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Novel application of naringin

A technology of naringin and naringin, applied in the field of medicine, can solve problems such as memory impairment

Inactive Publication Date: 2013-01-16
INST OF LAB ANIMAL SCI CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Brain glucose metabolism disorders and / or long-term memory impairment exist in many brain tissue diseases. Although there are many reports on the effects of naringin on nerve tissues, there is no research on its effects on brain tissue glucose metabolism and synaptic plasticity. to report

Method used

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  • Novel application of naringin
  • Novel application of naringin
  • Novel application of naringin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Naringin improves APPswe / PS1dE9 transgenic mice and long-term memory ability

[0018] APPswe / PS1dE9 transgenic mice were randomly divided into 12 groups, half male and half female, and 12 wild mice were selected as the control group. These mice were matched in sex and weight, and the transgenic mice were divided into 4 groups: AD placebo group, Aricept treatment group (2mg / kg / d), naringin treatment group (50mg / kg / d), naringin treatment group (100mg / kg / d). The mice in the placebo group and the control group were given conventional standard mouse food. The Aricept treatment group and the naringin treatment group added corresponding doses of drugs to the conventional standard mouse food. The daily intake of mouse food was calculated as follows : Each mouse with a body weight of 20g, daily ingestion of 3g of mouse food, selected 3-month-old mice for administration, and the treatment time was 16 weeks, and behavioral experiments were carried out after administrati...

Embodiment 2

[0021] Example 2: Naringin increases glucose uptake and transport in the brain tissue of APPswe / PS1dE9 transgenic mice

[0022] Positron Emission Tomography (PET) is an important tool for in vivo diagnosis of brain diseases by using radioactive markers for in vivo molecular imaging to analyze brain glucose metabolism and indirectly reflect neuron activity. In this study, PET technology was used in the experimental study of transgenic mice to non-invasively and quantitatively measure the utilization of glucose in different brain regions. The results showed that compared with wild control mice, APPswe / PS 1dE9 transgenic mice brain tissue decreased glucose uptake by 38%, temporal lobe by 44%, and hippocampus by 41%; compared with APPswe / PS1dE9 transgenic mice , naringin treatment group (100mg / kg / d) mice increased frontal lobe glucose uptake by 72.5%, temporal lobe by 61%, and hippocampus by 62% (see image 3 ), and found for the first time that naringin can increase the utilizat...

Embodiment 3

[0023] Example 3: Naringin activates calcium / calmodulin-dependent protein kinase and downstream AMPA glutamate receptors

[0024] Long term potentiation (LTP) is the material basis of learning and memory, and CaMK Ⅱ is involved in the induction and maintenance of LTP, and plays a key role in the formation and maintenance of learning and memory. Activated CaMK Ⅱ can further activate the activity of AMPA (Ser83l) in the downstream brain tissue, thereby activating AMPA receptors and increasing intracellular Ca 2+ concentration, induce excitatory postsynaptic current enhancement, and promote excitatory transmission of glutamatergic neurons. At the same time, phosphorylated AMPA receptors can also insert AMPA receptor-binding proteins into the post-synaptic dense components, anchor the newly added AMPA, turn silent synapses into effective synapses, and improve synaptic transmission efficiency. In this study, it was observed by immunoblotting that the phosphorylation level of CaMK ...

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Abstract

The invention belongs to the field of medicines, discloses an application of naringin in preparing drugs for improving brain tissue glucose hypometabolism and long-term hypomnesis. What firstly found is that the naringin can increase glucose uptake and transport of the brain tissues, improve energy metabolism disturbance, simultaneously activate calcium / calmodulin dependence protein kinase and downstream AMPA glutamate receptors, promote excitability transmission of glutamatergic neurons and improve long-term memory, thereby improving symptoms of neurodegenerative diseases and delaying disease's progression. The naringin has the potentiality for developing into drugs or health preparations for treating brain tissue diseases which are characterized by brain glycometabolism disturbance and / or long-term memory impairment.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of naringin in the preparation of medicines and health preparations for improving hypoglycemia and long-term memory in brain tissue. Background technique [0002] In recent years, several parallel epidemiological, neuropathological, and functional imaging studies from different clinical and experimental models have shown that brain hypoglycemia and energy disturbances precede the occurrence of neurocognitive impairment and behavioral abnormalities. Positron emission tomography (Position Emission Tomography, PET) shows that the glucose metabolism rate of the cerebral cortex has been abnormal before cognitive decline and corresponding parts of CT and MRI have no abnormal changes in patients with Alzheimer's disease. The degree of decline was positively correlated with the severity of cognitive impairment. Consistent with this result, persistent, progressive, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P25/28
Inventor 张连峰王冬梅杨亚军张丽曹兴水
Owner INST OF LAB ANIMAL SCI CHINESE ACAD OF MEDICAL SCI
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