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Microzyme for degrading residual lincomycin in fermented leaves and application thereof

A technology of lincomycin and yeast strains, applied in the direction of fungi, microorganism-based methods, microorganisms, etc., can solve the problems of refractory degradation, low extraction purity, environmental pollution, etc., achieve high efficiency and practicability, and facilitate industrial production , the effect of rapid growth

Inactive Publication Date: 2012-09-19
NANYANG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the process of using microbial fermentation to produce lincomycin, due to problems such as low extraction purity, high residual lincomycin content in the waste residue, refractory degradation and many other problems, resulting in serious environmental pollution, it is difficult to meet direct utilization or discharge standards

Method used

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  • Microzyme for degrading residual lincomycin in fermented leaves and application thereof
  • Microzyme for degrading residual lincomycin in fermented leaves and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Inoculate the galactomyces S9 strain on the slant of test tube agar medium, the medium formula is: 1% yeast powder, 2% peptone, 2% glucose; pH value 3-6. Inoculate the galactomyces S9 strain on the culture medium, and culture it at 20-30° C. for 2-5 days to obtain test-tube species.

[0048]Inoculate the test tube seeds into 250ml Erlenmeyer flask liquid culture medium (each bottle contains 100ml), the formula of liquid medium is: 1% yeast extract; 2% peptone; 2% glucose; pH3~6, the rest is water. Inoculate the test tube seeds into 500ml Erlenmeyer flask liquid culture medium, fill each bottle with 200ml, and culture on a shaking table at 20-30°C for 2-5 days, with a rotation speed of 200-300 rpm. The liquid fermentation culture of the strain is the culture liquid capable of degrading lincomycin.

Embodiment 2

[0050] It is basically the same as Example 1, except that the formula of the liquid medium is: 0.2% yeast extract; 0.5% peptone; 0.1% glucose.

Embodiment 3

[0052] Basically the same as Example 1, the difference is the liquid culture medium formula, and its formula is: 0.5% yeast extract; 1% peptone; 1% glucose.

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Abstract

The invention discloses a yeast strain, which is of a galactomyces geotrichum S9 strain. The galactomyces geotrichum S9 strain is collected in China General Microbiological Culture Collection Center on March 5, 2012, the collection and registration number is CCTCC M2012056, the galactomyces geotrichum S9 strain can degrade lincomycin and is derived from a certain metabolite component in a fermentation solution of the strain, and the main action mechanism is that the certain metabolite component generated by the strain can produce action on a certain key chemical bond in the structure of the lincomycin and further degrade the lincomycin into small molecular substances. Simultaneously, the galactomyces geotrichum S9 strain can grow rapidly under the culture conditions described by the invention, industrial production is easy to perform, the galactomyces geotrichum S9 strain has great application and development prospects, and the galactomyces geotrichum S9 strain has high efficiency and practicality when the galactomyces geotrichum S9 is used for treating the fermented leaves of streptomyces lincolnensis.

Description

technical field [0001] The invention belongs to the technical field of treating drug waste residue and feed protein with microbial strains, and in particular relates to a yeast for degrading residual lincomycin in fermented drug residue and its application. Background technique [0002] "Super bacteria" is the product of the game between bacteria and antibiotics. While antibiotics kill bacteria, they also allow some undead bacteria to evolve continuously, resulting in drug resistance. The more antibiotics are used, the stronger the drug resistance of bacteria. According to the survey, 60% of patients in our country use antibiotics on their own initiative, and only a few will seek help from doctors. Studies have shown that after antibiotics are ingested, except for a small part of them remaining in the body, more than 85% are excreted in the form of original drugs and metabolites through the feces and urine of patients and animals, and the residual antibiotics enter the soil,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/16A62D3/02C12R1/645A62D101/28
Inventor 牛秋红和晶亮唐悦沈艳丽张林丁锋张清会
Owner NANYANG NORMAL UNIV
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