Nifuroxazide microcapsule powder and production method thereof
The technology of nifuryl hydrazide microcapsule powder and nifuryl hydrazide is applied in the field of veterinary drug manufacture and animal feed additives, and can solve the problems of application effect and expansion of application scope restriction, low dissolution rate, influence on drug effect and the like, To achieve the effect of favorable absorption and medication effect, adsorption and uniformity improvement, and good feeding effect
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Embodiment 1
[0023] Take 1kg of Nifuran hydrazide and smash it through a 600-mesh sieve to obtain nitrofuran hydrazide fine powder for later use; Take 0.01 kg of Nifuran hydrazide and dissolve with 2 kg of 95% ethanol to make an ethanol solution of Nifuran sulfonic acid; Put the above-mentioned nitrofuranol hydrazide powder in a mixer, add cyclohexane sulfonic acid ethanol solution, stir evenly, then add 2kg 1000 mesh silica powder, fully stir evenly, pass a 200 mesh sieve to make the sac core; Put the capsule core into a stainless steel jacketed pot with a stirring device, add 4kg polyethylene glycol 4000 and stir evenly, heat the compartment at 75℃~80℃ to melt and stir evenly, then pour it into the metal plate in the ice water bath immediately After it is rapidly cooled and solidified, it is placed in a desiccator to dry for 24 hours, and crushed with a jet mill to make powder with a particle size of 90-100 mesh, which is the finished nitrofurol hydrazide microcapsule powder.
Embodiment 2
[0025] Take 1kg of Nifuran hydrazide and smash it through a 600-mesh sieve to obtain nitrofuran hydrazide fine powder for later use; Take 0.015 kg of Nifuran hydrazide and dissolve with 2 kg of 95% ethanol to make an ethanol solution of Nifuran; Put the above-mentioned nitrofuranol hydrazide powder in a mixer, add cyclohexane sulfonic acid ethanol solution, stir evenly, then add 1kg 1000 mesh silica powder, fully stir evenly, pass a 200 mesh sieve to make the sac core; Put the capsule core into a stainless steel jacketed pot with a stirring device, add 3kg of polyethylene glycol 6000 and stir evenly, heat the interlayer at 75℃~80℃ to melt and stir evenly, then pour it into the metal plate in the ice water bath immediately After being rapidly cooled and solidified, it is placed in a desiccator to dry for 24 hours, and crushed with a jet mill to make powder with a particle size of 90-100 mesh, which is the finished nifurol hydrazide microcapsule powder.
Embodiment 3
[0027] Take 1kg of Nifuran hydrazide and smash it through a 600-mesh sieve to obtain nitrofuran hydrazide fine powder for later use; Take 0.02 kg of Nifuran hydrazide and dissolve it with 2 kg of 95% ethanol to make an ethanol solution of Nifuran sulfonic acid; Place the above-mentioned nitrofuran hydrazide powder in a mixer, add cyclohexane sulfonic acid ethanol solution, stir evenly, then add 3 kg of 1100 mesh silica powder, stir well, pass through a 200 mesh sieve to make the sac core; Put the capsule core into a stainless steel jacketed pot with a stirring device, add 6kg of polyethylene glycol 6000 and stir evenly, heat the interlayer at 75℃~80℃ to melt and stir it evenly, then pour it onto the metal plate in the ice water bath immediately After it is rapidly cooled and solidified, it is placed in a desiccator to dry for 24 hours, and crushed with a jet mill to make powder with a particle size of 90-100 mesh, which is the finished nitrofurol hydrazide microcapsule powder.
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