Preparation method of ruthenium complex-silica nanoparticles

A technology of silica and nanoparticles, applied in chemical instruments and methods, nanotechnology, nano-optics, etc., can solve problems such as troublesome surface functionalization of fluorescent silica nanoparticles, and achieve good monodispersity and high fluorescence intensity , size controllable effect

Inactive Publication Date: 2012-09-12
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the functionalization of the surface of fluorescent silica nanoparticles prepared by this method is cumbersome, and the particle surface must be aminated by 3-aminopro

Method used

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  • Preparation method of ruthenium complex-silica nanoparticles
  • Preparation method of ruthenium complex-silica nanoparticles
  • Preparation method of ruthenium complex-silica nanoparticles

Examples

Experimental program
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Example Embodiment

[0025] Example 1

[0026] Combine figure 1 The production process of this embodiment is shown and explained.

[0027] Step 1: Dissolve an appropriate amount of tris(disulfonic acid-4,7diphenyl o-phenanthroline) ruthenium (II) tetrasodium salt (RuBPS) in deionized water to prepare a negatively charged metal ruthenium complex An aqueous solution of RuBPS with a concentration of 5.5 mg / ml.

[0028] Step 2: Take 7.5ml of cyclohexane (analytical purity), 1.806ml of Triton X-100 with a concentration of 0.1mol / L, and 2.64ml of n-hexanol (analytical purity) as the dispersed phase, surfactant, and co-surfactant respectively. Add to the reaction flask and stir evenly to form a mixed system.

[0029] Step 3: Add 100 ul of polyethyleneimine (PEI) aqueous solution with a concentration of 29 mmol / L of monomers to the above system, and stir at a uniform speed for 0.5 hours. Then add 0.1 ml of the above RuBPS aqueous solution and stir evenly. Among them, PEI serves as a catalyst to provide a posit...

Example Embodiment

[0032] Example 2

[0033] Step 1: Take an appropriate amount of RuBPS and dissolve it in deionized water to prepare an aqueous solution containing a negatively charged metal ruthenium complex RuBPS with a concentration of 5.5 mg / ml.

[0034] Step 2: Take 7.5ml of cyclohexane (analytical purity), 1.806ml of Triton X-100 with a concentration of 0.1mol / L, and 2.64ml of n-hexanol (analytical purity), respectively, as the dispersed phase, surfactant, and co-surfactant in sequence Add to the reaction flask and stir well. Among them, the ratio of the amount of surfactant to co-surfactant is preferably controlled between 2.7 and 8.

[0035] Step 3: Add 100ul of PEI aqueous solution with a monomer amine concentration of 58mmol / L to the above system, and stir at a uniform speed for 0.5 hours. Then add 0.1 ml of the above RuBPS aqueous solution and stir evenly. Among them, PEI serves as a catalyst to provide a positive electric center to adsorb the negatively charged fluorescent molecule RuB...

Example Embodiment

[0038] Example 3

[0039] In this example, the other steps and the amount of reactants are the same as in Example 1, except that the amount of the PEI monomer is 0 mmol / L. Finally, RuBPS-silica nanoparticles (A0) with amino groups were obtained.

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Abstract

The invention provides a preparation method of ruthenium complex-silica nanoparticles. The preparation method comprises the following steps of orderly adding cyclohexane, Triton X-100 and hexanol into a reaction flask, stirring to obtain a mixed system, adding polyethyleneimine into the mixed system, stirring for at least 0.5 hours, adding a ruthenium complex solution into the mixed system according to a mole ratio of a ruthenium complex to polyethyleneimine monomers of 1: (878-1758), stirring, orderly adding tetraethoxysilane and ammonia water into the mixed system, stirring, carrying out a reaction with stirring for 12 hours, after the reaction is finished, carrying out centrifugation, removing supernatant, carrying out washing precipitation by ethanol, and carrying out ultrasonic dispersion to obtain a dispersion liquid of the ruthenium complex-silica nanoparticles with amino groups. The preparation method is convenient for operation. The ruthenium complex-silica nanoparticles obtained by the preparation method have good monodispersity and high fluorescence intensity and are convenient for surface functional operation.

Description

technical field [0001] The invention belongs to the technical field of luminescent nanometer materials, and in particular relates to a method for preparing silicon dioxide nanoparticles containing negatively charged metal complexes. Background technique [0002] Silica nanoparticles have broad application prospects in the field of biological detection due to their good biocompatibility, easy surface functionalization and easy preparation. The application of dye-doped silica nanoparticles in the field of biological detection has attracted much attention, mainly as markers of tissue cells or biomolecules for biological detection. The advantage of fluorescent silica nanoparticles is that the silica particles encapsulated with dyes are enriched with a large amount of fluorescent dyes, showing strong photosensitivity and high photostability, and have good water solubility, easy surface modification and easy synthesis. specialty. At the same time, compared with the toxicological...

Claims

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Application Information

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IPC IPC(8): C09K11/59C09K11/06B82Y30/00B82Y20/00
Inventor 贾俊丽费浩吕志成周明
Owner SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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