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Hemostatic or anticoagulant collagen material

A collagen material and collagen technology, which is applied in anticoagulation treatment, peptide preparation method, type of packaging items, etc., can solve the problems of difficult dressing change, no anti-edema, poor toughness, etc., and is conducive to tissue adsorption and entry growth. Effect

Active Publication Date: 2013-04-10
SHANGHAI CINGULAR BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional hemostatic materials commonly used in clinical practice, such as hemostatic gauze, hemostatic fiber, and hemostatic bandage, have limitations in use: the hemostatic time is longer, it is easy to adhere to the wound and it is difficult to change the dressing, and it is powerless to wound infection and suppuration
Pure gelatin sponge or collagen sponge has poor toughness, is not tightly combined with the wound surface, and has no anti-edema effect

Method used

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  • Hemostatic or anticoagulant collagen material
  • Hemostatic or anticoagulant collagen material
  • Hemostatic or anticoagulant collagen material

Examples

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Embodiment Construction

[0039] 1. Under weakly acidic to weakly alkaline conditions (pH6.0-8.0), react collagen with glutaraldehyde (volume concentration 0.1%-2%). The dosage ratio of collagen and glutaraldehyde here is: 1g Collagen plus 1% (v / v) glutaraldehyde 50mL, the reaction process is as follows figure 2 shown. Reaction times range from 30 minutes to 14 days. The resulting collagen substrate is negatively charged in solution and has anticoagulant properties. For example, bovine pericardium was placed in 0.6% (v / v) glutaraldehyde solution in PBS buffer, pH 7.4, for 3 days. Or under alkaline conditions (pH8.0-10.5), react collagen with ethylene glycol diglycidyl ether according to the ratio of 1g collagen plus 2% (v / v) ethylene glycol diglycidyl ether 50mL, ethylene glycol diglycidyl ether The epoxy group in alcohol diglycidyl ether reacts with the ε-amino group of lysine, and the reaction process is as follows image 3 shown. Reaction times range from 1 hour to 14 days. After the reaction ...

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Abstract

The invention relates to a collagen material with a local hemostatic or anticoagulant function. A specific amino acid polar group on a collagen peptide chain, such as carboxyl or amino, reacts, and electrical property of the polar group is changed, so that the local hemostatic material promoting blood coagulation or the anticoagulant material preventing the blood coagulation is designed. The collagen material can be implanted to exert the local hemostatic or anticoagulant effect; cells around an injured site can enter the collagen material to grow; and the healing of an injured tissue is facilitated. The method is simple and easy to operate, and the collagen material is especially suitable for industrial mass production and is also very economical.

Description

technical field [0001] The invention relates to a collagen material and a preparation method thereof, in particular to a collagen material with local hemostatic or anticoagulant functions and a preparation method thereof. Background technique [0002] Collagen is the most abundant protein in many vertebrates and invertebrates. It belongs to structural proteins and is the main fiber component of skin, bone, cartilage, blood vessels and teeth, and is present in all organs. There are currently 28 types of collagen identified, ranging from type I to type XXVIII. Among them, type I collagen has the most content in animals and its immunogenicity is much lower than other types of collagen, so it is the most widely used. The basic structure of collagen is composed of three α-polypeptide chains, each α-chain itself is in a left-handed helical configuration, and the three α-chains are intertwined to form a right-handed superhelical structure. Each α chain is formed by dehydration co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/12C08J7/14C08L89/00A61L33/12A61L31/04A61L31/16C07K1/107
CPCC08J7/12A61L33/12A61K38/39A61L31/04C08J7/14C07K1/107A61K38/02A61L27/24A61L2400/04
Inventor 杨军
Owner SHANGHAI CINGULAR BIOTECH
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