Preparation method of synergistic sulfamethoxypyridazine injection for livestock

A technology of sulfamethoxypyridazine and injection, which is applied in the field of veterinary compound sulfamethoxypyridazine injection and its preparation, can solve the problems of unsatisfactory treatment effect, short residence time, strong irritation, etc., and improve product quality. Added value, less usage, less irritating effect

Inactive Publication Date: 2013-05-08
金河牧星(重庆)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The clinical manifestations of these diseases are infectious, high fever and inflammation. The treatment effect of compound sulfamethoxypyridazine injection recorded in the Pharmacopoeia is not ideal, and it is usually injected twice a day, which is highly irritating and has a large dose.
The main reason may be that the blood residence time of sulfamethoxypyridazine itself is relatively short, resulting in short drug effect and large dosage.

Method used

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  • Preparation method of synergistic sulfamethoxypyridazine injection for livestock
  • Preparation method of synergistic sulfamethoxypyridazine injection for livestock
  • Preparation method of synergistic sulfamethoxypyridazine injection for livestock

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1. Formula

[0033] Sulfamethoxypyridazine: 10g, trimethoprim: 2g, indomethacin: 2g, sodium thiosulfate: 0.1g, polyethylene glycol 8000: 5g, propylene glycol 30ml, 10ml of hydroxide with a concentration of 1mol / L One part each of sodium solution and 0.5mol / L hydrochloric acid for later use, and 55ml of water for injection.

[0034] 2: Preparation method

[0035] In the first step, take water for injection and heat it to 50-60°C, add sodium thiosulfate and polyethylene glycol 8000 respectively, stir to dissolve them all, adjust the pH value to about 10 with sodium hydroxide solution, and prepare A liquid for later use ;

[0036] In the second step, take propylene glycol, heat to 60-70°C, add sulfamethoxypyridazine, trimethoprim, and indomethacin respectively, stir to dissolve them all, and prepare liquid B;

[0037] In the third step, add liquid A into liquid B and stir evenly, continue to stir for 30 minutes, and adjust the pH value to 9.5-10.5; first filter with an ...

Embodiment 2

[0040] 1. Formula

[0041] Sulfamethoxypyridazine: 15g, trimethoprim: 3g, indomethacin: 3g, sodium thiosulfate: 0.15g, polyethylene glycol 8000: 7.5g, propylene glycol 35ml, 10ml of hydrogen with a concentration of 1mol / L Sodium oxide solution and 0.5mol / L hydrochloric acid each one for standby, water for injection 50ml.

[0042] 2: Preparation method

[0043] In the first step, take water for injection and heat it to 50-60°C, add sodium thiosulfate and polyethylene glycol 8000 respectively, stir to dissolve them all, adjust the pH value to about 10 with sodium hydroxide solution, and prepare A liquid for later use ;

[0044]In the second step, take propylene glycol, heat to 60-70°C, add sulfamethoxypyridazine, trimethoprim, and indomethacin respectively, stir to dissolve them all, and prepare liquid B;

[0045] In the third step, add liquid A into liquid B and stir evenly, continue stirring for 30 minutes, and adjust the pH value to 9.5-10.5. Filtrating with an organic fi...

Embodiment 3

[0048] 1. Formula

[0049] Sulfamethoxypyridazine: 15g, trimethoprim: 3g, indomethacin: 3g, sodium bisulfite: 0.15g, polyethylene glycol 8000: 7.5g, propylene glycol 30ml, 10ml of hydrogen with a concentration of 1mol / L Sodium oxide solution and 0.5mol / L hydrochloric acid each one for standby, water for injection 55ml.

[0050] 2: Preparation method

[0051] In the first step, take water for injection and heat it to 50-60°C, add sodium bisulfite and polyethylene glycol 8000 respectively, stir to dissolve them all, adjust the pH value to 9.5, and prepare A liquid for later use;

[0052] In the second step, take propylene glycol, heat to 60-70°C, add sulfamethoxypyridazine, trimethoprim, and indomethacin respectively, stir to dissolve them all, and prepare liquid B;

[0053] In the third step, add liquid A into liquid B and stir evenly, continue stirring for 30 minutes, and adjust the pH value to 9.5-10.5. Filtrating with an organic filter membrane with a diameter of 0.45 mic...

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PUM

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Abstract

The invention relates to a compound sulfamethoxypyridazine injection and a preparation method thereof. The synergistic sulfamethoxypyridazine injection has enduring drug effect and obvious curative effect. The injection comprises the following components in parts by weight: 10-20 parts of sulfamethoxypyridazine, 2-4 parts of indometacin, 2-4 parts of trimethoprim, 5-10 parts of polyethyleneglycol 8000, 30-40 parts of propanediol, 0.1-0.2 part of antioxidant, 30-55 parts of water for injection, and sufficient amount of pH regulator for regulating the pH value of the system to 9.5-10.5. The preparation method comprises the following steps: adding the antioxidant into the water for injection to prepare a solution A, adding the polyethyleneglycol 8000, sulfamethoxypyridazine, indometacin and trimethoprim into the propanediol, and completely dissolving by stirring to prepare a solution B; and merging, filtering, packaging and sterilizing to obtain the finished product. The injection provided by the invention is a new drug preparation with triple effects, and has the advantages of long drug effect, low consumption, low application frequency, small irritation, quick drug effect taking and wide curative range.

Description

technical field [0001] The invention relates to a veterinary drug, in particular to a veterinary compound sulfamethoxypyridazine injection and a preparation method thereof. Background technique [0002] Sulfonamides have been used clinically for decades. Sulfamethoxypyridazine (SMP) is one of the main varieties of sulfonamides and is effective against most Gram-positive bacteria and some Gram-negative bacteria. , especially Streptococcus, Staphylococcus, Pneumococcus, Escherichia coli, Listeria and other sensitive bacteria infection, also effective for Chlamydia and some protozoa, it is a broad-spectrum antibacterial agent. The maintenance time of effective plasma concentration is 24 hours for buffaloes, 5.8 hours for pigs, 7 hours for goats and 2 hours for sheep. This product is suitable for systemic infection caused by various animal sensitive bacteria. It has definite curative effect, stable properties, easy to use, cheap price and convenient long-term storage. It is th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/635A61K31/405A61K31/505A61K9/08A61P31/04A61P33/02A61P11/06A61P29/00
Inventor 胡学全秦斌
Owner 金河牧星(重庆)生物科技有限公司
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