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Method for extracting persimmon leaf tartaric acid by combining microwave-assisted extraction and membrane separation

A membrane separation and microwave technology, which is used in pharmaceutical formulations, cosmetic preparations, preparations for skin care, etc., can solve the problems of large impurity content, unstable quality, long extraction time, etc., and achieve high yield and short extraction time. , the effect of significant economic benefits

Inactive Publication Date: 2013-01-02
NANNING JIAOYANG PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional methods for extracting persimmon leaf fruit acid are generally solvent extraction methods, such as ethanol reflux extraction method, ether cold immersion extraction method, etc. These methods are simple and easy, but the extraction time is long, the yield is not high, and the impurity content is relatively large , the quality is also unstable, and it is difficult to meet the requirements as a cosmetic raw material

Method used

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  • Method for extracting persimmon leaf tartaric acid by combining microwave-assisted extraction and membrane separation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Specific steps are as follows:

[0031] (1) After crushing the naturally dried persimmon leaves, add 8 times the weight of 55% ethanol to soak for 1 hour, extract in a microwave environment for 10 minutes, and keep the temperature of the persimmon leaves and the solution at 65°C;

[0032] (2) The above liquid is introduced into the operating system equipped with a filter membrane, and the filter operation is performed at a pressure of 0.3 MPa and a temperature of 60°C to remove impurities such as chlorophyll, polysaccharides, and tannins, and when concentrated to one-third of the original liquid For a while, add dialysis water to elute the organic acid;

[0033] (3) adopt low-temperature vacuum distillation to remove moisture, and concentrate the obtained organic acid aqueous solution until reaching one-fifth of the original volume, stop the distillation, and collect the concentrated solution;

[0034] (4) With 4% sodium hydroxide solution, adjust the pH value to 8, ca...

Embodiment 2

[0037] Specific steps are as follows:

[0038] (1) After crushing the naturally dried persimmon leaves, add 8 times the weight of 75% ethanol to soak for 1.5 hours, then extract in a microwave environment for 15 minutes, and keep the temperature of the persimmon leaves and the solution at 70°C;

[0039] (2) The above liquid is introduced into the operating system equipped with a filter membrane, and the filter operation is carried out at a pressure of 0.4 MPa and a temperature of 70°C to remove impurities such as chlorophyll, polysaccharides, tannins, etc., when concentrated to one-third of the original liquid For a while, add dialysis water to elute the organic acid;

[0040] (3) adopt low-temperature vacuum distillation to remove moisture, and concentrate the obtained organic acid aqueous solution until reaching one-fifth of the original volume, stop the distillation, and collect the concentrated solution;

[0041] (4) With 5% sodium hydroxide solution, adjust the pH value ...

Embodiment 3

[0044] Specific steps are as follows:

[0045] (1) After crushing the naturally dried persimmon leaves, add 8 times the weight of 100% ethanol to soak for 2 hours, then extract in a microwave environment for 20 minutes, and keep the temperature of the persimmon leaves and the solution at 75°C;

[0046] (2) Introduce the above-mentioned liquid into an operating system equipped with a filter membrane, and perform a filtration operation at a pressure of 0.5 MPa and a temperature of 80°C to remove impurities such as chlorophyll, polysaccharides, and tannins, and when concentrated to one-third of the original liquid For a while, add dialysis water to elute the organic acid;

[0047] (3) adopt low-temperature vacuum distillation to remove moisture, and concentrate the obtained organic acid aqueous solution until reaching one-fifth of the original volume, stop the distillation, and collect the concentrated solution;

[0048] (4) With 6% sodium hydroxide solution, adjust the pH value...

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Abstract

The invention relates to a method for extracting persimmon leaf tartaric acid which is an active ingredient in a persimmon leaf by the coupling technique of microwave-assisted extraction and membrane separation. The method comprises the following steps of: after the dried persimmon leaf is smashed, adding ethanol, and extracting at constant pressure and under the microwave environment; removing organic acid substances, such as chlorophyll, tannin, resin, reducing sugar and polysaccharide by the membrane separation technology; after the mixture is condensed, successively adding alkali and acid to process; and finally recrystallizing to obtain the persimmon leaf tartaric acid. The raw material adopted by the method disclosed by the invention is the natural persimmon leaf, no three wastes are generated, and the technology is simple and environment friendly. The method has the advantages of short extraction time, high yield, small impurity content and stable quality, and the obtained product persimmon leaf tartaric acid achieves the requirement for serving as the raw material of cosmetics, and the economic benefit is obvious.

Description

technical field [0001] The invention belongs to the field of natural products, and in particular relates to a method for extracting persimmon leaf fruit acid, an active ingredient in persimmon leaves, by using microwave extraction and membrane separation combined technology. technical background [0002] The main chemical components of persimmon leaves are flavonoid glycosides, tannins, phenols, resins, coumarins, reducing sugars, polysaccharides, volatile oils, organic acids, chlorophyll, etc. Persimmon leaf acid is a mixture of various organic acids extracted from persimmon leaves, including active substances such as ursolic acid and oleanolic acid. Ursolic acid is a triterpenoid compound that has various biological effects such as sedative, anti-inflammatory, antibacterial, anti-diabetic, anti-ulcer, and hypoglycemic. At the same time, ursolic acid also has obvious antioxidant function, so it is widely used as a raw material for medicine and cosmetics. Oleanolic acid is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K8/63A61Q19/02
Inventor 王立升梁勇刘旭
Owner NANNING JIAOYANG PHARM
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