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Fluorescent silver nanocluster as well as preparation method and application thereof

A silver nanocluster and fluorescence technology, applied in nanotechnology, nanooptics, nanotechnology and other directions, can solve the problems of long preparation process, complex preparation method, complicated operation, etc., and achieve simple and easy preparation method, easy popularization and application, The effect of high light stability

Active Publication Date: 2014-08-20
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the raw materials used in this method are not common, and the preparation method is more complicated.
Later, the synthetic method using DNA, polypeptide and other biomacromolecules as templates was developed (W.W.Guo, J.P.Yuan, Q.Z.Dong, E.K.Wang, J.Am.Chem.Soc, 2010, 132, 932-934), and reverse glue Beam or microemulsion synthesis method (CN200710168372.5) also all has the defects of expensive raw materials, long preparation process, complex operation and many impurities
Although metal nanoclusters with good luminescence performance can be synthesized by using ultraviolet light irradiation method or microwave method developed in recent years, due to the low yield, special equipment is required, which limits its application and promotion.
The other is the commonly used metal salt liquid phase reduction method (CN201010586429.5), its synthesis method is relatively simple, but it is unavoidable to use some biologically toxic reducing agents (such as sodium borohydride)

Method used

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  • Fluorescent silver nanocluster as well as preparation method and application thereof
  • Fluorescent silver nanocluster as well as preparation method and application thereof
  • Fluorescent silver nanocluster as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1. Preparation of fluorescent silver nanoclusters

[0031] (1). Prepare silver nitrate aqueous solution and polymethacrylic acid aqueous solution respectively, wherein the concentration of silver nitrate in the silver nitrate aqueous solution is 8.3×10 -3 mole / liter; the concentration of polymethacrylic acid in polymethacrylic acid aqueous solution is 2.6×10 -3 Mo / L.

[0032] (2). The silver nitrate aqueous solution prepared in step (1) is mixed with the polymethacrylic acid aqueous solution, so that the concentration of the silver nitrate in the mixed solution is 6.4×10 -3 mole / liter; the concentration of polymethacrylic acid is 3.2×10 -4 Mo / L. Stir at 70°C for 8 hours to obtain an aqueous solution of fluorescent silver nanoclusters, see figure 1 , the average particle size of fluorescent silver nanoclusters is 1.7nm. The wavelength of fluorescence emitted under the excitation of light with a wavelength of 510nm is 610nm, see figure 2 .

[0033] 2. Detection o...

Embodiment 2

[0036] 1. Preparation of fluorescent silver nanoclusters

[0037](1). Prepare silver nitrate aqueous solution and polymethacrylic acid aqueous solution respectively, wherein the concentration of silver nitrate in the silver nitrate aqueous solution is 8×10 -2 mole / liter; the concentration of polymethacrylic acid in polymethacrylic acid aqueous solution is 3×10 -2 Mo / L.

[0038] (2). The silver nitrate aqueous solution prepared in step (1) is mixed with the polymethacrylic acid aqueous solution, so that the concentration of the silver nitrate in the mixed solution is 6.4×10 -2 mole / liter; the concentration of polymethacrylic acid is 6×10 -3 Mo / L. Stirring at 95° C. for 2 hours to obtain an aqueous solution of fluorescent silver nanoclusters, the average particle size of the fluorescent silver nanoclusters is 1.8 nm. The wavelength of the emitted fluorescence is 610nm under the excitation of light with a wavelength of 510nm.

[0039] 2. Selective detection of α-L-fucosidase...

Embodiment 3

[0042] 1. Preparation of fluorescent silver nanoclusters

[0043] (1). Prepare silver acetate aqueous solution and polymethacrylic acid aqueous solution respectively, wherein the concentration of silver acetate in the silver acetate aqueous solution is 3 * 10 -4 mole / liter; the concentration of polymethacrylic acid in polymethacrylic acid aqueous solution is 4.7×10 -5 Mo / L.

[0044] (2). The silver acetate aqueous solution prepared in step (1) is mixed with the polymethacrylic acid aqueous solution, so that the concentration of silver acetate in the mixed solution is 2.5 × 10 -4 mole / liter; the concentration of polymethacrylic acid is 8×10 -6 Mo / L. Stirring at 60° C. for 5 hours, an aqueous solution of fluorescent silver nanoclusters was obtained, and the average particle size of the fluorescent silver nanoclusters was 1.6 nm. The wavelength of the emitted fluorescence is 610nm under the excitation of light with a wavelength of 510nm. The fluorescence intensity emitted by...

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Abstract

The invention belongs to the technical fields of preparation and application of metal optical function nano materials and in particular relates to a fluorescent silver nanocluster as well as a simple preparation method and application thereof. The fluorescent silver nanocluster is synthesized by reacting soluble silver salt with a stabilizer, wherein the fluorescent silver nanocluster has the mean particle size of more than 1.5nm and less than 2nm; the fluorescence emitted by the fluorescent silver nanocluster has the wavelength of 610nm under excitation of light with the wavelength of 510nm; the emitted fluorescence has high illumination stability. The method is readily available in raw materials, simple in process, convenient to operate, low in biotoxicity and easy to popularize and apply. The synthesized fluorescent silver nanocluster can be applied to the fields of optical imaging, biological markers, biological or chemical sensors and the like, and especially can be used for qualitative and quantitative detection on the activity of alpha-L-fucosidase.

Description

technical field [0001] The invention belongs to the technical field of preparation and application of metallic photofunctional nanomaterials, and in particular relates to a fluorescent silver nanocluster and its preparation method and application. Background technique [0002] Metal nanoclusters generally refer to particles containing a few to dozens of atoms with a particle size of less than 2 nanometers. At this time, the particle size of the nanocluster reaches the Fermi wavelength range (about 0.7nm), and the material exhibits a series of peculiar optical, electrical and chemical properties. For example, at this nanoscale, metal nanoclusters have excellent fluorescent properties due to energy level splitting into discrete energy levels. These metal nanoclusters have many properties superior to traditional fluorescent dyes, such as small size, strong photostability, and large Stokes shift, etc., which are expected to be applied in fluorescence imaging, single-molecule sp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/58B22F9/24B82Y40/00B82Y20/00G01N21/64
Inventor 唐芳琼任湘菱陈真真
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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