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Method for preparing pericarpium granati polyphenol gel for treating gynecological inflammation

A phenol gel, gynecological inflammation technology, applied in the field of vaginitis or cervicitis gel in gynecological inflammation, can solve the problems of easy to damage the vagina, difficult to penetrate deep into the vagina, easy to flow out of the vagina, etc., to increase comfort and adaptability, fine and uniform texture, enhanced efficacy

Active Publication Date: 2013-01-09
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The douching solution has a short action time and is not easy to penetrate deep into the vagina; the tablet is inconvenient to use, which may easily cause a foreign body sensation in the vagina and easily damage the vagina; the suppository dissolves and becomes a liquid that easily flows out of the vagina and contaminates the clothes. Full release; the vaginal film is made of a polymer film as a carrier and inserted into the vagina. Although it is convenient to prepare and use, the contact surface between the drug and the mucous membrane is small

Method used

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  • Method for preparing pericarpium granati polyphenol gel for treating gynecological inflammation
  • Method for preparing pericarpium granati polyphenol gel for treating gynecological inflammation
  • Method for preparing pericarpium granati polyphenol gel for treating gynecological inflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Preparation of pomegranate peel polyphenol extract:

[0019] Take the pomegranate peel and crush it into a coarse powder, add 5 times the concentration of 35% ethanol and warm soak, the temperature is 71°C, extract once for 3 hours, filter, the filtrate is decompressed to recover ethanol, and concentrate to contain 0.15g of pomegranate peel per mL the concentrate;

[0020] Add the concentrated solution to the treated HPD600 macroporous adsorption resin column, absorb for 6 hours, first elute with deionized water until the color of the effluent is light, and then elute with 2 times the column volume of 50% ethanol , collect the alcohol-containing eluent, reclaim ethanol, concentrate under reduced pressure and vacuum-dry to form an extract, pulverize, and pass through an 80-mesh sieve to obtain a pomegranate peel polyphenol extract for subsequent use, wherein the total polyphenol content of the extract is 62%. The content of flower acid is 3.6%, the content of punicalagi...

Embodiment 2

[0024] Preparation of pomegranate peel polyphenol extract:

[0025] Take the pomegranate peel and crush it into a coarse powder, add 8 times the concentration of 49% ethanol to warm soak, the temperature is 75 ° C, extract twice, each time for 2 hours, filter, combine the filtrate to recover ethanol under reduced pressure, concentrate to contain pomegranate peel per mL 0.18g of concentrate;

[0026] Add the concentrated solution to the treated HPD600 macroporous adsorption resin chromatographic column, adsorb for 8 hours, first elute with deionized water until the effluent is nearly colorless, and then elute with 60% ethanol at a concentration of 3 times the column volume. Collect the alcohol-containing eluent, reclaim ethanol, concentrate under reduced pressure and vacuum-dry to form an extract, pulverize, pass through a 100-mesh sieve, and obtain a pomegranate peel polyphenol extract for subsequent use, wherein the total polyphenol content in the pomegranate peel polyphenol ...

Embodiment 3

[0030] Preparation of pomegranate peel polyphenol extract:

[0031] Take the pomegranate peel and crush it into a coarse powder, add 15 times the concentration of 40% ethanol and warm soak, the temperature is 80 ℃, extract 3 times, each time for 1.5 hours, filter, combine the filtrate to recover ethanol under reduced pressure, concentrate to contain pomegranate peel per mL 0.2 g of concentrate;

[0032] Add the concentrated solution to the treated HPD600 macroporous adsorption resin chromatographic column, absorb for 12 hours, first elute with distilled water until the effluent is nearly colorless, then elute with 60% ethanol at a concentration of 4 times the column volume, collect the The ethanol eluate is recovered from the ethanol, concentrated under reduced pressure and vacuum-dried to form an extract, crushed, and passed through a 120-mesh sieve to obtain a pomegranate peel polyphenol extract for later use, wherein the total polyphenol content in the pomegranate peel poly...

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Abstract

The invention relates to a method for preparing a pericarpium granati polyphenol gel for treating gynecological inflammation. The gel is obtained by taking a pericarpium granati polyphenol extract as raw material, and adding adjuvants such as pharmaceutically acceptable gel matrix material including Carbomer or hydroxypropyl methylcellulose or sodium carboxymethylcellulose, propylene glycol or glycerol and propylene glycol as humectant, Tween as solubilizer, methylparaben or ethylparaben as preservative, and triethanolamine as pH regulator. The pericarpium granati polyphenol gel is obtained by preparing the pericarpium granati polyphenol extract, dissolving the pericarpium granati polyphenol extract with the humectant or / and the solubilizer and then adding into the dispersed gel matrix for uniformly dispersing, adding the preservative and the balance of water, uniformly mixing, and regulating the pH value to 4.0 to 5.0. The gel obtained by the method is utilized to prevent and treat gynecological inflammation caused by the bacteria, such as vaginitis or cervicitis, and has the characteristics of being convenient to administrate, good in absorption and high in efficacy.

Description

technical field [0001] The present invention relates to a method for preparing pomegranate peel polyphenol gel for treating gynecological inflammation, in particular to a gel prepared with pomegranate peel polyphenol as raw material for vaginitis or cervicitis in gynecological inflammation caused by bacteria Gel. Background technique [0002] Vaginitis, cervicitis and other gynecological inflammations seriously threaten women's health. Due to the particularity of female reproductive organs, gynecological inflammation has become a common and frequently-occurring disease in adult women. Its clinical manifestations are diverse, the etiology is complex, and it is often accompanied by a variety of serious complications, which has a great impact on women's life and work. Vaginitis is a general term for various vaginal mucosal diseases caused by different etiologies. In a normal physiological state, due to the characteristics of anatomical tissues, the vagina has a natural defens...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/06A61P15/00A61P15/02A61P31/04A61K129/00
CPCA61K9/0034A61K9/06A61K47/38A61K36/185A61P15/00A61P15/02A61P31/04
Inventor 阿吉艾克拜尔·艾萨罗玉琴热比姑丽·伊斯拉木热依木古丽·阿布都拉来海中
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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