Preparation method of degradable lacrimal passage bracket with shape memory function

A technology of lacrimal duct and memory, applied in the preparation of lacrimal duct stents, the preparation of degradable lacrimal duct stents with shape memory function, and the preparation of degradable lacrimal duct stent materials, which can solve the problems of increasing drainage space and achieve easy Implantation, effect of small diameter

Inactive Publication Date: 2013-08-21
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On this basis, some scholars have developed other plastic stents. For example, the Ophthalmology Department of the Second Xiangya Hospital of Central South University implanted a mushroom-shaped nasolacrimal duct stent made of polyurethane to treat the nasolacrimal duct. Blockage, because the drainage lumen of the stent is large, it can support the nasolacrimal duct that has been narrowed or blocked, and keep the nasolacrimal duct unobstructed, and its top is in the shape of a shrunken mushroom, which can be used to fix the drainage tube and strengthen it after the stent is implanted. The role of large drainage space; the operation does not require skin incision and nasal bone window, the operation method is simple and the time is short, it is a traumatic treatment method, but the treatment needs to be performed under X-ray fluoroscopy

Method used

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  • Preparation method of degradable lacrimal passage bracket with shape memory function
  • Preparation method of degradable lacrimal passage bracket with shape memory function
  • Preparation method of degradable lacrimal passage bracket with shape memory function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Using L-lactic acid and 1,4-butanediol as raw materials, the molar ratio of L-lactic acid and 1,4-butanediol is 3:4, after dehydration treatment, adding catalyst stannous octoate (0.8 wt%), Polymerization was carried out for 18 hours at 160° C. and a pressure of 60 Pa. After the reaction, tetrahydrofuran was added to dissolve, then methanol was added to precipitate and purify the product, and vacuum-dried to obtain a white powdery copolymer with a glass transition temperature of about 31 °C and a weight-average molecular weight of about 15,000. Add chain extender diphenylmethane diisocyanate (MDI) in the obtained white powdery copolymer, the molar ratio of chain extender and copolymer is 1:1, add 0.01 wt% chain extension catalyst bis(dodecyl sulfide base) dibutyltin, N 2 Melt chain extension under protection, the reaction temperature is 170 ℃, the time is 50 minutes, and the pressure is 60 Pa. After the reaction is completed, tetrahydrofuran is added to dissolve, then ...

Embodiment 2

[0039] Using L-lactic acid and 1,4-butanediol as raw materials, the molar ratio of L-lactic acid and 1,4-butanediol is 3:4, after dehydration treatment, adding catalyst stannous octoate (0.6 wt%), Polymerization was carried out at 160° C. and a pressure of 60 Pa for 18 hours. After the reaction, tetrahydrofuran was added to dissolve, then methanol was added to precipitate and purify the product, and vacuum-dried to obtain a white powdery copolymer with a glass transition temperature of about 32 °C and a weight-average molecular weight of about 20,000. The chain extender added in the obtained white powdery copolymer is diphenylmethane diisocyanate (MDI), the molar ratio of the chain extender to the copolymer is 1:1, and 0.01 wt% of the chain extender bis(dodecane) is added Sulfuryl) Dibutyltin, N 2 Melt chain extension under protection, the reaction temperature is 170 ℃, the time is 50 minutes, and the pressure is 60 Pa. After the reaction is completed, tetrahydrofuran is adde...

Embodiment 3

[0041] Using L-lactic acid and 1,4-butanediol as raw materials, the molar ratio of L-lactic acid and 1,4-butanediol is 1:1, after dehydration treatment, adding catalyst stannous octoate (0.5 wt%), Polymerization was carried out for 16 hours at 150 °C and a pressure of 50 Pa. After the reaction, tetrahydrofuran was added to dissolve, then ethanol was added to precipitate and purify the product, and vacuum-dried to obtain a white powdery copolymer with a glass transition temperature of about 31 °C and a weight-average molecular weight of about 25,000. In the obtained white powdery copolymer, adding chain extender is hexamethylene diisocyanate (HDI), the mol ratio of chain extender and copolymer is 1:1, adding 0.01 wt% chain extender bis(dodecane Sulfuryl) Dibutyltin, N 2 Melt chain extension under protection, the reaction temperature is 170 ° C, the time is 50 minutes, and the pressure is 60 Pa. After the reaction is completed, tetrahydrofuran is added to dissolve, then ethanol...

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Abstract

The invention relates to a preparation method of a degradable lacrimal passage bracket with a shape memory function. The method comprises the following steps: directly synthesizing a degradable polymer with low weight-average molecular weight by a copolycondensation method with lactic acid, dihydric alcohol or lactic acid, glycollic acid and caprolactone as monomers or by a ring-opening polymerization of lactide and dihydric alcohol or lactide, glycolide and caprolactone; expanding chains; adding nanometer SiO2; melting and co-extruding to prepare a degradable nanometer compound material; extruding and forming to prepare a cylindrical tube of which the inner diameter is 0.4-0.6mm, the outer diameter is 0.8-1.2 mm and the length is 55-65mm; stretching the tube to be a long and thin tube of which the inner diameter is 0.2-0.4mm, the outer diameter is 0.5-0.9mm and the length is 75-85mm at a temperature higher than glass-transition temperature; and cooling and storing to obtain the required product. The lacrimal passage bracket can be used for treating obstruction of nasolacrimal canal, and when the bracket is implanted into the lacrimal passage, the environmental temperature is higher than the glass-transition temperature, and the bracket deforms and recovers, and the diameter gets thick, so that the lacrimal passage bracket is not easy to fall and is like flexible rubber, and the patient feels comfortable.

Description

technical field [0001] The invention belongs to the field of medical biomaterials, and relates to a preparation method of a degradable lacrimal duct bracket with shape memory function. Specifically, it relates to the preparation of a degradable lacrimal duct stent material with shape memory function and a preparation method of the lacrimal duct stent for treating nasolacrimal duct obstruction. Background technique [0002] Nasolacrimal duct obstruction is often caused by inflammation or trauma, and it can lead to chronic dacryocystitis when combined with infection. At present, the commonly used treatment method is nasal dacryocystorostomy, which has a high success rate, but the operation is more complicated, the operation time is longer, and bleeding is easy during the operation. Surgery is contraindicated and surgery is not possible, and the anastomotic stoma is blocked after operation, which makes it difficult to treat again. Indwelling silicone tubes through the lacrima...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L67/04C08K9/06C08K9/04C08K3/36C08G63/06C08G63/08C08G63/78A61L31/06A61L31/02A61L31/14
Inventor 顾书英刘玲玲
Owner TONGJI UNIV
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