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Preparation method for nanoparticle pharmaceutical composition, and nanoparticle pharmaceutical composition

A nanoparticle and composition technology, applied in the field of nanoparticle medicine, can solve the problem of difficult control of the content ratio of drug compounds

Inactive Publication Date: 2013-06-12
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to overcome the defect that the content ratio of each drug compound is difficult to control in the existing nanoparticle pharmaceutical composition, the present invention provides a method for preparing a nanoparticle pharmaceutical composition that can control the content ratio of each drug compound according to demand. Preparation method and nanoparticle pharmaceutical composition prepared by the method

Method used

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  • Preparation method for nanoparticle pharmaceutical composition, and nanoparticle pharmaceutical composition
  • Preparation method for nanoparticle pharmaceutical composition, and nanoparticle pharmaceutical composition
  • Preparation method for nanoparticle pharmaceutical composition, and nanoparticle pharmaceutical composition

Examples

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preparation example Construction

[0021] The invention provides a method for preparing a nanoparticle pharmaceutical composition, the nanoparticle pharmaceutical composition contains amphiphilic polymers, cationic polymers, hydrophobic drugs, hydrophilic small molecule drugs and nucleic acid drugs, the method comprising The following steps:

[0022] (1) Under the condition of ultrasonic radiation, the first solution is mixed and emulsified with the aqueous solution of the hydrophilic small molecule drug to obtain the first emulsion;

[0023] The first solution contains the amphiphilic polymer and a first organic solvent; the first organic solvent is capable of dissolving the amphiphilic polymer, but is insoluble in water, and does not mix with the described amphiphilic polymer under emulsifying conditions. an organic solvent for the chemical reaction of the amphiphilic polymer, the hydrophobic drug, the hydrophilic small molecule drug and the nucleic acid drug;

[0024] (2) mixing the first emulsion with the ...

Embodiment 1

[0071] In this example, the nanoparticle pharmaceutical composition was prepared according to the following steps.

[0072] (1) 20 mg of amphiphilic polymer (polyethylene glycol monomethyl ether-polylactic acid-glycolic acid, PLGA-PEG, purchased from Jinan Daigang Biotechnology Co., Ltd., the polyethylene glycol monomethyl ether-poly The hydrophilic group of the lactic acid-glycolic acid copolymer is a polyethylene glycol monomethyl ether group, and the hydrophobic group is a polylactic acid-glycolic acid group, and the polyethylene glycol monomethyl ether-polylactic acid-glycolic acid copolymerization The arrangement of the repeating units of the compound is a block, wherein the molar ratio between the ethylene glycol unit and the lactic acid-glycolic acid unit is 1:1-1:8, and the weight average measured according to the method specified in SHT 1759-2007 Molecular weight is 10 4 -1.5×10 5 ) was dissolved in 1 ml of the first organic solvent (dichloromethane) to obtain the f...

Embodiment 2

[0090] In this example, the nanoparticle pharmaceutical composition is prepared according to the method of Example 1, the difference is that the concentration of doxorubicin in the aqueous solution of the hydrophilic small molecule drug is 0.4 mg / ml, and the concentration of paclitaxel in the second solution is The concentration of the nucleic acid drug is 10 mg / ml, and the dosage of the nucleic acid drug is 0.05 mg.

[0091] According to the same measurement method as in Example 1, the particle size of the nanoparticle pharmaceutical composition obtained in this embodiment is measured by a laser particle size analyzer to be about 200nm; The content of mycin was 0.0005 g, the content of paclitaxel was 0.5 g, and the content of siRNA was 0.000045 g.

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Abstract

The invention provides a preparation method for a nanoparticle pharmaceutical composition. The method comprises the following steps of (1) mixing and emulsifying a first solution with an aqueous solution of hydrophilic small molecule drugs to obtain a first emulsion, wherein the first solution comprises an amphiphilic polymer and a first organic solvent; (2) mixing the first emulsion with an aqueous solution of a first surfactant, mixing the mixed materials with a second solution and an aqueous solution of a cationic polymer and emulsifying to obtain a second emulsion, wherein the second solution contains hydrophobic drugs and a second organic solvent; (3) mixing the second emulsion with an aqueous solution of a second surfactant, carrying out centrifugal separation to obtain a precipitate; and (4) dissolving the precipitate in water and mixing the dissolved precipitate with nucleic acid drugs, and separating to obtain the nanoparticle pharmaceutical composition. The invention also provides the nanoparticle pharmaceutical composition prepared by the above method.

Description

technical field [0001] The invention relates to the field of nanoparticle medicine, in particular to a method for preparing a nanoparticle medicine composition and the nanoparticle medicine composition prepared by the method. Background technique [0002] Nano-drug delivery system refers to the drug delivery system formed by drugs and nano-carriers with a particle size ranging from 1-1000nm, including nanospheres, nanocapsules, nanoparticles and nanoliposomes. Compared with other drug carriers, the nano-drug delivery system has significant advantages: (1) ultra-small volume, which can pass through the smallest capillaries in the human body, and is not easily cleared by phagocytic cells, prolonging the residence time in the circulatory system; (2) ) reach target sites such as the liver, spleen, lung, bone marrow, and lymph where the reticuloendothelial system is concentrated; (3) can penetrate the interstitial space and be absorbed by cells, which is conducive to transdermal ...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/34A61K31/136A61K31/337A61K31/704A61K31/713A61K47/36A61P35/00
Inventor 聂广军王海吴雁
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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