Medical hot melt pressure sensitive adhesive substrate and preparation method thereof

Abstract

The invention discloses a medical hot melt pressure sensitive adhesive substrate and a preparation method thereof, and belongs to the technical field of hot melt adhesives. According to the hot melt pressure sensitive adhesive substrate, 40 to 60 weight parts of epoxidation modified styrene-dialkene-styrene block copolymer thermoplastic elastomer is taken as a main body, partial double bonds of the copolymer are converted into epoxide groups, 30 to 70 weight parts of tackifier, 30 to 60 weight parts of plasticizer and 1 to 10 weight parts of antioxidant are added, and a hot melt pressure sensitive adhesive is prepared and is stirred to be fused under the protection of nitrogen. The hot melt pressure sensitive adhesive is transparent, high in polarity and medicine-loading rate, has moisture-penetrability, is attached to skin to ensure that the skin is comfortable, and contains 100 percent of solid content without solvent.

Description

technical field [0001] The invention belongs to the technical field of hot-melt adhesives, and in particular relates to a medical hot-melt pressure-sensitive adhesive matrix and a preparation method. Background technique [0002] Hot-melt pressure-sensitive adhesives can produce excellent hot tack at moderately high temperatures, are solid at room temperature, and can produce good bonding effects with fingers or light pressure. [0003] Compared with ordinary hot-melt pressure-sensitive adhesives, medical hot-melt pressure-sensitive adhesives are in direct contact with the skin, so they must have the requirements of hypoallergenicity, good moisture permeability, moderate adhesion, and high drug loading. [0004] The medical hot-melt pressure-sensitive adhesives in the prior art mainly use rubber / tackifier / plasticizer as the skeleton material, and the rubber matrix generally adopts natural rubber or styrene-diene-styrene block copolymer thermoplastic elastomer Class, Chinese...

AI Technical Summary

Problems solved by technology

[0004] The medical hot-melt pressure-sensitive adhesives in the prior art mainly use rubber / tackifier / plasticizer as the skeleton material, and the rubber matrix generally adopts natural rubber or styrene-diene-styrene block copolymer thermoplastic elastomer Class, Chinese patent CN1800289 proposes the use of styrene-isoprene-styrene (SIS) and tackifiers and plasticizers to make hot-melt pressure-sensitive adhesives for medical pressure-sensitive adhesive substrates, but whether it is natural rubber Polymers or styrene-diene-styrene block copolymer thermoplastic elastomers are non-polar materials with poor moisture absorption and perspiration, while commonly used traditional Chinese medicine preparations are mostly extracted with ethanol or water, and the extracted components are more polar , which is quite different from the existing matrix and skeleton materials in polarity, which will directly affect the drug loading and release rate of the preparation, and will inevitably seriously affect the curative effect of the preparation

In addition, the Chinese patent CN1152470A uses a hot-melt acrylate pressure-sensitive adhesive. Since the conversion rate of this type of pressure-sensitive adhesive cannot reach 100% during the polymerization of acrylate monomers, the existence of residual monomers is inevitable, causing the product to be harmful to the human body. cause irritation and injury