Method for preparing C20 position dehydroxylation dammarane type rare ginsenoside and aglycone thereof

A dehydration reaction and compound technology, applied in the field of natural medicines, can solve the problems of difficult separation, poor purity, high extraction cost, etc., and achieve the effect of low preparation cost and simple reaction steps
CN102911238BActive Publication Date: 2014-11-26CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2014-11-26

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Abstract

The invention relates to the field of natural medicine, in particular to a method for preparing C20 position dehydroxylation dammarane type rare ginsenoside and aglycone thereof. The method for preparing the C20 position dehydroxylation dammarane type rare ginsenoside and the aglycone thereof is achieved by combining multiple means of semi-synthesis preparation, chromatogram separation and purification and the like. The method is characterized in that ginsenoside Rg2, Rh1, Rg3, Rs3 and Rh2, protopanoxadiol and protopanaxatriol are used as raw materials, one-step dehydration reaction is performed under the acidic condition, C20 position hydroxyl is removed to generate double bond isomerous series C20 position dehydroxylation dammarane type rare ginsenoside and the aglycone thereof, a liquid phase is prepared to enrich a target compound, and the target compound is concentrated and freeze-dried to obtain the C20 position dehydroxylation dammarane type rare ginsenoside and the aglycone thereof. According to the method, raw materials are easy to obtain, the reaction steps are simple, and the preparation cost is low.
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Description

technical field

[0001] The present invention relates to the field of natural medicines, in particular to a C 20 A method for preparing rare ginsenosides and aglycones of the dehydroxylated dammarane type, that is, combining semi-synthetic preparation, chromatographic separation and purification to obtain C 20 A method for the dehydroxylation of dammarane-type rare ginsenosides and their aglycones. Background technique

[0002] Ginseng plants (ginseng, American ginseng, notoginseng, etc.) have a long history and definite curative effects, and have become one of the most popular and widely used Chinese herbal medicines in the world. Modern pharmacological studies have shown that its main active ingredient, ginsenoside, has multiple effects such as anti-inflammatory, anti-oxidant, neuroprotective, and improved cardiovascular blood supply (L.P.Christensen, AdvFoodNutrRes, 2008, 55, 1; W.D.Rausch et al., Acta Neurobiol Exp, 2006 , 66, 369; A.A. Pawar. et al., Phytother Res, 200...

Claims

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