Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Amino-acid dual-chain quaternary-amino carboxylate, preparation method and application in microbicides thereof

A technology of quaternary amino carboxylate and didecyl dimethyl amino carboxylate, which is applied in the field of broad-spectrum, high-efficiency microorganism-killing new compounds and their preparation, and can solve problems such as mutagenesis and reproductive defects

Active Publication Date: 2013-04-03
KUNMING YESHUI BIO TECH LTD
View PDF6 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Benzalkonium chloride, although widely used, may be a mutagen causing reproductive defects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Amino-acid dual-chain quaternary-amino carboxylate, preparation method and application in microbicides thereof
  • Amino-acid dual-chain quaternary-amino carboxylate, preparation method and application in microbicides thereof
  • Amino-acid dual-chain quaternary-amino carboxylate, preparation method and application in microbicides thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Production of Pyroglutamic Acid Didecyl Dimethylaminocarboxylate DAPC (N, N-di-n-decyl-N, N-dimethyl-ammonium 5-oxopyrrolidine-2-carboxylate)

[0075] 1) First weigh 0.03 mol of sodium hydroxide, dissolve it in deionized water to make the solution weigh 30 g, and cool it down.

[0076] 2) Weigh again 0.03 mol of pyroglutamic acid and dissolve it in the above-mentioned 30 g of sodium hydroxide aqueous solution. The reaction product is an aqueous solution of sodium pyroglutamate (solution A).

[0077] 3) Weigh 0.025 mol of didecyl dimethyl ammonium chloride and dissolve it in 160 g of deionized water to obtain solution B.

[0078] 4) Mix liquid A and liquid B thoroughly to obtain solution C.

[0079] 5) The mass of solution C is about 200g.

[0080] 6) Take 200g of solution C, add 400ml of dichloromethane, and add 10g of sodium chloride, stir well, put it into an extraction bottle, shake well, and let it stand for 30 minutes.

[0081] 7) Remove the lower layer and vac...

Embodiment 2

[0085] Make alanine didecyl dimethyl amino carboxylate DAAC (N, N-din-decyl-N, N-dimethyl-ammonium N-acetylated alanine carboxylate)

[0086] (1) First weigh 0.03 mol of sodium hydroxide, dissolve it in deionized water to make the solution weigh 30 g, and cool it.

[0087] (2) Weigh again 0.03 mol of acetylated alanine and dissolve it in 30 g of sodium hydroxide aqueous solution. The reaction product is an aqueous solution of sodium pyroglutamate (solution A).

[0088] (3) Weigh 0.025 mol of didecyl dimethyl ammonium chloride and dissolve it in 160 g of deionized water to obtain solution B.

[0089] (4) Thoroughly mix liquid A and liquid B to obtain solution C.

[0090] (5) The mass of solution C is about 200g.

[0091] (6) Take 200 g of solution C, add 400 ml of dichloromethane, and add 10 g of sodium chloride, stir well, put it into an extraction bottle, shake well, and let it stand for 30 minutes.

[0092] (7) Remove the lower layer liquid and vacuum rotary evaporate fo...

Embodiment 3

[0096] Other amino acid double-chain quaternary amino carboxylates can be prepared by the same method, such as:

[0097] N, N-dimethyl-N, N-di-n-decylammonium N-acetylated proline carboxylate

[0098]

[0099] N, N-dimethyl-N, N-di-n-decylammonium N-acetylated phenylalanine carboxylate

[0100]

[0101] N, N-dimethyl-N, N-di-n-decylammonium N-acetylated serine carboxylate

[0102]

[0103] N, N-dimethyl-N, N-di-n-decylammonium N-acetylated isoleucine carboxylate

[0104]

[0105] N, N-dimethyl-N, N-di-n-decylammonium N-acetylated S-methyl cystine carboxylate

[0106]

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to amino-acid dual-chain quaternary-amino carboxylate, a preparation method and application in microbicides thereof. The amino-acid dual-chain quaternary-amino carboxylate is composed of amino acid anions with negative charges and dual-chain amino cations or the amino acid anions with negative charges and dual-chain quaternary-amino cations excluding halogen elements. The amino-acid dual-chain quaternary-amino carboxylate has a general formula shown in the specification, wherein A-COO<-> represents protected amino acids; A represents different amino acid residue derivatives; R1 represents straight-chain or cyclic-chain substituents; R2 represents aryls which can be substituted by straight chains or cyclic chains or alkoxyls; and R1 and R2 can be the same or different, and the R1 or R2 can be H. New compounds with the general formula can be applied to the prevention and treatment of microbial infection and also applied to environmental disinfection.

Description

technical field [0001] The invention relates to a medicine, in particular to a broad-spectrum, high-efficiency novel compound for killing microorganisms and a preparation method thereof. Background technique [0002] Disinfectants commonly used at present all have different shortcomings, and each has its limitation when being applied. Disinfectants containing active oxygen: such as peracetic acid, hydrogen peroxide, peroxyglutaric acid, chlorine dioxide, etc. Peracetic acid, hydrogen peroxide, and peroxyglutaric acid are unstable and highly irritating, and long-term use will have strong damage to human and animal eyes, respiratory mucosa, and the environment. Chlorine-containing disinfectant: refers to a disinfectant that can produce hypochlorous acid with bactericidal activity in water. Its metabolite chloroform is highly carcinogenic and most of them are highly irritating. Iodine-based disinfectants: various preparations made with iodine as the main bactericidal ingredie...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D207/28C07C211/63C07C209/00C07C233/47C07C231/12C07D207/16C07C323/59C07C319/20A01N43/36A01N33/12A01N37/46A01P1/00
Inventor 陆可望陆可信张磊
Owner KUNMING YESHUI BIO TECH LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com