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Application of salvianolic acid A freeze-dried powder injection for preparing medicines for preventing and/or treating cerebral thrombosis

A technology of freeze-dried powder injection and salvianolic acid, which is applied in the field of preparation of drugs for the prevention and/or treatment of cerebral thrombosis, and can solve problems such as the inability to guarantee the pharmacological effects of salvianolic acid A and the instability of injections

Active Publication Date: 2013-05-08
JIANGZI QINGFENG PHARMACEUTICALS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are not many literatures on salvianolic acid A preparations, especially injections, and the instability of injections is common, so the pharmacological effects of salvianolic acid A cannot be guaranteed.

Method used

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  • Application of salvianolic acid A freeze-dried powder injection for preparing medicines for preventing and/or treating cerebral thrombosis
  • Application of salvianolic acid A freeze-dried powder injection for preparing medicines for preventing and/or treating cerebral thrombosis
  • Application of salvianolic acid A freeze-dried powder injection for preparing medicines for preventing and/or treating cerebral thrombosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0107] Take Danshen medicinal material, crush it into 6-mesh granules, add 7 times the amount of 92°C water each time, warm soak and extract 3 times, and stir at a speed of 25 rpm, and warm soak and extract for 3 hours each time; the extract is concentrated under reduced pressure to relative Density 1.20 (60°C), add ethanol to make the alcohol content at 70%, let it stand, filter, the filtrate is decompressed to recover ethanol and concentrate until it has no alcohol smell; add water to dilute to 20mg per 1ml of salvianolic acid B, use 10% for aqueous solution Adjust the pH to 4.0 with sodium hydroxide, add 0.5% ZnCl 2 As a catalyst, heat and transform at 120°C for 4 hours, adjust the pH value of the transformation liquid to 2.5 with 20% phosphoric acid, centrifuge, concentrate the supernatant under reduced pressure to contain 3 mg of salvianolic acid A per 1 ml, and perform HPD-100 macroporous resin column chromatography For separation, the ratio of the loading amount of salv...

Embodiment 2

[0110] Take Salvia miltiorrhiza, crush it into particles with a diameter of about 2mm, add 7 times the amount of 90°C water each time, warm soak and extract 3 times, and stir at a speed of 25 rpm, and warm soak and extract for 3 hours each time; the extract is concentrated under reduced pressure to Relative density 1.18 (60°C), add ethanol to make the alcohol content 70%, let it stand, filter, the filtrate recovers ethanol under reduced pressure and concentrates to no alcohol smell; add water to dilute to contain salvianolic acid B20mg per 1ml, and use 10 mg of salvianolic acid B in the aqueous solution % NaOH to adjust the pH to 5.5, add 0.5% ZnCl 2 As a catalyst, heat and transform at 120°C for 4 hours, adjust the pH value of the transformation liquid to 2.5 with 20% phosphoric acid, centrifuge, concentrate the supernatant under reduced pressure to contain 3 mg of salvianolic acid A per 1 ml, and perform HPD-100 macroporous resin column chromatography For separation, the rat...

Embodiment 3

[0113] Take Salvia miltiorrhiza, cut into decoction pieces, add 8 times the amount each time, soak in water at 85°C for 3 times, stir at a speed of 20 rpm, and extract with warm soaking for 2.5 hours each time; the extract is concentrated under reduced pressure to a relative density of 1.17 (60 ℃), add ethanol to make the alcohol content at 75%, let it stand, filter, the filtrate recovers ethanol under reduced pressure and concentrates to no alcohol smell; add water to dilute to contain salvianolic acid B15mg per 1ml, and adjust the aqueous solution with 10% hydroxide bell pH to 5.0, add 0.6% ZnCl 2 As a catalyst, heat conversion at 120°C for 3.5 hours, adjust the pH value of the conversion liquid to 2.5 with 15% hydrochloric acid, centrifuge, concentrate the supernatant under reduced pressure to contain 5 mg of salvianolic acid A per 1 ml, pass through HPD-100 macroporous resin column layer Analysis and separation, the ratio of the loading amount of salvianolic acid A to the ...

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Abstract

The invention relates to application of a salvianolic acid A freeze-dried powder injection for preparing medicines for preventing and / or treating cerebral thrombosis. The salvianolic acid A freeze-dried powder injection comprises 10-80g of main raw material containing salvianolic acid A, 10-80g of filler and 0.01-0.2 wt% of antioxidant, wherein the filler is any one or more of mannitol, glucose and lactose; the antioxidant is selected from any one or more of vitamin C, thiocarbamide, sodium bisulfite and sodium metabisulfite; and the main raw material containing salvianolic acid A comprises greater than 93% and less than 100% of salvianolic acid A, 0.1-2% of alkannic acid, 0.1-2% of rosmarinic acid, 0.1-2% of salvianolic acid B and 0.1-2% of salvianolic acid C.

Description

technical field [0001] The invention relates to the use of salvianolic acid A freeze-dried powder for preparing medicines for preventing and / or treating cerebral thrombosis. technical background [0002] Cerebrovascular disease, also known as stroke, is a neurological disease caused by various causes of blood vessels supplying the brain. The main cause is cerebral arterial lumen stenosis, vasospasm, occlusion or rupture, reduced or complete blockage of blood flow, brain blood circulation and dysfunction caused by cerebral arterial system damage (such as cerebral arteriosclerosis), and brain tissue damage. A series of symptoms caused by damage. Mainly including ischemic and hemorrhagic cerebrovascular diseases. Among them (ICVD, also known as ischemic stroke) accounted for about 80%. [0003] Ischemic cerebrovascular disease refers to the degeneration, necrosis or transient loss of function of local brain tissue including nerve cells, glial cells and connecting fibers due ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/216A61K31/343A61K47/26A61P7/02A61J3/02C07C69/732
Inventor 杨小玲廖祝元程帆刘恩位王振汤新乾
Owner JIANGZI QINGFENG PHARMACEUTICALS INC
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