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Chondroitin sulfate nanofiber non-woven fabric and preparation method and medical purposes thereof

A technology of chondroitin sulfate and nanofibers, which is applied in the field of biomedical tissue engineering materials, can solve problems such as complex processes and troublesome post-processing, and achieve the effects of good air permeability, good uniformity, and accelerated wound healing

Active Publication Date: 2013-07-31
江阴博绯康默生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned patented process is relatively complicated, and the organic solvent trifluoroethanol is introduced, and the post-processing is troublesome

Method used

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  • Chondroitin sulfate nanofiber non-woven fabric and preparation method and medical purposes thereof
  • Chondroitin sulfate nanofiber non-woven fabric and preparation method and medical purposes thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Dissolving chondroitin sulfate with a molecular weight of 50,000 Daltons in deionized water to prepare a solution with a weight percentage of 0.1 wt%, and then fully stirring the solution until it is completely dissolved to obtain a uniform chondroitin sulfate solution;

[0023] (2) Dissolve polyoxyethylene in water to prepare a solution with a weight percentage of 10wt%, and then stir the solution sufficiently so as to completely dissolve to obtain a polyoxyethylene solution.

[0024] (3) Mix the chondroitin sulfate solution and the polyethylene oxide solution, the weight ratio of the chondroitin sulfate and the polyethylene oxide solution is 9:1, and stir thoroughly to obtain a mixed solution;

[0025] (4) Add the mixed solution obtained in step (3) into the syringe pump, adjust the distance from the spinneret to the receiving device to 8cm; start the device for electrospinning, set the spinning voltage to 12kV, and the flow rate of the spinning solution to 0.5mL ...

Embodiment 2

[0027] (1) Dissolving chondroitin sulfate with a molecular weight of 1000 Daltons in deionized water to prepare a solution with a weight percentage of 15 wt%, and then fully stirring the solution until it is completely dissolved to obtain a uniform chondroitin sulfate solution;

[0028] (2) Dissolve polyvinyl alcohol in water to make a solution with a weight percentage of 1wt%, and then stir the solution sufficiently so as to completely dissolve to obtain a polyvinyl alcohol solution.

[0029] (3) Mix chondroitin sulfate solution and polyvinyl alcohol solution, the weight ratio of chondroitin sulfate and polyvinyl alcohol is 1:9, stir well to obtain a mixed solution;

[0030] (4) Add the mixed solution obtained in step (3) into the syringe pump, adjust the distance from the spinneret to the receiving device to 18cm; start the device for electrospinning, set the spinning voltage to 35kV, and the flow rate of the spinning solution to 2.0mL / h, the chondroitin sulfate-based nanof...

Embodiment 3

[0032] (1) Dissolving chondroitin sulfate with a molecular weight of 10,000 Daltons in deionized water to prepare a solution with a weight percentage of 10 wt%, and then fully stirring the solution until it is completely dissolved to obtain a uniform chondroitin sulfate solution;

[0033] (2) Dissolve polyvinylpyrrolidone in water to prepare a solution with a weight percentage of 5wt%, and then stir the solution sufficiently so as to completely dissolve to obtain a polyvinylpyrrolidone solution.

[0034] (3) Mix chondroitin sulfate solution and polyvinylpyrrolidone solution, the weight ratio of chondroitin sulfate and polyvinylpyrrolidone is 3:7, stir well to obtain a mixed solution;

[0035] (4) Preparation of nanofiber dressing: add the mixed solution obtained in step (3) into the syringe pump, adjust the distance from the spinneret to the receiving device to 15cm; start the device for electrospinning, set the spinning voltage to 20kV, and spin The flow rate of the solution ...

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Abstract

The invention relates to chondroitin sulfate nanofiber non-woven fabric and a preparation method and medical purposes thereof. The nanofiber non-woven fabric comprises chondroitin sulfate and synthetic macromolecules, and mainly utilizes the electrospinning technique to process the mixed solution of the chondroitin sulfate and the synthetic macromolecules into the nanofiber; and in the process of electrospinning, the solution performs phase separation, along with volatilization of solvents, so that the nanofiber with a core-shell structure is formed. The obtained chondroitin sulfate nanofiber non-woven fabric has the characteristics of excellent uniformity, high porosity, excellent air permeability and biocompatibility; in the process of the preparation of the chondroitin sulfate nanofiber non-woven fabric, the adopted solution is water, so that no residual organic solution is left; the chondroitin sulfate nanofiber non-woven fabric can be used as a wound dressing and a wound dressing material, has functions of relieving pain, inflammation resistance and accelerating wound healing; and meanwhile, the wound dressing function of the chondroitin sulfate nanofiber non-woven fabric broadens application ranges of the chondroitin sulfate.

Description

technical field [0001] The invention belongs to the field of biomedical tissue engineering materials, and in particular relates to a chondroitin sulfate-based nanofiber nonwoven fabric, a preparation method and a medical application. Background technique [0002] Electrospinning technology is the most effective method for preparing ultra-fine nanofiber nonwoven fabrics. The prepared nanofiber nonwoven fabrics have large specific surface area, high porosity, fineness and uniformity of fibers, and large aspect ratio. advantage. It has important applications in biomedical tissue engineering materials and other fields. [0003] Chondroitin sulfate is a glycosaminoglycan, a polysaccharide composed of repeating disaccharide units linked by D-glucuronic acid and N-acetamidogalactose with β-1,4-glucoside, and exists in large quantities in In animal cartilage, it is mainly extracted from the cartilage of pigs, cattle, chickens and sharks. Chondroitin sulfate, as an important part ...

Claims

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Application Information

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IPC IPC(8): D04H1/4382D04H1/728A61L15/28A61L15/26A61L15/24A61L15/44
Inventor 王克敏俞强
Owner 江阴博绯康默生物医药有限公司
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