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Skin rolling needle

A technology of needle rolling and skin, which is applied in the fields of cosmetology and medicine, can solve the problems such as the structure and application of painless skin rolling needle products that have not yet been discovered, and achieve the effects of improved maneuverability, symmetrical and stable force, and simple operation

Inactive Publication Date: 2013-05-29
上海百华生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0097] Through literature search, etc., so far, no newer reports on painless skin rolling products and their structure and use have been found.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0153] Example 1. Research on the relationship between microneedle application strength and depth

[0154] Utilize the device of technical scheme of the present invention, specific content is as follows:

[0155] Eight pieces of isolated back skin of nude mice were taken and treated with modified skin roller needles (needle length 500 μm). The force used is 2.5, 5, 7.5, 10, 12.5, 15, 17.5, 20N, and the force is controlled by an electronic balance. Then stain with methylene blue solution for 2 minutes, and wash away the dye solution with water. After wiping off the water and residual dye with a dry cotton ball, cut the above skin into small pieces of 1 cm × 0.5 cm, then immerse the tissue in OCT liquid and freeze it at low temperature in liquid nitrogen for overnight. The length of the pinhole and record. Experimental results (table 1, image 3 ):

[0156] After the modification of the microneedle roller, the protective cover makes the skin smooth during use, making rollin...

Embodiment 2

[0159] Example 2. Study on the Effectiveness of Transdermal Administration (Franz Diffusion Cell Method)

[0160] Utilize the device of technical scheme of the present invention, specific content is as follows:

[0161] Take 2 pieces of nude mouse skin, remove the subcutaneous tissue, and rinse with normal saline. The blank group was not treated with microneedles, and the experimental group was treated with modified microneedle rollers. The skin of the blank group and the experimental group was fixed between the Franz administration chamber and the receiving chamber, the stratum corneum faced the administration chamber, and the effective penetration area was 0.85cm 2 . Add hydroalcoholic solution (isopropanol: normal saline = 1:1) into the receiving chamber until it is in close contact with the skin (4ml), remove air bubbles, place in a constant temperature water bath at (37.0±0.5)°C, (200±1)r / min constant speed electromagnetic stirring. Apply 0.2g retinoic acid cream on ...

Embodiment 3

[0166] Embodiment 3, skin irritation research

[0167] Utilize the device of technical scheme of the present invention, specific content is as follows:

[0168] After nude mice were anesthetized, they were treated with a modified microneedle roller, and the nude mice were killed 3 days after the treatment. The skin tissue administered percutaneously was fixed with 10% formaldehyde (diluted in PBS), dehydrated with ethanol, embedded in paraffin, sectioned (5 μm), and mounted On the glass slide, stained with HE, observe the tissue reaction and inflammatory cells under the microscope, and take pictures. The control group was not treated with microneedling.

[0169] HE staining process:

[0170] ① Stain with hematoxylin solution for 5-15 minutes.

[0171] ②Rinse with running water for 3~5 minutes.

[0172] ③The 0.5~1% hydrochloric acid alcohol solution differentiates for a few seconds.

[0173] ④Rinse with running water, and the weak alkaline aqueous solution will appear blue...

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Abstract

The invention relates to a painless skin rolling needle used for fast cutaneous penetration or cosmetic products. A handle and a support of the fixing frame of the device are movably connected in a multidirectional sliding or multi-angle moving embedded mode, a rolling wheel seat is a hollow column cylinder, transdermal drug delivery, transdermal absorption and controlled-release system are improved, large numbers of micro pipelines can be formed through the rolling needle in a short time, medicines, the cosmetic products and the like are directly penetrated through epidermal cells, an epidermal wound is micro and is fast healed, and possibilities of bacterial infection are remarkably lowered. Skin hardening and cell shrinkage cannot be caused, an epidermal tissue also cannot become thin, and the skin rolling needle can be used for multiple times and further can be used for scalp massage to stimulate hairs to grow. The skin rolling needle is simple in preparation process, low in cost and side effect, obvious in effect, good in controllability, convenient to use, strong in practicality, capable of being directly used for daily life, suitable for large-scale production and commercial application in medical and cosmetic industries, and remarkable in benefit. In addition, a user can master the skin rolling needle through simple training.

Description

technical field [0001] The present invention relates to technical fields such as medicine and cosmetology, in particular to a painless drug delivery device for transdermal administration of medicines and beauty products, and its structure and application, and more specifically to a device for transdermal drug delivery. Painless skin rolling needles for rapid transdermal absorption or sustained release of medicine or beauty products, as well as their structure and application. Background technique [0002] (1) Research overview of microneedle rollers [0003] 1 Overview [0004] In the 21st century, the medical field is facing a new problem in the field of medicine: how to correctly deliver the drug to the site where it needs to be treated, so as to maximize the efficacy of the drug. The beauty industry is also facing the same problem. Why are some high-tech nanotechnology, first-class raw materials and expensive beauty creams and beauty creams after use, the effect is not ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/0023
Inventor 袁立勇张立超管孝君李玲庹焱
Owner 上海百华生物科技有限公司
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