High immunogenicity rabies virus glycoprotein, its preparation method and application

A technology of rabies virus and high immunity, which is applied in the field of 0., the preparation of highly immunogenic rabies virus glycoprotein, and the field of highly immunogenic rabies virus glycoprotein, to reduce production costs, avoid vaccine failure, and improve immunogenicity Effect
CN102964433AInactive Publication Date: 2013-03-13MILITARY VETERINARY RES INST PLA MILITARY MEDICAL ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
MILITARY VETERINARY RES INST PLA MILITARY MEDICAL ACAD OF SCI
Publication Date
2013-03-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a high immunogenicity rabies virus glycoprotein and its preparation method as well as application. The preparation method consists of: performing artificial synthesis to acquire an all dominant neutralization epitope-containing and codon optimized rabies virus glycoprotein gene, then taking a recombinant adenovirus, a recombinant baculovirus or a slow virus as an expression vector, and performing high-efficiency expression in a mammalian cell line, an insect cell line or a silkworm expression system, thus obtaining the rabies virus glycoprotein that has high immunogenicity to domestic epidemic rabies virus strains currently. And the high immunogenicity rabies virus glycoprotein is used for immunoprophylaxis of animal rabies.
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Description

Technical field:

[0001] The invention relates to a highly immunogenic rabies virus glycoprotein, in particular provides a preparation method and application of a highly immunogenic rabies virus glycoprotein, and belongs to the technical field of genetic engineering vaccines. Background technique:

[0002] Rabies is a zoonotic disease with almost 100% fatality rate. my country is an area with a high incidence of rabies, and human rabies is mainly caused by biting or scratching (exposure) by dogs or cats carrying rabies virus. There are many rabies virus strains prevalent in my country. Although they all belong to genotype 1 and have cross protection among each other, the strains used in the current rabies vaccine are all foreign strains (PV, PM, SAD) and early Chinese epidemic strains (CTN, aG), Decades of evolution have resulted in distinct differences in glycoprotein genes. Studies have shown that the glycoproteins of different rabies virus strains have different immunog...

Claims

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