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A method for preparing hydrophobic drug nanoparticles by ice template method

A hydrophobic drug and nanoparticle technology, which is applied in the direction of making drugs into special physical or taking forms of devices, etc., can solve the problem that multi-component drugs or imaging contrast agents are difficult to enter the same dosage form, the design of carrier particles is difficult, and the cost of synthesis Advanced problems, to achieve the effect of adjustable components and proportions, high yield, and mild experimental conditions

Inactive Publication Date: 2014-10-22
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the weight of the carrier is often much higher than the weight of the loaded drug molecules, so that the carrier accounts for a large part of the weight in the drug particle, resulting in a low drug loading capacity of the overall composite particle system; in the process of designing drug nanoparticles, the carrier It often brings problems such as biological toxicity and in vivo metabolism; in addition, although the carrier can coat the drug well, it also brings difficulties in understanding adsorption, high cost and time-consuming synthesis, and difficulty in multi-component drugs or imaging contrast agents. Problems such as difficulty in entering the same dosage form, these problems make the choice of carrier and the design of particles difficult
In general, the drug materials selected for carrier loading are materials with good water solubility, but most of the drugs with strong fat solubility and poor water solubility are difficult to use carrier loading, which makes this preparation method have certain limitations

Method used

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  • A method for preparing hydrophobic drug nanoparticles by ice template method
  • A method for preparing hydrophobic drug nanoparticles by ice template method
  • A method for preparing hydrophobic drug nanoparticles by ice template method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The method for preparing anticancer drug teniposide (VM-26) nanoparticles by ice template method is as follows: 1) Preparation of ice template: take a weighing bottle or petri dish, add 5mL high-purity water, put it in the refrigerator and freeze it at the freezing temperature at -5°C, take it out after freezing for 5 hours, and blow off the crushed ice powder on the ice layer to form an ice template with a smooth surface;

[0028] 2) Preparation of drug nanoparticles: Dissolve the hydrophobic anticancer drug teniposide (VM-26) in tetrahydrofuran (THF) to make a 10mM solution, and drop a small amount onto the ice template drop by drop with a disposable dropper surface, and blow it repeatedly with the ear washing ball, so that the low-boiling organic solvent THF evaporates quickly, repeat this operation 3 times, and finally put it in the freezer of the refrigerator for 24 hours, and the freezing temperature is -5°C;

[0029] 3) Remove the template: take the ice template ...

Embodiment 2

[0032] Tetrapyridylporphyrin (H 2 TPyP) nanoparticles method, the method is as follows:

[0033] 1) Prepare the ice template: take a weighing bottle or petri dish, add 5mL of high-purity water, put it in the refrigerator to freeze at -10°C, take it out after freezing for 10 hours, and blow off the crushed ice powder on the top of the ice, That is, an ice template with a smooth surface is formed;

[0034] 2) Preparation of drug nanoparticles: the hydrophobic tetrapyridyl porphyrin (H 2 TPyP) was dissolved in tetrahydrofuran (THF) to make a 10mM solution. Use a disposable dropper to drop a small amount onto the surface of the ice template drop by drop, and blow it repeatedly with an ear wash ball to make the low-boiling organic solvent THF evaporate quickly. Repeat This operation is performed 3 times, and finally put it into the freezer of the refrigerator for 15 hours, and the freezing temperature is -10°C;

[0035] 3) Remove the template: take the ice template out of the re...

Embodiment 3

[0038] The method for preparing anticancer drug curcumin (CCM) nanoparticles by ice template method is as follows:

[0039] 1) Prepare the ice template: take a weighing bottle or petri dish, add 5mL of high-purity water, put it in the refrigerator to freeze at -15°C, take it out after freezing for 24 hours, and blow off the crushed ice powder on the top of the ice, That is, an ice template with a smooth surface is formed;

[0040] 2) Preparation of drug nanoparticles: Dissolve the hydrophobic anticancer drug curcumin (CCM) in acetone to make a 1.5mM solution, use a disposable dropper to drop a small amount onto the surface of the ice template, and wash the ear with a ball Blow repeatedly to make the low-boiling organic solvent acetone evaporate quickly, repeat this operation 5 times, and finally put it in the freezer of the refrigerator for 5 hours, and the freezing temperature is -15°C;

[0041] 3) Remove the template: After 5 hours, take the ice template out of the refriger...

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Abstract

The invention discloses a method for preparing hydrophobic drug nanoparticles by the ice template method. The method includes following steps: 1), preparing an ice template; 2), preparing nanoparticles: enabling drugs to be prepared into a solution at corresponding concentration in organic solvent, dropwise adding the solution on the ice template prepared in former step, and freezing after the organic solvent is volatilized; 3), removing the ice template, and enabling ice to be melted; and 4), collecting the nanoparticles: subjecting liquid obtained by melting in the step 3) to ultrasonic treatment to obtain monodispersed nanoparticles uniform in size. The method for preparing nanodrugs is simple in operation, low in cost, high in yield, adjustable in composition and proportion of the nanodrugs, small and uniform in size of the nanodrugs, free of environment pollution, and free of side effect during template removal, provides material basis and technical guarantee for development and application research of new-generation anticancer drug preparations with high drug-loading capacity, can be used in the field of cancer diagnosis and treatment, and has wide application prospect.

Description

technical field [0001] The invention relates to a method for preparing anticancer drug molecular nanostructures, in particular to a method for preparing hydrophobic drug nano particles by using ice as a template. Background technique [0002] At present, cancer has become the second largest killer of human health, among which chemotherapy is the main treatment. However, chemotherapy has many side effects. Most anticancer drugs have poor water solubility, poor selectivity to tumor tissue, low curative effect, and high toxicity. In order to increase the anti-cancer effect and reduce the toxic and side effects, many scientists around the world are competing to develop the latest nano-drug carrier materials and technologies, including early cancer diagnosis, accurate tumor localization, accurate delivery of anti-cancer drugs to the lesion site, and drug efficacy Real-time in vivo monitoring, etc., in order to fundamentally change the current status of cancer diagnosis, treatmen...

Claims

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Application Information

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IPC IPC(8): A61J3/00
Inventor 张晓宏张金凤
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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