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Preparation method of ruthenium complex-silica nanoparticles

A technology of silica and nanoparticles, applied in chemical instruments and methods, nanotechnology, nano-optics, etc., can solve problems such as troublesome surface functionalization of fluorescent silica nanoparticles, and achieve good monodispersity and high fluorescence intensity , size controllable effect

Inactive Publication Date: 2012-09-12
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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Problems solved by technology

However, the functionalization of the surface of fluorescent silica nanoparticles prepared by this method is cumbersome, and the particle surface must be aminated by 3-aminopropyltrimethoxysiloxane or 3-aminopropyltriethoxysiloxane , and then react in a saturated ethanol solution of succinic anhydride to make the particle surface with carboxyl groups

Method used

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  • Preparation method of ruthenium complex-silica nanoparticles
  • Preparation method of ruthenium complex-silica nanoparticles
  • Preparation method of ruthenium complex-silica nanoparticles

Examples

Experimental program
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Embodiment 1

[0026] combine figure 1 The production flow of this embodiment is illustrated as shown.

[0027] Step 1: Dissolve an appropriate amount of tris(disulfonic acid-4,7-diphenyl-phenanthroline) ruthenium (II) tetrasodium salt (RuBPS) in deionized water to prepare a negatively charged metal ruthenium complex An aqueous solution of RuBPS with a concentration of 5.5 mg / ml.

[0028] Step 2: Take 7.5ml of cyclohexane (analytical pure), 1.806ml of Triton X-1006ml with a concentration of 0.1mol / L, and 2.64ml of n-hexanol (analytical pure) as the dispersed phase, surfactant and co-surfactant respectively Add it into the reaction flask and stir evenly to form a mixed system.

[0029] Step 3: Add 100 ul of a polyethyleneimine (PEI) aqueous solution with a concentration of 29 mmol / L to the above system, and stir at a constant speed for 0.5 hours. Then add 0.1 ml of the above-mentioned RuBPS aqueous solution, and stir well. Among them, PEI serves as a catalyst to provide a positive center ...

Embodiment 2

[0033] Step 1: Dissolve an appropriate amount of RuBPS in deionized water to prepare an aqueous solution containing negatively charged metal ruthenium complex RuBPS at a concentration of 5.5 mg / ml.

[0034] Step 2: Take 7.5ml of cyclohexane (analytical pure), 1.806ml of Triton X-1006ml with a concentration of 0.1mol / L, and 2.64ml of n-hexanol (analytical pure), respectively as the dispersed phase, surfactant, and cosurfactant in sequence Add to the reaction bottle and stir well. Wherein, the ratio of the amount of the surfactant to the co-surfactant is preferably controlled between 2.7 and 8.

[0035] Step 3: Add 100 ul of PEI aqueous solution with monomer amine concentration of 58 mmol / L to the above system, and stir at a constant speed for 0.5 hour. Then add 0.1 ml of the above-mentioned RuBPS aqueous solution, and stir well. Among them, PEI serves as a catalyst to provide a positive center to adsorb the negatively charged fluorescent molecule RuBPS, so that it can be embe...

Embodiment 3

[0039] In this example, other steps and the amount of reactants used are consistent with Example 1, except that the concentration of PEI monomer is 0 mmol / L. Finally, RuBPS-silica nanoparticles (A0) with amino groups were obtained.

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Abstract

The invention provides a preparation method of ruthenium complex-silica nanoparticles. The preparation method comprises the following steps of orderly adding cyclohexane, Triton X-100 and hexanol into a reaction flask, stirring to obtain a mixed system, adding polyethyleneimine into the mixed system, stirring for at least 0.5 hours, adding a ruthenium complex solution into the mixed system according to a mole ratio of a ruthenium complex to polyethyleneimine monomers of 1: (878-1758), stirring, orderly adding tetraethoxysilane and ammonia water into the mixed system, stirring, carrying out a reaction with stirring for 12 hours, after the reaction is finished, carrying out centrifugation, removing supernatant, carrying out washing precipitation by ethanol, and carrying out ultrasonic dispersion to obtain a dispersion liquid of the ruthenium complex-silica nanoparticles with amino groups. The preparation method is convenient for operation. The ruthenium complex-silica nanoparticles obtained by the preparation method have good monodispersity and high fluorescence intensity and are convenient for surface functional operation.

Description

technical field [0001] The invention belongs to the technical field of luminescent nanometer materials, and in particular relates to a method for preparing silicon dioxide nanoparticles containing negatively charged metal complexes. Background technique [0002] Silica nanoparticles have broad application prospects in the field of biological detection due to their good biocompatibility, easy surface functionalization and easy preparation. The application of dye-doped silica nanoparticles in the field of biological detection has attracted much attention, mainly as markers of tissue cells or biomolecules for biological detection. The advantage of fluorescent silica nanoparticles is that the silica particles encapsulated with dyes are enriched with a large amount of fluorescent dyes, showing strong photosensitivity and high photostability, and have good water solubility, easy surface modification and easy synthesis. specialty. At the same time, compared with the toxicological...

Claims

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Application Information

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IPC IPC(8): C09K11/59C09K11/06B82Y30/00B82Y20/00
Inventor 贾俊丽费浩吕志成周明
Owner SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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