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Dual-mode synergistically-enhanced magnetic-resonance contrast agent and method for synthesizing same

A technology of magnetic resonance contrast agent and synthesis method, which is applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agent, etc., can solve the problems of unsatisfactory dual-mode imaging effects and achieve high-accuracy results

Inactive Publication Date: 2013-05-22
XIAMEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in this method T 1 The magnetization direction of the contrast material is exactly at T 2 The opposite direction of the magnetization vector line of the contrast material weakens each other, so the dual-mode imaging effect is not ideal ([1] J.S.Choi, J.H.Lee, T.H.Shin, H.T.Song, E.Y.Kim, J.Cheon, J.Am. Chem.Soc.2010, 132, 11015; [2] H.Yang, Y.M.Zhuang, Y.Sun, A.T.Dai, X.Y.Shi, D.M.Wu, F.Y.Li, H.Hu, S.P.Yang, Biomaterials2011, 32, 4584.)

Method used

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  • Dual-mode synergistically-enhanced magnetic-resonance contrast agent and method for synthesizing same
  • Dual-mode synergistically-enhanced magnetic-resonance contrast agent and method for synthesizing same
  • Dual-mode synergistically-enhanced magnetic-resonance contrast agent and method for synthesizing same

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Embodiment 1

[0029] Example 1: Preparation of gadolinia-doped iron oxide nanoparticles (Gd:Fe=1:10) with a diameter of 14 nm

[0030]In a 50mL three-neck flask, add 0.9g ferric oleate and 0.1g gadolinium oleate (Gd:Fe=1:10), dissolve with 15mL octadecene, and add 0.2mL oleic acid at the same time. The air in the reaction flask was replaced with nitrogen, and this was repeated 3 times. Then heated to reflux temperature and maintained for 1 hour, the reaction stopped, and the reaction solution was naturally cooled to room temperature. Add 40 mL of isopropanol to the reaction liquid, centrifuge at 6000 rpm for 10 min, and discard the supernatant. The obtained precipitate was redissolved in 10 mL of n-hexane to obtain gadolinium-doped iron oxide nanoparticles with a diameter of about 14 nm. figure 2 The low-resolution and high-resolution (upper right image) transmission electron microscope images of gadolinia-doped iron oxide nanoparticles with a diameter of 14 nm prepared in Example 1 are ...

Embodiment 2

[0031] Example 2: Preparation of gadolinia-doped iron oxide nanoparticles (Gd:Fe=1:20) with a diameter of 3 nm

[0032] In a 50 mL three-neck flask, add 0.176 g of iron acetylacetonate and 0.16 g of gadolinium oleate (Gd:Fe=1:20), dissolve in 15 mL of benzoic ether, add 0.6 mL of oleic acid, 0.6 mL of oleylamine and 0.39 g of 1, 2-Hexadecyl glycol. The air in the reaction flask was replaced with nitrogen, and this was repeated 3 times. Then heated to reflux temperature and maintained for 0.5 hours, the reaction stopped, and the reaction solution was naturally cooled to room temperature. Add 40 mL of ethanol to the reaction solution, centrifuge at 6000 rpm for 10 min and discard the supernatant. The obtained precipitate was redissolved in 10 mL of n-hexane to obtain gadolinium-doped iron oxide nanoparticles with a diameter of about 3 nm.

[0033] image 3 The low-resolution and high-resolution (upper right image) transmission electron microscope images of gadolinia-doped ir...

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Abstract

The invention relates to a contrast agent and particularly relates to a dual-mode synergistically-enhanced magnetic-resonance contrast agent and a method for synthesizing the same. The dual-mode synergistically-enhanced magnetic-resonance contrast agent is synthesized in one pot by taking the compound of a contrasting material T1 and a contrasting material T2 as a reaction precursor. The method comprises the following steps of: dissolving gadolinium oleate or gadolinium acetylacetone and ferric oleate or ferric acetylacetonate into octadecene or benzyl ether, adding oleic acid, heating an obtained solution, carrying out reflux reaction to obtain a reaction solution, cooling to room temperature, adding a first solvent to precipitate a product of reaction, centrifuging, removing a supernate, and dissolving a precipitate into a second solvent. The method is simple in steps, is convenient to operate, ensures high yield and is suitable for large-scale preparation. The idea of doping and synthesizing ensures that the field directions of the contrasting material T1 and the contrasting material T2 are parallel and same in the external magnetic field. The dual-mode contrast agent synthesized from the contrasting material T1 and the contrasting material T2 has the capacity of making two imaging modes complementary to each other and can obtain two imaging results nearly at the same time in the same place under the same resolution.

Description

technical field [0001] The invention relates to a contrast agent, in particular to a dual-mode synergistically enhanced magnetic resonance contrast agent and a synthesis method thereof. Background technique [0002] The development of nanotechnology has brought great changes to the development of various scientific research fields such as chemistry, physics, biology, medicine and energy. For example, the paramagnetic or ferromagnetic properties of magnetic nanomaterials can be used as excellent contrast agents for magnetic resonance imaging, which can effectively improve the accuracy of clinical diagnosis of diseases using magnetic resonance imaging techniques. Feridex, a magnetic resonance imaging material already on the market, is a dextran-wrapped ferric oxide nanoparticle, which can be used as a good transverse relaxation imaging (hereinafter referred to as T 2 Imaging) contrast agents improve the bright contrast between diseased and normal tissues, thereby improving th...

Claims

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Application Information

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IPC IPC(8): A61K49/06
Inventor 高锦豪周子健王效民尹震宇池小琴杨丽娇
Owner XIAMEN UNIV
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