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Nano magnetic control agglomeration chemotherapeutic pharmaceutical composition and preparation method thereof

A technique for chemotherapeutic drugs and compositions, applied in the field of radiochemotherapy drug compositions and their preparation, can solve the problems of reduced clinical practicability, embolism, low drug adsorption performance, etc.

Inactive Publication Date: 2012-11-14
NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, currently commonly used nanomaterials such as magnetic oxides do not have high adsorption properties for drugs, and are prone to agglomeration in narrow blood vessels to form embolisms, which greatly reduces the clinical practicability of such materials.

Method used

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  • Nano magnetic control agglomeration chemotherapeutic pharmaceutical composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Nano magnetron agglomerated chemotherapeutic drug composition containing I 131 Mg-FeLDH was prepared as follows:

[0025] (1) Weigh ferric nitrate and magnesium nitrate according to the molar ratio of 2:1. After mixing, dissolve them in 100 ml of water to form a mixed solution of ferric nitrate and magnesium nitrate for later use; (2) Take 2.0 grams of NaOH, NaOH 2 CO 3 8.5 g dissolved in 200 ml of water to form NaOH and Na 2 CO 3 The mixed solution, spare;

[0026] (3) Under vigorous stirring, quickly pour the nitrate mixed solution formed in step (1) into the lye formed in step (2), and stir at 80°C for 12 hours; the precipitate is filtered, washed and dried to obtain MgFe (III) Hydrotalcite;

[0027] (4) Take 10 grams of hydrotalcite, ultrasonically disperse it in 200 ml of water, add 100 mg of NaI 131 (Sinopharm Group Shanghai Reagent Company), heat up to 40-120°C, under stirring conditions, ion exchange for 10-20 hours, filter the precipitate, wash, and dry ...

Embodiment 2

[0029] Nano magnetron agglomerated chemotherapeutic drug composition containing I 131 The Zn-FeLDH was prepared as follows:

[0030](1) Mix and dissolve zinc nitrate and ferric nitrate in 100 ml of water at a molar ratio of 1:2, add 200 mg of NaI 131 , stir evenly, set aside;

[0031] (2) Dissolve 3.2 grams of NaOH in 200 ml of water to form a NaOH solution for later use;

[0032] (3) Under vigorous stirring, quickly pour the mixed solution formed in step (1) into the NaOH solution formed in step (2), and age for 20 hours at 60°C under the protection of nitrogen (air isolation), and the product is filtered, After washing and drying, nano hydrotalcite NaI is obtained 131 preparation. The particle size is 30-50nm, the magnetic coercivity Hc value of the sample is 0kA / m, and the specific saturation magnetization б x 4.50A·M 2 / Kg.

Embodiment 3

[0034] Nano magnetron agglomerated chemotherapeutic drug composition containing I 131 The Mg-Fe-AlLDH was prepared as follows:

[0035] (1) Mix ferric nitrate, magnesium nitrate and aluminum nitrate in 100 ml of water according to the molar ratio of 1:1:1;

[0036] (2) Take another 2.0 grams of NaOH, NaOH 2 CO 3 8.5 grams dissolved in 200 ml of water;

[0037] (3) Under vigorous stirring, quickly pour the nitrate mixed solution formed in step (1) into the lye formed in step (2), and stir at 120°C for 10 hours; the precipitate is filtered, washed, and dried to obtain MgAlFe ( III) Hydrotalcite;

[0038] (4) Take 10 grams of the hydrotalcite sample formed in step (3) and ultrasonically disperse it in 200 ml of water, add 100 mg of NaI 131 , Stir at 60-120°C, ion exchange for 10-20 hours, filter the precipitate, wash, and dry to obtain nano-hydrotalcite NaI 131 preparation. The particle size is 40-50nm, the magnetic coercivity Hc value of the sample is 0kA / m, and the spec...

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Abstract

The invention relates to a nano magnetic control agglomeration chemotherapeutic pharmaceutical composition which is characterized in that the molecular formula of the nano magnetic control agglomeration chemotherapeutic pharmaceutical composition is MM'xOH2+3x-n(sigma)A(sigma), wherein x=0.25-4; sigma is within the range from 0 to 0.1 and is larger than 0; M is one or two of divalent metal ions such as Zn<2+>, Mg<2+> and Fe<2+>; M' is one or two of trivalent metal ions such as Al<3+> and Fe<3+>; M and M' can not be iron ion at the same time; the molar ratio of M to M' is 1:4 to 4:1; A is I<125>, I<131> or P<32>; n=1 when A is I<->; n=2 when A is P; and the precursor of P<32> is 32PO4<3->, HP<32>O4<2-> or H2P<32>O4<->. The preparation method of the pharmaceutical composition comprises the steps of: reacting magnetic cations (Fe<2+> and Fe<3+>), radioactive anions (I<125>, I<131> or P<32>) and alkali compound, depositing, and aging to obtain the nano magnetic control agglomeration chemotherapeutic pharmaceutical composition. Under the combined action of the magnetic field and the ultrasonic wave, the composition can be agglomerated along a blood vessel, so that the embolism can not be formed.

Description

technical field [0001] The invention relates to a radiotherapy chemotherapy drug composition and a preparation method thereof, in particular to a nano-medicine preparation capable of magnetic control aggregation. Background technique [0002] Currently, the radiopharmaceutical NaI 131 , NaI 129 , NaH 2 P 32 o 4 / Na 2 HP 32 o 4 , o-iodine 131 Phosphorous iodine hippurate is commonly used in the chemical examination and treatment of thyroid cancer, kidney disease examination and other cancers, and is often used in the form of oral or injection. However, due to the strong side effects of radiopharmaceuticals, drug internal irradiation will kill cancer cells and cause damage to healthy cells due to drug diffusion. [0003] The magnetically controlled agglomeration of nano-medicine can concentrate the drug around the lesion, which can avoid the damage of healthy cells caused by the large-scale diffusion of the drug. Therefore, the research on nanomedicine compounded by ...

Claims

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Application Information

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IPC IPC(8): A61K51/12A61K51/02A61P35/00A61K101/02
Inventor 黄现礼陆扬谢群玲高庆文
Owner NANJING UNIV OF AERONAUTICS & ASTRONAUTICS