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Extraction method using microbubbles and extracting liquid

A technology of ultra-fine bubbles and extraction methods, applied in the field of extracts, can solve problems such as solvent or additive residues, safety concerns, and residual irritating odors, and achieve excellent results in terms of safety

Inactive Publication Date: 2013-01-16
莱格瑞克株式会社 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, these extraction methods have many problems in terms of potency and quality, etc.
For example, in the existing steam distillation method, it is necessary to extract by heating or distilled solvent, so there are cases where the obtained components deteriorate, the solvent remains, and a pungent odor remains.
In addition, in terms of production, a relatively large amount of solvent is required, and solvent removal, etc. must be performed.
Furthermore, the hydrophilic components cannot be extracted
[0005] In addition, in the extraction method using water, the extraction amount of components is low and the components that can be extracted are limited. Therefore, an extraction method using a mixture with a hydrophilic solvent (Patent Document 1) and a method of adding a small amount of emulsifier ( Patent Document 2), however, there are cases where solvents or additives remain to a certain extent, and there are restrictions on the use of the extract and concerns about safety
In addition, a method of obtaining an extract by supercritical extraction in which carbon dioxide gas is brought into a supercritical state has also been proposed (Patent Document 3), but there are problems of cost, equipment, etc.

Method used

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  • Extraction method using microbubbles and extracting liquid
  • Extraction method using microbubbles and extracting liquid
  • Extraction method using microbubbles and extracting liquid

Examples

Experimental program
Comparison scheme
Effect test

manufacture example 1）

[0108] Using a gas-liquid mixing and shearing ultrafine bubble generating device (BAVITAS, manufactured by Kyowa Equipment Co., Ltd.), ultrafine bubbles containing air are generated in ion-exchanged water to prepare water containing ultrafine bubbles. The maximum frequency particle size of the ultrafine bubbles in this water was 100 nm, the total number of particles with an existing number of 500 nm or less was 0.8×108 / mL, and the Zeta potential was −20 mV. In addition, the zeta potential was measured with a zeta potential measurement system ELSZ-1 manufactured by Otsuka Electronics Co., Ltd.

Embodiment 1）

[0110] The seeds of neem (Nature neem company) were pulverized with a mixer, and 20 mL of ion-exchanged water containing ultrafine bubbles obtained in Production Example 1 was added to 1 g of the obtained pulverized product to prepare a mixture. The mixture was extracted by irradiating ultrasonic waves (40 kHz) at 21° C. for 15 minutes with an ultrasonic device (USCLEANER model USD-4R, manufactured by AS-1 Co., Ltd.). Thereafter, the residue was removed by filtration through filter paper to obtain a filtrate (called an extract). The obtained extract was measured for the amounts of azadirachtin A and B, azadirachtin and salannin contained in the extract using high-speed liquid chromatography (Lachrom Elite, manufactured by Hitachi High-Technologies). The measurement results are shown in Table 1.

[0111] In addition, the measurement conditions are: water is used as solvent A, acetonitrile is used as solvent B, solvent B is 30-40% in 0-10 minutes, solvent B is 40-50% in 10-15 m...

Embodiment 2）

[0113] Instead of ultrasonic irradiation, stirring (number of rotations: 100 rpm) by a stirring device (manufactured by Shaker SA300 Yamato) for 60 minutes, and the extraction temperature was room temperature (18 to 25° C.), and the extraction treatment was carried out in the same manner as in Example 1, Determination of filtration and filtrate (extract). The measurement results are shown in Table 1.

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Abstract

Disclosed is a safe extracting method that does not use, or reduces an amount of an emulsifier or organic solvent and the like that is used, and efficiently extracts components from various extractable materials. When a component to be extracted is an active ingredient, the method maintains a high titer thereof. The extracting method extracts extractable material by contacting with water that contains microbubbles. With the extraction method, microbubble model-particle diameters of 500 nm or lower are preferred. Another preferred example is the existence of 1 million or more microbubbles per 1 mL of water.

Description

technical field [0001] The present invention relates to an extraction method using ultrafine bubbles and an extraction liquid obtained by the extraction method. Background technique [0002] Conventionally, in order to extract a desired component from an extract, aqueous solvents, organic solvents, etc. are generally used, and soluble components are extracted in each solvent to obtain an extract (extract). [0003] As the extract, for example, plant raw materials are used. When obtaining the extract, water, methanol, ethanol, butanol, isopropanol, hexane, heptane, cyclohexane, ethyl acetate, acetone, petroleum Organic solvents such as ether, polyols such as 1,3-butanediol, glycerin, and propylene glycol, oils such as castor oil, olive oil, sunflower oil, squalane, liquid paraffin, or mineral oils alone or appropriately Mixed and used as an extraction solvent, the soluble components are extracted from the plant as it is or dried plant by direct or processing such as pulveriz...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D11/02B01F1/00B01F3/04
CPCB01D11/0265B01D11/0211A61P25/20A61P35/00A61P3/08A61P35/04A61P37/08Y02P20/54
Inventor 辻秀泰辻康广冈彻宫尾悠D·廖夫
Owner 莱格瑞克株式会社