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Hygroscopic humectant capable of replacing hyaluronic acid

A technology of hyaluronic acid and moisturizing agent, which can be used in skin care preparations, dough treatment, medical preparations with inactive ingredients, etc., can solve the problems of complex preparation process, unsatisfactory moisturizing effect and high cost, and achieve biological phase The effect of good capacitance, outstanding commercial value and cost reduction

Active Publication Date: 2013-01-23
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Chinese patent CN 200910010837.3, beauty and skin care moisturizing agent, made of dimethyl amino acid proline, glycerin, shea butter, honey, etc., is not only expensive, but can only be used in skin care cosmetics
Chinese patent CN 98110568, the preparation of chitosan derivative cosmetic moisturizer, using chitosan as the matrix, prepared chitosan acylate (succinyl chitosan sodium, maleoyl chitosan sodium) and chitosan Sugar hydroxyalkylated derivatives (ethylene glycol chitosan and glycerol chitosan), and the development of these four chitosan derivatives into cosmetic moisturizers as hyaluronic acid replacement or replacement products, preparation process Complex, acid-base pollution, poor moisturizing effect
The present invention obtains carboxymethyl hyaluronic acid through an effective synthesis method, but the process flow of the patented method is long, polluting and high in cost
[0006] Chinese patent ZL200410024504.3 introduces the preparation method of laminin (salt) and the research on its use as antihypertensive drug and blood lipid lowering drug, but there is no record of its use as a hygroscopic and moisturizing agent

Method used

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  • Hygroscopic humectant capable of replacing hyaluronic acid
  • Hygroscopic humectant capable of replacing hyaluronic acid
  • Hygroscopic humectant capable of replacing hyaluronic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The mass fraction of laminin and / or lamininate is 100 parts, and other auxiliary agents are 0 parts. Use it as a moisture-absorbing humectant in lotions. The moisture-absorbing moisturizing agent is added in an amount of 0.25% in the lotion, and the measured relative moisturizing rate is 108% in parts by weight. Under the same moisturizing rate, the cost of using this hygroscopic moisturizing agent in lotion is only 30% of that of hyaluronic acid.

Embodiment 2

[0026] 17 parts by mass of laminacin and / or laminacin salt, 1 part by mass of hyaluronic acid, 5 parts by mass of sodium pyrrolidone carboxylate, 1 part by mass of glycerin, 1 part by mass of propylene glycol, 1 part by mass , 2 parts by mass of 3-butanediol, 1 part by mass of ethylene glycol, 2 parts by mass of ethanol, and 70 parts by mass of water. Use it as a moisture-absorbing humectant in lotions. The moisture-absorbing moisturizing agent is added in an amount of 2% in the lotion, and the measured relative moisturizing rate is 112% in parts by weight. Under the same moisturizing rate, the cost of using this hygroscopic moisturizing agent in lotion is only 25% of that of hyaluronic acid.

Embodiment 3

[0028] 15 parts by mass of laminacin and / or laminacin salt, 7 parts by mass of sodium pyrrolidone carboxylate, 3 parts by mass of glycerin, and 75 parts by mass of water. Use it as a hygroscopic moisturizer in body creams. The moisture-absorbing moisturizing agent is added in an amount of 2% in the moisturizer, and the measured relative moisturizing rate is 107% in parts by weight. Under the same moisturizing rate, the cost of using this moisturizer in moisturizer is only 20% of that of hyaluronic acid.

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Abstract

The invention discloses a hygroscopic humectant capable of replacing hyaluronic acid. In the hygroscopic humectants, laminine and / or laminine salt is used as a main agent, and other assistants are used as auxiliary agents; and the other assistants are one or more selected from hyaluronic acid, pyrrolidone sodium carboxylate, glycerol, propylene glycol, glycol, ethanol and water. In the invention, the expensive hyaluronic acid is replaced by the relatively cheap laminine and / or laminine salt as the hygroscopic humectants, so that the cost is significantly reduced; and according to data statistics, the cost of using laminine and / or laminine salt is only 1 / 10 to 1 / 5 of the cost of the hyaluronic acid, so that the commercial value of the hygroscopic humectants is very significant.

Description

technical field [0001] The invention relates to a hygroscopic and moisturizing agent used in the daily chemical field and the pharmaceutical industry, in particular to a non-protein amino acid hygroscopic and moisturizing agent which can replace hyaluronic acid. Background technique [0002] Moisturizing agent is a commonly used quality maintenance agent in medicine, cosmetics, food, tobacco and other industries, and can also be used for comfort treatment of textiles. [0003] Hyaluronic acid (Hyaluronic acid, HA for short), also known as hyaluronic acid, is an acidic polymucopolysaccharide, a white amorphous solid, odorless and tasteless, soluble in water and insoluble in organic solvents. HA has strong water absorption and is currently the best moisturizing substance found in nature. Its water absorption value is as high as 500ml / g, which is better than glycerin, propylene glycol, sorbitol, polyethylene glycol, lactic acid, sodium pyrrolidone carboxylate, etc. Moisturizin...

Claims

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Application Information

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IPC IPC(8): A61K8/44A61K47/18D01F1/10A24B15/32A21D2/24A23L1/03C07C229/26A61Q19/00A23L29/00
Inventor 李群李子超赵昔慧孔合心
Owner QINGDAO UNIV
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