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Mesona chinensis benth polysaccharide and preparation method and applications thereof

A technology of jelly jelly and polysaccharide, applied in jelly jelly polysaccharide and its preparation and application field, can solve the problems of low anti-radiation biological activity and low molecular weight of jelly jelly polysaccharide, so as to improve survival rate, reduce hematopoietic system and immune organs damage, and the effect of improving the purification rate

Inactive Publication Date: 2013-02-13
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] One of the objectives of the present invention is to provide a kind of polysaccharide with weak alkali solution extraction and alcohol precipitation method to solve the technical problems of low molecular weight and low anti-radiation biological activity of the above-mentioned water extraction and alcohol precipitation method. jelly jelly polysaccharide with high molecular weight and excellent anti-radiation biological activity, and the preparation method has high purification yield and less ethanol consumption

Method used

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  • Mesona chinensis benth polysaccharide and preparation method and applications thereof
  • Mesona chinensis benth polysaccharide and preparation method and applications thereof
  • Mesona chinensis benth polysaccharide and preparation method and applications thereof

Examples

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Embodiment 1

[0037] A kind of jelly jelly polysaccharide, its preparation process comprises the steps:

[0038] (1) Dry and pulverize the whole jelly grass, and control the pulverization particle size to 50-100 mesh;

[0039] In a water bath, mix 9g of jellygrass whole herb powder and 250mL of 1.5% sodium carbonate aqueous solution, control the temperature at 95°C and extract for 1.5h, and filter the obtained extract with medical gauze and two layers of gauze to make jelly jelly The slag is filtered clean;

[0040] (2), decolorize the filtrate obtained in step (1) with 20mL of 10% hydrogen peroxide per 100mL, and control the temperature at 50°C during the decolorization process;

[0041] (3), step (2) After the decolorization is completed, use a 10K hollow fiber membrane tube for ultrafiltration purification;

[0042] (4), the filtrate obtained after ultrafiltration and purification in step (3) was added to anhydrous ethanol with a volume of 70% of the feed liquid, and then the temperatu...

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Abstract

The invention discloses a method for preparing mesona chinensis benth polysaccharide. The method comprises the following steps that mesona chinensis benth herb is dried and crushed to obtain mesona chinensis benth herb powder, and the mesona chinensis benth herb powder is mixed with 1.0-2.0 percent of sodium carbonate water solution, and then the mixture is extracted at the temperature of 93-97 DEG C for 1.3-1.7 hours and then is filtered; the obtained filtrate is decolored with 10 percent of hydrogen peroxide at the temperature of 45-55 DEG C, and the decolored filtrate is ultrafiltered and purified by 10 K hollow fiber membrane tubes; and the ultrafiltered and purified filtrate is added into absolute ethyl alcohol with 70 percent of filtrate volume, then is centrifuged at the temperature of 4 DEG C and the rotating speed of 5,000rpm after 2-8 hours, sediment is collected and is subjected to freeze drying, and finally the mesona chinensis benth polysaccharide is obtained. The mesona chinensis benth polysaccharide obtained by the method has a radiation-proof effect.

Description

technical field [0001] The invention relates to jelly jelly polysaccharide, its preparation method and its application in anti-radiation activity. Background technique [0002] In my country, jelly jelly has a long history as a Chinese herbal medicine and as a raw material for making jelly jelly. At present, most of the research on Jelicia jelly is limited to the whole plant, but the research on the specific components in jelly jelly, especially the polysaccharides of jelly jelly, is limited. At present, the reports on extracting the whole plant jelly jelly polysaccharide mainly use water extraction and alcohol precipitation method. The yield is 20%, and the amount of ethanol is about 2.33 times the volume of the extract, so the yield of jelly jelly whole herb polysaccharide prepared by this method is not high, and the amount of ethanol required is relatively large, and the purification efficiency is 5h / g. The yield is 20%, the molecular weight of the whole herb polysacchar...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/715A61P39/00
Inventor 冯涛庄海宁王旭
Owner SHANGHAI INST OF TECH
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