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Gel material for preventing intestinal adhesion

A gel material, intestinal adhesion technology, applied in medical preparations containing active ingredients, pharmaceutical science, organic active ingredients, etc., can solve problems such as infection, adverse reactions, reduce isolation effect, and achieve the effect of relieving inflammation

Inactive Publication Date: 2013-11-13
SHANDONG PROVINCIAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the course of clinical use, hyaluronic acid cross-linked preparations have a significant effect on preventing intestinal adhesion, but they will cause serious adverse reactions during use, including abdominal pain, abdominal infection and intestinal adhesion, and some cases even died due to adverse reactions. Reoperation; for example, Intergel is sodium hyaluronate gel, which is marketed in the United States and many European countries, and serious adverse reactions have occurred after the market
At the same time, hyaluronic acid cross-linked preparations will also dissociate in the body during use, thereby reducing its isolation effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Preparation of hydrotalcite colloidal material: 100 parts by weight of AlCl 3 · 6H 2 O with 253 parts by weight MgCl 2 · 6H 2 O was dissolved in 1000 parts of deionized water, and at a stirring speed of 500 rpm, slowly added 655 parts of dilute ammonia water while stirring (dilute ammonia water was an aqueous solution diluted 3 times with 25% concentrated ammonia water), continued to stir for 2 hours, filtered, and the precipitate The product was peptized at 65° C. for 18 hours, and then washed with distilled water to obtain a hydrotalcite colloid material with a volume average particle size of 273 nm.

[0030] (2) Preparation of lubricating solution: take polyacrylamide with a molecular weight of 2,000,000-8,000,000 and the above-mentioned hydrotalcite colloidal material, add water, stir at high speed to form a uniform solution, and obtain a lubricating solution; wherein, the mass percentage of polyacrylamide is 0.01%, hydrotalcite The mass percentage of colloid...

Embodiment 2

[0034] (1) Prepare hydrotalcite colloidal materials with a particle size of 200-300nm by low-saturation co-precipitation method;

[0035] (2) Preparation of lubricating solution: take polyacrylamide with a molecular weight of 2,000,000-8,000,000 and the above-mentioned hydrotalcite colloidal material, add water, stir at high speed to form a uniform solution, and obtain a lubricating solution; wherein, the mass percentage of polyacrylamide is 0.01%, hydrotalcite The mass percentage of colloidal material is 1%;

[0036] (3) Preparation of cross-linked hyaluronic acid gel solution: prepare hyaluronic acid into a hyaluronic acid solution with a mass percentage of 1%, adjust the pH value to 4-5, add a 1.5% FeCl3 solution by mass, the two The volume ratio of the mixture is 10:2. After fully stirring, a cross-linked hyaluronic acid gel solution is obtained;

[0037] (4) Mix the lubricating solution and the cross-linked hyaluronic acid gel at a ratio of 1:2, then add 2-deoxy-D-glucos...

Embodiment 3

[0039] (1) Prepare hydrotalcite colloidal materials with a particle size of 200-300nm by hydrothermal synthesis;

[0040] (2) Preparation of lubricating solution: take polyacrylamide with a molecular weight of 2,000,000-8,000,000 and the above-mentioned hydrotalcite colloidal material, add water, stir at high speed to form a uniform solution, and obtain a lubricating solution; wherein, the mass percentage of polyacrylamide is 0.01%, hydrotalcite The mass percentage of colloidal material is 1%;

[0041] (3) Preparation of cross-linked hyaluronic acid gel solution: prepare hyaluronic acid into a hyaluronic acid solution with a mass percentage of 1%, adjust the pH value to 4-5, add a 1.5% FeCl3 solution by mass, the two The volume ratio of the mixture is 10:2. After fully stirring, a cross-linked hyaluronic acid gel solution is obtained;

[0042] (4) Mix the lubricating solution and the cross-linked hyaluronic acid gel at a ratio of 1:3, then add 2-deoxy-D-glucose (2-DG), tramad...

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Abstract

The invention relates to a gel material for preventing intestinal adhesion, which is used for preventing peritoneal adhesion after operation. Hyaluronic acid crosslinking preparations for isolating damaged wounds can cause severe adverse reactions during application, such as abdominal pain, abdominal infection, and intestinal adhesion, and even reoperation is performed due to adverse reactions for some patients; the hyaluronic acid crosslinking preparations also have a dissociation phenomenon in the body, and the isolation effect is reduced. The gel material for preventing intestinal adhesion of the invention is a gel system formed by polyacrylamide, a hydrotalcite colloid material, iron ion crosslinked hyaluronic acid gel liquid, 2-deoxy-D-glucose (2-DG) with anti-inflammation and pain-relieving efficacy, tramadol hydrochloride, and acetaminophen. After operation, the gel material is coated directly on a wound; crosslinking effect is generated with fibrin blood clots on the wound; thus the gel material is firmly adhered to the wound; good isolation effect is reached. The medicinal components with anti-inflammation pain-relieving efficacy are directly applied to the wound; and inflammation caused by singly application of hyaluronic acid isolating substances is alleviated.

Description

technical field [0001] The invention relates to a material for preventing peritoneal adhesion after operation, in particular to a gel material for preventing intestinal adhesion. Background technique [0002] Intestinal adhesions are a common complication of abdominal and pelvic surgery. According to literature, the incidence of intestinal adhesions is 67-93% in abdominal surgery, and as high as 97% in gynecological pelvic surgery. Complications caused by abdominal and intestinal adhesions include intestinal obstruction, difficult reoperation, chronic abdominal and pelvic pain, etc. About half of intestinal obstructions are caused by intestinal adhesions. Current preventive measures for intestinal adhesions include: reducing intraoperative trauma, reducing inflammatory responses, inhibiting agglutination, promoting fibrinolysis, and isolating damaged tissue surfaces that may cause adhesions. From the perspective of clinical therapeutics, preventive measures are divided int...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/04A61L31/14A61L31/16A61K31/7004A61K9/06A61P41/00A61K31/137A61K31/167
Inventor 郭晓波
Owner SHANDONG PROVINCIAL HOSPITAL
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