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Method for preparing hydroxyapatite nanocrystals or microcrystals by using plant as template

A hydroxyapatite and nanocrystal technology, applied in the field of material chemistry, can solve problems such as unreported and unreported hydroxyapatite particles, and achieve the effects of easy removal, industrialization promotion, and increased specific surface area.

Inactive Publication Date: 2014-04-02
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] (1) There is no report of using plants as templates to prepare hydroxyapatite particles that can assemble into plant-specific microstructures;
[0009] (2) It has been reported in the literature that rod-shaped and shell-shaped hydroxyapatite can be obtained by controlling the calcination temperature, but there is no report to obtain rod-shaped hydroxyapatite nanocrystals and sheet-shaped hydroxyphosphorus by selecting templates and adjusting the calcination time and calcination temperature. Limestone nanocrystals or spherical hydroxyapatite microcrystals, in which the hydroxyapatite assembled by rod-shaped nanocrystals has a special microstructure of the template plant

Method used

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  • Method for preparing hydroxyapatite nanocrystals or microcrystals by using plant as template
  • Method for preparing hydroxyapatite nanocrystals or microcrystals by using plant as template
  • Method for preparing hydroxyapatite nanocrystals or microcrystals by using plant as template

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1: The method for preparing hydroxyapatite nanocrystals or microcrystals using plants as a template is as follows:

[0044] (1) Dissolve diammonium hydrogen phosphate in deionized water, stir to completely dissolve it into a uniform transparent solution, add cotton as a plant template, and dissolve 0.05 moles of diammonium hydrogen phosphate per liter of deionized water, per liter of phosphate Add 1g of plant template to the solution;

[0045] (2) Stir the phosphate solution at 400 rpm, and place it in an oil bath at 25°C for 24 hours. While the oil bath is constant, add calcium carbonate to the phosphate solution while stirring. The constant temperature is over After that, continue to stir for 30 minutes, then sonicate for 15 minutes, and finally cool to room temperature naturally, where the molar ratio of Ca:P is 1.67, and the pH of the solution is maintained at 8 (adjust the pH with sodium hydroxide);

[0046] (3) Filter the liquid obtained in step (2), collect th...

Embodiment 2

[0049] Example 2: The method for preparing hydroxyapatite nanocrystals or microcrystals using plants as a template is as follows:

[0050] (1) Dissolve sodium phosphate in deionized water, stir to make it completely dissolve into a uniform transparent solution, add cotton as a plant template; in which 0.1 mole of sodium phosphate is dissolved per liter of deionized water, and 3g per liter of phosphate solution is added (2) Stir the phosphate solution at 450 rpm and place it in an oil bath at a constant temperature of 50°C for 9 hours. While the oil bath is at a constant temperature, add calcium carbonate while stirring the phosphate solution After the constant temperature is over, continue to stir for 45 minutes, then ultrasonic for 30 minutes, and finally cool to room temperature naturally, where the molar ratio of Ca:P is 1.67, and the pH value of the solution is maintained at 8.5 (the pH value is adjusted with potassium hydroxide);

[0051] (3) Filter the liquid obtained in ste...

Embodiment 3

[0054] Example 3: The method for preparing hydroxyapatite nanocrystals or microcrystals using plants as a template is as follows:

[0055] (1) Dissolve sodium monohydrogen phosphate in deionized water, stir to make it completely dissolve into a uniform transparent solution, add cotton to it as a plant template; among them, dissolve 1 mole of sodium monohydrogen phosphate per liter of deionized water, per liter of phosphate Add 6g of cotton template to the solution;

[0056] (2) Stir the phosphate solution at 800rpm, and place it in an oil bath at 45℃ for 18h. While the oil bath is constant, the calcium nitrate solution is dripped at a speed of 5ml / min while stirring. Add the phosphate solution, after the constant temperature is over, continue to stir for 30 minutes, then sonicate for 25 minutes, and finally cool to room temperature naturally, where the molar ratio of Ca:P is 1.67, and the pH value of the solution is maintained at 10 (adjust the pH value with ammonia);

[0057] (3) ...

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Abstract

The invention discloses a method for preparing hydroxyapatite nanocrystals or microcrystals by using a plant as a template. In the method, soluble phosphate and a calcium salt are used as raw materials for synthesis by using a coprecipitation method, and rodlike, flaky or spherical nanocrystals or microcrystals can be obtained under triple regulation of calcination temperature, calcination time and plant template, wherein hydroxyapatite formed from the rodlike nanocrystals has the special microstructure of the template plant. The hydroxyapatite material with the special microstructure of the plant, prepared according to the invention, has meso pores and larger specific surface area. The hydroxyapatite prepared with the method has excellent physical and chemical properties and has extensive application prospect in the fields of environment-friendly materials, controlled drug release and the like. The raw materials used in the method are cheap and readily available, and the preparation process of the materials is simple and is friendly to the environment.

Description

technical field [0001] The invention specifically relates to a method for preparing hydroxyapatite nanocrystals or microcrystals by using plants as templates, and belongs to the field of material chemistry. Background technique [0002] Hydroxyapatite, also known as hydroxyapatite, has the molecular formula Ca 10 (PO 4 ) 6 (OH) 2 , is a class of widely used bioactive ceramic materials. Because its composition is similar to the inorganic composition of biological body bones, it has attracted widespread attention. With the continuous improvement of people's understanding, many research results have shown that hydroxyapatite is a non-toxic, non-carcinogenic, non-side effect and bioactive material with good biocompatibility, which can guide the growth of new bone after implantation in the body It is also found that hydroxyapatite has solid basic properties and strong ion exchange capacity, so it has been widely used in the field of catalytic carriers and ion exchange; at th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32B82Y40/00
Inventor 潘学军沈秋莹罗利军
Owner KUNMING UNIV OF SCI & TECH
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