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Preparation method of magnetic microspheres

A microsphere and magnetic technology, applied in the field of preparation of magnetic microspheres, can solve the problems of uneven distribution of magnetite and large particle size distribution of magnetic microspheres, and achieve excellent magnetic responsiveness, uniform particle size, and excellent redispersion. sexual effect

Inactive Publication Date: 2013-07-24
HEILONGJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The purpose of the present invention is to solve the problem that the magnetic microspheres prepared by the existing method have a large particle size distribution and the magnetite in each microsphere is unevenly distributed, and provide a method for preparing magnetic microspheres

Method used

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  • Preparation method of magnetic microspheres
  • Preparation method of magnetic microspheres
  • Preparation method of magnetic microspheres

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specific Embodiment approach 1

[0019] Specific embodiment one: the preparation method of magnetic microspheres in this embodiment is realized according to the following steps:

[0020] 1. Add 70-80mL of ethylene glycol into a 100mL round-bottomed flask, and add 2-3g of FeCl under magnetic stirring. 3 ·6H 2 O, to form a homogeneous solution, then add 6-7g of sodium acetate and 1-2g of polyethylene glycol, stir vigorously for 30 minutes, seal it in a stainless steel autoclave with a polytetrafluoroethylene liner, heat it to 200°C and keep it at a constant temperature for 8 ~10h, then cooled to room temperature, the obtained product was washed 2~4 times with absolute ethanol, and then dried at 60°C for 6h to obtain Fe 3 o 4 Nano magnetic particles;

[0021] Two, the obtained Fe in step 1 3 o 4 Nano-magnetic particles were added to a 200mL three-necked flask containing 75mL deionized water, stirred ultrasonically and nitrogen gas was introduced for 30 minutes to form a nitrogen atmosphere, then 1mL oleic a...

specific Embodiment approach 2

[0026] Specific embodiment 2: The difference between this embodiment and specific embodiment 1 is that in step 1, 75 mL of ethylene glycol is added to a 100 mL round bottom flask, and 2.36 g of FeCl is added under magnetic stirring. 3 ·6H 2 O, form a homogeneous solution, then add the sodium acetate of 6.3g, the polyethylene glycol of 1.75g. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0027] Embodiment 3: This embodiment differs from Embodiment 1 or Embodiment 2 in that 1.4 g of polyvinylpyrrolidone is added during stirring in Step 3. Other steps and parameters are the same as those in Embodiment 1 or Embodiment 2.

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Abstract

The invention relates to a preparation method of magnetic microspheres. The preparation method of the magnetic micro-spheres is used for solving the problems of large grain size distribution of the magnetic microspheres prepared by the existing method and uneven magnetite distribution in each microsphere. The method comprises the following steps of: 1, preparing Fe3O4 nano magnetic particles; 2, preparing Fe3O4 / oleic acid complex particles; and 3, preparing the magnetic microspheres. According to the invention, the magnetic microspheres are prepared by a new, simple dispersion polymerization method, and the obtained microspheres are of micro-scale and uniform in grain size, and have excellent magnetic response and redispersibility. Besides, the Fe3O4 magnetic particles are narrow in grain size distribution which is about 200 nm, and have high saturation magnetization.

Description

technical field [0001] The invention relates to a preparation method of magnetic microspheres. Background technique [0002] In recent years, magnetic microspheres, as a new type of functional material, have attracted widespread attention because of their unique superparamagnetic properties, which enable easy and rapid separation. This characteristic is applied in increasingly diverse fields of biomedicine and bioengineering, including purification of proteins, viruses and nucleic acids, cell separation, immobilized enzymes and targeted drugs, etc. The labeling and separation of cells is one of the earliest applications of magnetic microspheres. Immobilizing free enzymes on magnetic carriers has many advantages, such as improved thermal stability and operational stability, good reproducibility, high use efficiency, and can be used in an external magnetic field. Rapid separation under action. Magnetic separation technology provides a high-throughput method for processing la...

Claims

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Application Information

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IPC IPC(8): B01J13/14
Inventor 孙立国耿文浩赵冬梅汪成
Owner HEILONGJIANG UNIV
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