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Composite antibacterial gel and preparation method thereof

A compound antibacterial agent and compound antibacterial technology, which is applied in the direction of antibacterial drugs, drug combinations, pharmaceutical formulations, etc., can solve the problems of low grafting rate, easy production of organic solvents, cost and environmental pressure, etc., to achieve simple process and promote wound healing. The effect of healing and promoting wound healing

Inactive Publication Date: 2013-10-23
GUANGDONG TAIBAO MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports on the application of amino acids in antibacterial materials at present. It has been reported in the literature that amino acids are introduced into chitosan by graft copolymerization, but the grafting rate of the products prepared by this method is low, and in the preparation process Easy to generate organic solvents, which puts pressure on both cost and environment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Comparison of antibacterial effects of different antibacterial raw materials acting alone

[0039] Dissolve 1g of chitosan in 100mL of 8% acetic acid solution, add 1g of dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride, 1g of lysine, 1g of arginine , 1g of histidine, 1g of aspartic acid, and 1g of glutamic acid were dissolved in 100 mL of sterile water, and sterile distilled water was used as a blank control, and Escherichia coli and Candida albicans were inhibited by the agar diffusion disc method. Bacteria experiment.

[0040] The antibacterial rate test results to Escherichia coli and Candida albicans are as follows: chitosan 70 and 75%, dimethyl octadecyl [3-(trimethoxysilyl) propyl] ammonium chloride 72% and 78% , lysine 65% and 72%, arginine 62% and 67%, histidine 68% and 69%, aspartic acid 50% and 42%, glutamic acid 39% and 36%.

[0041] It can be seen from the above data that the above raw materials have certain antibacterial effects on Escherichi...

Embodiment 2

[0051] Add 0.2g of chitosan to 100mL of acetic acid solution with a mass concentration of 3%, stir evenly at room temperature until the chitosan is completely dissolved; under stirring, add 0.2g of lysine to the chitosan acetic acid solution, stir Uniformly dissolve it completely; under the same stirring condition, add 0.1g dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride to the above mixed solution, stir to make it dissolve evenly . Dissolve 15g of gelatin in 100mL of pure water, heat and stir at 30°C until dissolved evenly. Add the mixed solution of chitosan, lysine and dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride into the dissolved gelatin solution, stir evenly, then let it stand for cooling to room temperature, the product is obtained, the pH is adjusted to 6.5 with lactic acid solution, and the product is sterilized and packaged.

[0052] The antibacterial properties of the composite gel prepared under the above conditions were tested, and ...

Embodiment 3

[0066] Add 0.9g of chitosan into 100mL of acetic acid solution with a mass concentration of 5%, and stir evenly at room temperature until the chitosan is completely dissolved; It was completely dissolved; under the same stirring condition, 1.5 g of dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride was added to the above mixed solution, and stirred to make it dissolve evenly. Dissolve 15g of gelatin in 100mL of pure water, heat and stir at 40°C until dissolved evenly. Add the mixed solution of chitosan, arginine and dimethyloctadecyl [3-(trimethoxysilyl) propyl] ammonium chloride into the dissolved gelatin solution, stir evenly, then let it stand for cooling to room temperature, adjust the pH to 6 with lactic acid solution to obtain the product, and sterilize and package the product.

[0067] The antibacterial properties of the composite gel prepared under the above conditions were tested, and the test results proved that the antibacterial rates of the composite ge...

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Abstract

The present invention discloses a composite antibacterial gel and a preparation method thereof. The composite antibacterial gel which has highly antibacterial performances is prepared by compositing gelatin, chitosan, amino acid and dimethyl octadecyl[3-(trimethoxysilyl)propyl]ammonium chloride. The composite antibacterial gel can stop bleeding, promote wound healing, has highly antibacterial properties, has a certain effect on treatment of vaginitis (bacterial vaginosis, candida vaginitis, mixed vaginitis, vulvitis) and cervical erosion and other gynecological diseases, and also has the effect of cleaning and nursing female privates, stopping bleeding, killing pain, diminishing inflammation, killing bacteria and promoting wound healing.

Description

technical field [0001] The invention belongs to the field of medical dressing preparations, in particular to an antibacterial gel and a preparation method thereof. Background technique [0002] Hydrogel medical dressing is a new type of medical dressing developed in recent years. It is a swollen polymer with a three-dimensional network structure containing a certain amount of water. It has good water absorption and biocompatibility, and can be closely attached to uneven wounds without adhesion, reducing the chance of bacterial growth and easy to replace. , and can participate in various pharmaceutical ingredients and growth factors to promote wound healing. Compared with traditional dressings, hydrogel can better promote wound healing and relieve patients' pain. It can improve the microenvironment of the wound and inhibit the growth of bacteria. It is especially suitable for common body surface wounds, such as abrasions, scratches, etc. wounds, bedsores and other skin inj...

Claims

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Application Information

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IPC IPC(8): A61K31/722A61K9/06A61P31/04A61P17/02A61P7/04A61P15/02A61P15/00A61L15/28A61L15/20A61L15/32A61L15/44A61K31/4172A61K31/205A61K31/198
Inventor 卢亢陈锦涛韦加娜黄建伟王志鸿
Owner GUANGDONG TAIBAO MEDICAL SCI TECH
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