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Silymarin phospholipid compound, mask containing same and preparation method of same

A technology of silymarin phospholipids and silymarin, which is applied in the field of daily chemical industry, can solve the problems of affecting application, low bioavailability, and poor water solubility of silymarin, and achieve the effect of enhancing cosmetic effect, high bioavailability, and improving bioavailability

Active Publication Date: 2012-11-14
惠州市九惠药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor water solubility of silymarin, its local bioavailability is low in external application on the skin, which affects its application in cosmetics.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A silymarin phospholipid complex is prepared by the following preparation method:

[0027] Suspend 45 parts of silymarin in 170 parts of ethanol, add 50 parts of soybean lecithin, heat at 50°C for 0.5h, recover ethanol under reduced pressure, and dry.

[0028] The facial mask formulated with the above-mentioned silymarin phospholipid complex consists of the following components by mass percentage:

[0029] Silymarin Phospholipid Complex 5%, Polyvinyl Alcohol-1788 10%, Sodium Carboxymethylcellulose 5%, Vitamin E 1%, Glycerin 5%, Zinc Oxide 0.5%, Fragrance 0.5%, Ethyl Paraben 1%, deionized water to 100%; the silymarin phospholipid complex powder is a powder obtained after the silymarin phospholipid complex is pulverized and sieved. The preparation method of this mask is:

[0030] (1) Add polyvinyl alcohol-1788 and sodium carboxymethyl cellulose into deionized water, stir in a water bath at 85°C to make it swell.

[0031] (2) Add glycerin, ethylparaben, vitamin E, zinc ...

Embodiment 2

[0034] The silymarin phospholipid complex is prepared by the following preparation method:

[0035] Suspend 55 parts of silymarin in 200 parts of ethanol, add 61 parts of soybean lecithin, heat at 60°C for 1 hour, recover ethanol under reduced pressure, and dry.

[0036] The facial mask formulated with the above-mentioned silymarin phospholipid complex consists of the following components by mass percentage:

[0037] Silymarin phospholipid complex powder 15%, polyvinyl alcohol-1788 20%, sodium carboxymethylcellulose 7%, vitamin E 3%, glycerin 10%, zinc oxide 1%, fragrance 0.7%, ethylparaben 1.3% , deionized water to 100%; the silymarin phospholipid complex powder is the powder obtained after the silymarin phospholipid complex is crushed and sieved.

[0038] The preparation method of this mask is:

[0039] (1) Add polyvinyl alcohol-1788 and sodium carboxymethylcellulose into deionized water, stir in a water bath at 90°C to make it swell.

[0040] (2) Add glycerin, ethylparab...

Embodiment 3

[0048] The silymarin phospholipid complex is prepared by the following preparation method:

[0049] Suspend 65 parts of silymarin in 230 parts of ethyl acetate, add 70 parts of soybean lecithin, heat at 70°C for 1.5h, recover ethyl acetate under reduced pressure, and dry.

[0050] The facial mask formulated with the above-mentioned silymarin phospholipid complex consists of the following components by mass percentage:

[0051] Silymarin phospholipid complex powder 25%, polyvinyl alcohol-1788 30%, sodium carboxymethylcellulose 10%, vitamin E 5%, sorbitol 15%, zinc oxide 1.5%, fragrance 1%, propylparaben 1.5% %, deionized water to 100%; the silymarin phospholipid complex powder is the powder obtained after the silymarin phospholipid complex is pulverized and sieved.

[0052] The preparation method of this mask is:

[0053] (1) Add polyvinyl alcohol-1788 and sodium carboxymethylcellulose into deionized water, stir in a water bath at 95°C to make it swell.

[0054] (2) Add sorb...

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Abstract

The invention belongs to the field of daily-use chemical industry, and in particular relates to a silymarin phospholipid compound, a mask prepared from the silymarin phospholipid compound and a preparation method of the silymarin phospholipid compound. The silymarin phospholipid compound is prepared by suspending silymarin in an organic solvent compatible with the silymarin, adding soybean phospholipid and heating for a period of time, reducing the pressure for recovering the organic solvent and drying. The silymarin phospholipid compound mask is prepared from silymarin phospholipid compound powder, polyvinyl alcohol-1788, sodium cellulose glycolate, vitamin E, humectant, zinc oxide, essence, preservative and deionized water. The silymarin phospholipid compound mask based on silymarin hasa stronger effect on eliminating free radicals and a stronger antioxidation effect, takes the silymarin phospholipid compound as the raw material for preparing a mask for delaying skin aging, and hasthe characteristics of good water solubility and high bioavailability compared with other silymarin cosmetics.

Description

technical field [0001] The invention belongs to the field of daily chemical industry, and particularly relates to a silymarin phospholipid complex, and also relates to a facial mask prepared from the silymarin phospholipid complex and a preparation method of the facial mask. Background technique [0002] Milk thistle is the dry ripe fruit of Silybum marianum (L.) Gaertn., a plant of Compositae. Silymarin is its main active ingredient. Studies have shown that silymarin has anti-hepatic fibrosis, anti-tumor, anti-inflammatory effects, and has strong free radical scavenging and anti-oxidation effects. [0003] In cosmetic applications, silymarin can resist oxidation and scavenge free radicals; it can be used to prevent skin aging and the stimulation of external radiation on the skin; it can also be used as an epidermal barrier strengthening agent and sebum secretion inhibitor; it can promote the formation of the extracellular matrix of the dermis The main proteins produced are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/81A61K8/55A61K8/49A61Q19/08A61Q19/02A61Q19/00
Inventor 刘强黄辉球黄志刚
Owner 惠州市九惠药业有限公司
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