temperature field, so that the hydroxyapatite powder granules are gathered and rearranged under push rejection of directionally grown ice crystal; and performing freeze drying on the obtained ice blank, sublimating the ice crystal, and sintering, so that fine control of a porous micro structure can be realized. The porous hydroxyapatite prepared by using the method has high hole-through rate and high porosity, and is suitable for growth of the bone tissues.

Description

technical field [0001] The invention relates to a porous hydroxyapatite bioceramic and a preparation method thereof. Background technique [0002] At present, there is still a lack of satisfactory bone substitute materials for the repair of long bone injuries and defects caused by trauma, inflammation, and tumor resection, which has become a medical problem that needs to be solved urgently. At present, the main clinical methods for repairing long bone injuries are autologous bone transplantation, allogeneic bone, allogeneic bone transplantation and artificial bone replacement. Autologous bone grafting is the "gold standard" for the treatment of bone defects, but when repairing large bone defects, it causes damage to the donor site tissue, the amount of bone donor is limited, and complications are prone to occur, making it difficult to achieve a satisfactory therapeutic effect. Although bone allograft and allograft bone transplantation can avoid damage to the donor site tiss...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/16A61L27/12
CPCA61L27/12A61L27/50A61L27/56A61L2400/08A61L2430/02
Inventor 周科朝黄智张斗李志友张妍陈良建
Owner CENT SOUTH UNIV
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