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Cimetidine instant granules and preparation method thereof

A technology of cimetidine and granules, applied in the field of cimetidine instant granules and their preparation, can solve the problems of animal body stress response, unfavorable disease treatment, poor palatability, etc. Effect

Active Publication Date: 2012-09-12
DINGZHENG XINXING BIOTECH TIANJIN
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Cimetidine is easily soluble in methanol, dissolved in ethanol, slightly soluble in isopropanol, slightly soluble in water, easily soluble in dilute hydrochloric acid, and cimetidine has the disadvantages of bitter taste and poor palatability. , invented cimetidine injection, but its active ingredient content is only 0.4%. In clinical use, a large number of injections are needed to meet the needs of animals. irritative reaction, which is not conducive to the treatment of diseases

Method used

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  • Cimetidine instant granules and preparation method thereof
  • Cimetidine instant granules and preparation method thereof
  • Cimetidine instant granules and preparation method thereof

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preparation example Construction

[0024] The preparation method of above-mentioned cimetidine instant granule, comprises the following steps:

[0025] (1) mix cimetidine with disintegrating agent, pass through 80 mesh sieves after pulverizing;

[0026] (2) Dissolving the wetting agent in purified water;

[0027] (3) After mixing the correctives and excipients, pass through an 80-mesh sieve, then add to the product of step (1), and mix evenly;

[0028] (4) the product of step (3) is mixed with the product of step (2);

[0029] (5) Wet granulation, and then dry at 60-70 degrees Celsius to obtain the finished product.

Embodiment 1

[0031] (1) 10 grams of cimetidine are mixed with 40 grams of sucrose, crushed and passed through an 80-mesh sieve;

[0032] (2) 10 grams of polyvinylpyrrolidone and 20 grams of polyethylene glycol 6000 were dissolved in 20 milliliters of purified water;

[0033] (3) After mixing 5 grams of sodium bicarbonate, 5 grams of malic acid, and 10 grams of microcrystalline cellulose, after passing through an 80-mesh sieve, add in the product of step (1), and mix evenly;

[0034] (4) the product of step (3) is mixed with the product of step (2);

[0035] (5) Wet granulation, after drying, sizing and packaging, the finished product is obtained.

[0036] The active ingredient content of the prepared cimetidine instant granule is: 10%.

Embodiment 2

[0038] (1) 15 grams of cimetidine are mixed with 35 grams of soluble starch, crushed and passed through an 80-mesh sieve;

[0039] (2) 20 grams of tartaric acid and 10 grams of polyvinylpyrrolidone are dissolved in 20 milliliters of purified water;

[0040] (3) After mixing 5 grams of sodium bicarbonate, 5 grams of fruit flavor, and 10 grams of microcrystalline cellulose, after passing through an 80-mesh sieve, add it to the product of step (1), and mix evenly;

[0041] (4) the product of step (3) is mixed with the product of step (2);

[0042] (5) Wet granulation, after drying, sizing and packaging, the finished product is obtained.

[0043] The active ingredient content of the prepared cimetidine instant granule is: 15%.

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Abstract

The invention relates to cimetidine instant granules comprising following mixed components, by weight, 10-20 parts of cimetidine, 30-40 parts of disintegrant, 20-40 parts of humectant, 2-10 parts of corrective and 10-20 parts of excipient. The cimetidine instant granules are prepared by mixing the cimetidine, the disintegrant, the humectant and the excipient. Evidenced by experiments, the cimetidine instant granules have the advantages of high stability, good taste, edible easiness for animals, convenience in utilization and good therapeutic effect, can be stored for a long time, and has effective amount higher than that of existing injection.

Description

technical field [0001] The invention relates to the technical field of preparation of cimetidine medicaments, in particular to a cimetidine instant granule and a preparation method thereof. Background technique [0002] Cimetidine (N'-methyl-N"-[2[[(5-methyl-1H-imidazol-4-yl)methyl]thio]-ethyl]-N-cyanoguanidine), White or off-white crystalline powder, almost odorless, bitter in taste, it has the effect of inhibiting gastric acid secretion, prevents and protects corrosive gastritis caused by chemical stimulation, and also has effect on stress gastritis and upper gastrointestinal bleeding Obvious curative effect. [0003] Cimetidine is easily soluble in methanol, dissolved in ethanol, slightly soluble in isopropanol, slightly soluble in water, easily soluble in dilute hydrochloric acid, cimetidine has the disadvantages of bitter taste and poor palatability, people have studied , invented cimetidine injection, but its active ingredient content is only 0.4%. In clinical use, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/4164A61P1/04
Inventor 董惠峰刘鼎阔王立红张勇张俊霞张凤洪
Owner DINGZHENG XINXING BIOTECH TIANJIN
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