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Method for extracting hesperidin and synephrine from immature bitter oranges

A technology of hesperidin and citrus aurantium is applied in the field of separation of natural products to achieve the effects of low price, easy planting and increased added value

Active Publication Date: 2013-06-26
花垣恒远植物生化有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current published literature has not comprehensively developed and utilized the active ingredients in the extraction process, so the comprehensive deep processing of tangerine peel is of great significance. It is of great significance to explore the simultaneous extraction of synephrine and hesperidin from tangerine peel

Method used

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  • Method for extracting hesperidin and synephrine from immature bitter oranges
  • Method for extracting hesperidin and synephrine from immature bitter oranges
  • Method for extracting hesperidin and synephrine from immature bitter oranges

Examples

Experimental program
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Effect test

Embodiment 1

[0038] Choose Citrus aurantium with a synephrine content of 1.34% and a hesperidin content of 4.94%, dry it, crush it to below 10 mesh, weigh 100kg, add 400L of petroleum ether to mix, reflux at 70°C for 40min, and ceramic membrane Filtrate once to obtain the filtrate, and then concentrate under reduced pressure to remove petroleum ether to obtain Citrus aurantium essential oil. Mix the filter residue of Citrus aurantii with 250L of 20% ethanol aqueous solution, wherein the ethanol aqueous solution also contains 0.0001mol / L NaOH, mix, reflux and extract at 45°C for 40min, filter once with a ceramic membrane to obtain the filtrate, repeat once more, and combine the filtrate to obtain 400L of mixed extract. Concentrate the extract to obtain 50L concentrated solution I, which is adsorbed on KLFC-150 macroporous resin, and eluted with ethanol aqueous solution containing 40% ethanol and 0.001mol / L NaOH to obtain 120L eluent I, and The eluent I was concentrated under reduced pressur...

Embodiment 2

[0040] Choose the content of synephrine in Fructus Aurantium Fructus at 1.34%, the content of hesperidin at 4.94%, dry and pulverize Fructus Fructus Fructus Fructus Fructus Aurantii to below 10 orders and weigh 200kg, add 800L of aqueous solution containing 0.001mol / LNaOH, 45% ethanol to carry out Mix, reflux extraction at 40°C; mix Citrus aurantii filter residue with 400L of 20% ethanol aqueous solution, in which the ethanol aqueous solution also contains 0.0001mol / L NaOH, mix, reflux extraction at 45°C for 40min, filter once with a ceramic membrane to obtain filtrate, repeat once more, and combine The filtrate was mixed extract 700L. Concentrate the extract to obtain 80L concentrated solution I, which is adsorbed on KLFC-150 macroporous resin, and eluted with ethanol aqueous solution containing 40% ethanol and 0.001mol / L NaOH to obtain 250L eluent I, and The eluent I was concentrated under reduced pressure at 50°C to 25 L to obtain the concentrated solution II. Then, KLFC-1...

Embodiment 3

[0042] Choose the synephrine content in 1.34% and the hesperidin content in citrus citrus aurantium to be 4.94%, dry and pulverize the citrus aurantium to below 10 mesh and weigh 400kg, add 1400L containing 0.001mol / LNaOH, 45% ethanol aqueous solution to carry out Mix, reflux extraction at 40°C; mix Citrus aurantii filter residue with 500L of 20% ethanol aqueous solution, in which the ethanol aqueous solution also contains 0.0001mol / L NaOH, mix, reflux extraction at 45°C for 40min, filter once with a ceramic membrane to obtain filtrate, repeat once more, and combine The filtrate was mixed extract 900L. Concentrate the extract to obtain 100L concentrated solution I, which is adsorbed on KLFC-150 macroporous resin, and eluted with ethanol aqueous solution containing 40% ethanol and 0.001mol / L NaOH to obtain 450L eluent I, and The eluent I was concentrated under reduced pressure at 50°C to 50 L to obtain the concentrated solution II. Then, KLFC-150 macroporous resin was eluted w...

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Abstract

The invention relates to a process technology for extracting hesperidin and synephrine from immature bitter oranges. The process technology comprises the following steps of: degreasing the dried immature bitter oranges through petroleum ether and carrying out high-oxidation catalyst by utilizing a diluted alkali solution; filtering and concentrating to be dry; dissolving by utilizing acid water; and adsorbing by resin, eluting by steps, and concentrating and crystallizing to prepare pure products of the hesperidin and the synephrine. The method is simple in operation, greatly improves the yield of the hesperidin and the synephrine, greatly reduces the production cost of the hesperidin and the synephrin, simplifies a production process, and can obtain a lot of oil substances. The immature bitter oranges are used as extraction raw materials so that the utilization efficiency of the immature bitter oranges is greatly improved and the additional value of the immature bitter oranges is improved.

Description

Technical field [0001] The invention relates to a technology for extracting hesperidin and synephrine from Citrus aurantium, belonging to the technical field of natural product separation. Background technique [0002] my country's citrus resources and output rank third in the world, with an output of 10.78 million tons, which are cultivated all over the country. Citrus aurantium is the dry young fruit of sour orange and its cultivars or sweet orange of Rutaceae plant, mainly produced in Sichuan, Jiangxi, Fujian, Jiangsu and other places. Pick or collect the self-falling fruit between May and June, cut it into two halves from the middle, sun-dry or low-temperature drying, and the smaller ones are directly sun-dried or low-temperature drying. When used, wash, suffocate, cut into thin slices, and dry. Used raw or fried with bran. [0003] Citrus is easy to form flowers, but the fruit setting rate is low, generally 3%-5%, high-yield trees can reach about 10%, and low-yield t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08C07C215/60C07C213/10C11B1/10C11B9/02
Inventor 向华
Owner 花垣恒远植物生化有限责任公司
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