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Use of PDLLLA (Poly Dl Lactic Acid)-PEG (Polyethylene Glycol)-PDLLA triblock copolymer in preparing medical anti-adhesion material

A copolymer and triblock technology, used in medical science, surgery, etc., can solve the problems of insignificant phase transition behavior of sol-gel, insufficient solubility of hydrogel, limited application prospects, etc. control, outstanding comprehensive performance, and wide application prospects

Active Publication Date: 2015-03-04
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The use of PEG-PCL-PEG that has been used before is also limited because it needs to use certain toxic cross-linking agents such as HDI, IPDI, and MDI.
In the Chinese patent application document with the application number 201010133541.3, the MPEG-PLLA hydrogel was announced, but the solubility of the hydrogel in water is not good enough, and its sol-gel phase transition behavior is not obvious. Although the material synthesis method is simple, However, the process of preparing MPEG-PLLA into a hydrogel is relatively complicated, so its application prospects are greatly limited.

Method used

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  • Use of PDLLLA (Poly Dl Lactic Acid)-PEG (Polyethylene Glycol)-PDLLA triblock copolymer in preparing medical anti-adhesion material
  • Use of PDLLLA (Poly Dl Lactic Acid)-PEG (Polyethylene Glycol)-PDLLA triblock copolymer in preparing medical anti-adhesion material
  • Use of PDLLLA (Poly Dl Lactic Acid)-PEG (Polyethylene Glycol)-PDLLA triblock copolymer in preparing medical anti-adhesion material

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Synthesis and verification of embodiment 1 copolymer

[0040] 1. Synthesis of PDLLA-PEG-PDLLA Copolymer

[0041] The brief synthetic route of PDLLA-PEG-PDLLA copolymer of the present invention is as follows:

[0042]

[0043] Among them, the molecular weight of the PEG segment is 1000 Daltons and 1500 Daltons respectively. By controlling the molar ratio of PEG and DL-LA, a series of PDLLA-PEG-PDLLA copolymers are synthesized. The obtained copolymer materials are listed in the table 1 in.

[0044] According to the synthesis route, a certain amount of polyethylene glycol (PEG) and lactide (PDLLA) were added to a two-necked flask equipped with a stirrer, and stannous octoate was used as a catalyst. The product is obtained after reacting for 8-18 hours, cooled to room temperature, dissolved in ethanol and precipitated in n-pentane, washed three times with n-pentane, and then dried in a vacuum oven.

[0045] According to the method described above, L 800 -E 1000 -L 80...

Embodiment 2

[0053] The preparation method of embodiment 2 polymer aqueous solution

[0054] Since the principle of each PDLLA-PEG-PDLLA tri-block copolymer to make a hydrogel is the same and the conditions are very similar, the following copolymer is taken as an example. The copolymer is dissolved in physiological saline to obtain a copolymer aqueous solution with a concentration of 10-50wt%, preferably 15-40wt%, and then the temperature reaches the phase transition temperature to form a gel in the solution to obtain a medical anti-adhesion material.

[0055] L 1300 -E 1500 -L 1300 , L 1500 -E 1500 -L 1500 , L 1700 -E 1500 -L 1700 Copolymer: Put the weighed copolymer in a certain volume of physiological saline, and stir it at room temperature for 4-5 hours to form a transparent and clear solution, which is ready for use.

[0056] L 800 -E 1000 -L 800 , L 1000 -E 1000 -L 1000 , L 1200 -E 1000 -L 1200 Copolymer: Place the weighed copolymer in a certain volume of physiologi...

Embodiment 3

[0061] The temperature sensitivity characterization of embodiment 3 copolymer aqueous solution

[0062] (1) The apparent state of the polymer aqueous solution at different temperatures is shown in figure 1 and figure 2 , figure 1 for L 1500 -E 1500 -L 1500 (35%), it can be seen that the polymer aqueous solution is a colorless transparent gel state at 37 ° C, and is a solution state at 25 ° C; figure 2 for L 1000 -E 1000 -L 1000 (35%), it can be seen that the polymer aqueous solution is in the state of white gel at 37°C and in the state of solution at 4°C.

[0063] The difference between the two materials is mainly shown in the method of preservation and use. L1000-E1000-1000 is in gel state at room temperature; while 1500-E1500-L1500 is still in sol state at room temperature. It will be more convenient to use L1500-E1500-L1500 in industrial production.

[0064] (2) Phase transition temperature of different concentrations of copolymer

[0065] In order to understa...

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Abstract

The invention relates to the field of medical high polymer materials and in particular relates to a use of a PDLLA (Poly Dl Lactic Acid)-PEG (Polyethylene Glycol)-PDLLA triblock copolymer in a preparing medical anti-adhesion material. The invention aims to provide a novel choice with lower cost and better effect for the medical anti-adhesion material. The technical scheme of the invention is about a novel use of the PDLLA-PEG-PDLLA triblock copolymer in preparing the medical anti-adhesion material. The invention further provides a medical anti-adhesion material. The invention further provides a method for preparing the medical anti-adhesion material. The invention provides the novel choice for the field that needs using the medical anti-adhesion material, and therefore, the application prospect is extensive.

Description

technical field [0001] The invention relates to the field of medical polymer materials, in particular to the use of a PDLLA-PEG-PDLLA triblock copolymer in preparing medical anti-adhesion materials. Background technique [0002] Postoperative adhesions are common clinical problems after abdominal, gynecological, and cardiac surgery, and are the main cause of postoperative complications such as intestinal obstruction, infertility, and pain. For example, adhesive intestinal obstruction accounted for 60% of intestinal obstruction in the United States in 2004, especially postoperative adhesive intestinal obstruction after pelvic surgery such as obstetrics and gynecology, appendectomy, and colorectal surgery. In recent years, it has become a new trend in the world to prevent postoperative adhesions by implanting isolation materials in the parts prone to postoperative adhesions. However, since postoperative adhesion is a problem that has not been solved for a long time in the fie...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61L31/16
Inventor 钱志勇魏于全
Owner SICHUAN UNIV