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Hydroxyapatite/biodegradable polyester composite material and preparation method thereof

A technology for biodegrading polyester and hydroxyapatite, which is applied in the interdisciplinary field of material science and biomedicine, to achieve excellent biocompatibility, bioactivity and good application prospects

Active Publication Date: 2013-09-25
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, looking at the current research progress on the preparation of composite materials by in situ polymerization, it can be found that further modification of this composite material to control the distribution of biologically active hydroxyapatite on the surface and interface of the polymer has rarely been reported.

Method used

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  • Hydroxyapatite/biodegradable polyester composite material and preparation method thereof
  • Hydroxyapatite/biodegradable polyester composite material and preparation method thereof
  • Hydroxyapatite/biodegradable polyester composite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1, in-situ polymerization prepares PDLLA / HA nanocomposite material

[0033] HA (hydroxyapatite) nanoparticles (with a particle diameter of about 50-200 nm) were dried in a vacuum oven at 100° C. for 2 days before the reaction.

[0034] Under the protection of anhydrous, oxygen and argon, 1 g of dried HA nanoparticles was pre-dispersed in distilled toluene, and then 3 g of D, L-LA monomer and 43 μL of stannous octoate catalyst (molar concentration of 0.982 mol / L), add again distilled toluene 20ml (in this system, HA accounts for D, and the mass percent of L-LA monomer is 33.3%, stannous octoate accounts for D, and the mass percent of L-LA monomer is 0.57%, Magnetic stirring, the reaction temperature is 110°C, and the reaction time is 48 hours; after the reaction, the product is repeatedly dissolved with dichloromethane, and the product is precipitated with ice methanol; after multiple washings, the product is vacuum-dried to obtain the PDLLA / HA nanocomposite ...

Embodiment 2

[0035] Embodiment 2, in-situ polymerization prepares PDLLA / HA nanocomposite material

[0036] HA (hydroxyapatite) nanoparticles (with a particle diameter of about 50-200 nm) were dried in a vacuum oven at 100° C. for 2 days before the reaction.

[0037]Under the protection of anhydrous, oxygen and argon, 1 g of dried HA nanoparticles was pre-dispersed in distilled toluene, and then 3 g of D, L-LA monomer and 108 μL of stannous octoate catalyst (molar concentration of 0.982 mol / L), add again distilled toluene 20ml (in this system, HA accounts for D, and the mass percentage of L-LA monomer is 33.3%, stannous octoate accounts for D, and the mass percentage of L-LA monomer is 1.43%, Magnetic stirring, the reaction temperature is 110°C, and the reaction time is 48 hours; after the reaction, the product is repeatedly dissolved with dichloromethane, and the product is precipitated with ice methanol; after multiple washings, the product is vacuum-dried to obtain the PDLLA / HA nanocomp...

Embodiment 3

[0038] Embodiment 3, in-situ polymerization prepares PDLLA / HA nanocomposite material

[0039] HA (hydroxyapatite) nanoparticles (with a particle diameter of about 50-200 nm) were dried in a vacuum oven at 100° C. for 2 days before the reaction.

[0040] Under anhydrous, oxygen-free and argon protection, 0.1 g of dried HA nanoparticles were pre-dispersed in distilled toluene, and then 10 g of D, L-LA monomer and 144 μL of stannous octoate catalyst (molar concentration of 0.982 mol / L), add again distilled toluene 20ml (in this system, HA accounts for D, and the mass percentage of L-LA monomer is 1%, and stannous octoate accounts for D, and the mass percentage of L-LA monomer is 0.57% , magnetic stirring, the reaction temperature is 110°C, and the reaction time is 48 hours; after the reaction, the product is repeatedly dissolved with dichloromethane, and the product is precipitated with ice methanol; after multiple washings, the product is vacuum-dried to obtain the PDLLA / HA nano...

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Abstract

The invention discloses a hydroxylapatite / biodegradable polyester composite material and a preparation method thereof. The preparation method includes the following steps: under conditions of no water, no oxygen, and argon protection, the composite material is obtained by carrying out an in-situ polymerization reaction of hydroxyapatite and an aliphatic cyclic monomer under catalysis of stannous octoate; the aliphatic cyclic monomer is selected form at least one of lactide, epsilon-caprolactone and glycolide; and the composite material provided by the invention comprises hydroxylapatite and a biodegradable polyester. The composite material provided by the invention has the surface enriched with a hydroxylapatite layer having a biological activity, and has an excellent biological compatibility and the biological activity; an biological activity interface can rapidly induce calcium ion deposition in a physiological environment so as to induce nucleation and growth of apatite, and imitates inorganic / organic components of a natural bone matrix in composition; based on the above characteristics, the modified hydroxylapatite / biodegradable polyester composite material is a good support material for repairing bone defects, and has good application prospects in the fields of cell expansion and bone tissue engineering.

Description

technical field [0001] The invention relates to a hydroxyapatite / biodegradable polyester composite material and a preparation method thereof, which belong to the cross field of material science and biomedicine. Background technique [0002] The treatment of bone defects is a thorny problem that has plagued the field of clinical medicine for a long time. It has been clinically proven that autologous bone grafting is the best method for treating bone defects, but its wide application is limited due to the problem of its source and the damage to the patient's bone extraction area. Allogeneic bone is easy to obtain, but there are considerable hidden dangers in biological safety, patients may have immune rejection, and there is a risk of virus infection due to implantation of foreign bone materials. Therefore, artificially prepared materials are more and more widely used clinically as hard tissue repair materials. The selection of artificial materials should consider the follow...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/08C08K3/32C08L67/04A61L27/46
Inventor 甘志华杜珂
Owner INST OF CHEM CHINESE ACAD OF SCI
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