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Iron ferric oxide nanoparticles with ct/mri dual function and its preparation method and application

A technology of ferroferric oxide and nanoparticles, which is applied in the field of materials, can solve the problems of complex preparation process, unsuitability for expanding production, high cost, etc., and achieve the effect of simple preparation device, low price and simple operation

Active Publication Date: 2014-10-29
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation of CT / MRI dual-functional nanoparticles needs to modify materials with CT contrast function on the surface of magnetic nanoparticles, such as modified gold nanoparticles, but the preparation process is complicated and the cost is high, so it is not suitable for expanding production.

Method used

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  • Iron ferric oxide nanoparticles with ct/mri dual function and its preparation method and application
  • Iron ferric oxide nanoparticles with ct/mri dual function and its preparation method and application
  • Iron ferric oxide nanoparticles with ct/mri dual function and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 prepares 2,3,5-triiodobenzoyl chloride

[0027]Take 2 mmol (1 g) of 2,3,5-triiodobenzoic acid in a 100 ml single-necked flask, quickly add 30 ml of thionyl chloride, seal it with nitrogen protection, and stir it magnetically for 24 hours. Distill under reduced pressure for 2 to 4 hours until all excess thionyl chloride is evaporated and the product is evaporated to dryness. Add 10ml of CCl to the obtained impure 2,3,5-triiodobenzoyl chloride 4 , The solid was collected by filtration, washed, and freeze-dried to obtain 2,3,5-triiodobenzoyl chloride.

[0028] The infrared spectrum (IR pattern) of 2,3,5-triiodobenzoyl chloride and raw material 2,3,5-triiodobenzoic acid is as follows figure 1 , as can be seen from the figure, 1710cm -1 It is the stretching vibration of 2,3,5-triiodobenzoic acid C=O, 3073cm -1 is the stretching vibration of C-I. After 2,3,55-triiodobenzoic acid reacts with dimethyl sulfoxide to become 2,3,5-triiodobenzoyl chloride, the stre...

Embodiment 2

[0029] Example 2 Preparation of CT / MRI bifunctional ferric oxide nanoparticles

[0030] Take 5 ml of ethanol dispersion of amino-functionalized iron ferric oxide nanoparticles (containing 25 mg of amino-functionalized iron ferric oxide nanoparticles, particle size 2-6 nm), wash with anhydrous tetrahydrofuran and magnetically separate, wash for 5 and then dispersed in 10 ml of anhydrous tetrahydrofuran.

[0031] Vacuumize, protect with inert gas atmosphere, inject 0.22ml (1.43mmol) anhydrous triethylamine under ice bath conditions (-5~0℃), stir magnetically for 30 minutes, and disperse the amino-functionalized Fe3O4 nanoparticles Obtain a magnetic nanoparticle solution; then dissolve 100 mg of 2,3,5-triiodobenzoyl chloride obtained in Example 1 in 5 ml of anhydrous tetrahydrofuran, inject it into the magnetic nanoparticle solution, and stir overnight (14 hours).

[0032] Washed four times with anhydrous tetrahydrofuran magnetic separation, and freeze-dried to obtain CT / MRI dua...

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Abstract

The invention relates to the field of a material and discloses a preparation method of ferroferric oxide nano particles with CT / MRI (Computed Tomography / Magnetic Resonance Imaging) double functions, comprising the following steps of: (1) washing the amino-functionalized ferroferric oxide nano particles by using an organic solvent and dispersing into an organic solvent, vacuumizing and protecting by using nitrogen or inert gas, adding triethylamine at a temperature of -5-0 DEG C, and agitating uniformly; (2) dissolving 2,3,5-triiodobenzoyl chloride into the organic solvent and injecting into a solution of the step (1) and agitating for 10-24 hours; and (3) washing and separating, and freeze-drying the obtained solid to obtain the ferroferric oxide nano particles with the CT / MRI double functions. The grain diameter of the obtained particles is 2-6 nm; and the particles have the advantages of good water solubility, better dispersity and uniform shape, have the CT / MRI double functions and can be used for preparing a contrast agent.

Description

technical field [0001] The invention relates to the field of materials, in particular to ferric oxide nanoparticles with CT / MRI dual functions. Background technique [0002] It has been nearly 40 years since Hounsfied invented CT. The emergence of CT is the product of the combination of traditional X-ray photography and computer technology. CT (Computerized Tomography) - computerized tomography, is a kind of physical quantity (such as Wave velocity, X-ray intensity, electron beam intensity, etc.) projected data, using certain mathematical methods, through computer processing, to reconstruct a two-dimensional image on a specific level of the object and to form a three-dimensional image based on a series of the above-mentioned two-dimensional images. Magnetic resonance imaging is a type of tomography, which uses magnetic resonance phenomena to obtain electromagnetic signals from the human body and reconstruct human body information. In 1946, Flelix Bloch of Stanford Universi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/04A61K49/08
Inventor 杨仕平于艳蓉杨红崔晓贞丁亮汪娟娟陈冬梅
Owner SHANGHAI NORMAL UNIVERSITY