Preparation method for whitening and repairing lipid nanoparticle emulsion

A lipid nanoparticle and whitening technology, which is applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of decreased content of active substances, impact on promotion and use, and deterioration of finished product appearance, so as to increase shelf life and scale Industrial production is convenient, and the effect of whitening and repairing is remarkable

Active Publication Date: 2013-11-20
PROYA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The bark extract of flower palm and dragon's blood extract are less stable in cosmetic formulations, and are easily oxidized, resulting in a rapid decrease in content; the problem with Indian gooseberry extract is that it will change color when it encounters divalent metal ions
The color of the flower palm bark extract will change from colorless to dark yellow during the oxidation process, t

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0028] Example one:

[0029] A preparation method of whitening and repairing lipid nanoparticle emulsion adopts the following steps:

[0030] A. According to the mass ratio of 2:1:1:1:1, weigh out 11.666g glycerol stearate, 5.833g sapling sapling oil, 5.833g sapling sapling oil, 5.833g garcinia cambogia seed oil , 5.833g Indian hematoma fruit resin, the mixture is heated in a beaker at 75°C in a water bath to obtain a liquid oil phase; the melting point of the mixture is 48°C;

[0031] B. According to the ratio of 2.67:1.67:1, weigh out 4.0g palm tree bark extract, 2.5g Indian gooseberry extract, 1.5g dragon blood extract, add them to the above liquid oil phase, and control the stirrer Rotate speed is 500rpm, stir for 5 minutes, stir and mix evenly, keep at 75℃;

[0032] C. Weigh 21.0g of emulsifier (including hydrogenated lecithin (trade name SOYA SPL 75H) 10.5g, sucrose fatty acid ester (trade name SURFHOPE SE COSME C1815) 10.5g) and 136.0g at a mass ratio of 0.15:1 Distilled wat...

Example Embodiment

[0035] Embodiment two:

[0036] A preparation method of whitening and repairing lipid nanoparticle emulsion adopts the following steps:

[0037] A. According to the mass ratio of 1.5:0.5:1, weigh 12g of glyceryl stearate, 4g of winged salamander, and 8g of Indian hematoma fruit fat and mix them in a beaker. Heat in a water bath at 85°C to obtain a liquid oil phase. ; The melting point of the mixture is 56°C;

[0038] B. Weigh out 3.0g palm tree bark extract, 1.0g Indian gooseberry extract, 0.5g dragon blood extract in a ratio of 6:2:1, add them to the above liquid oil phase, and control the stirrer Rotate speed is 500rpm, stir for 5 minutes, stir and mix evenly, keep at 85℃;

[0039] C. Weigh 28.5g of emulsifier (including hydrogenated lecithin (trade name: PHOSPHOLIPON 90 H) 9.5g, sucrose fatty acid ester (trade name: SURFHOPE SE COSME C1616) 19g) and 143.0 at a mass ratio of 0.2:1 g Distilled water, put it in a beaker, heat to 85°C, stir evenly to obtain a liquid water phase;

[...

Example Embodiment

[0042] Embodiment three:

[0043] A preparation method of whitening and repairing lipid nanoparticle emulsion adopts the following steps:

[0044] A. According to the mass ratio of 4:2:1:1, weigh 20g glycerol stearate, 10g salamantha seed fat, 5g Indian garcinia cambogia seed fat, 5g Indian hematoma fruit fat and mix them in a beaker, 85 Heat in a water bath at ℃ to obtain a liquid oil phase; the melting point of the mixture is 63℃;

[0045] B. According to the mass ratio of 5.3:4:1, weigh out 8.0g palm tree bark extract, 6.0g Indian gooseberry extract, 1.5g dragon blood extract, and add them to the above liquid oil phase , Control the speed of the stirrer to 500rpm, stir for 5 minutes, stir and mix evenly, and keep it at 80℃;

[0046] C. Weigh out 28.9g of emulsifier (including hydrogenated lecithin (trade name PHOSPHOLIPON 90 H) 7.22 g, hydrogenated lecithin (trade name SOYA SPL 75H) 7.22 g, and sucrose fat at a mass ratio of 0.25:1 Acid ester (trade name SURFHOPE SE COSME C1815)...

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Abstract

The invention relates to a preparation method for a whitening and repairing lipid nanoparticle emulsion. The preparation method comprises the following steps: A, weighing a lipid material and heating the lipid material to a temperature of 75 to 85 DEG C so as to obtain a liquid oil phase; B, weighing an Ormosia henryi bark extract, an Indian currant extract and a dragon's blood extract in proportion so as to obtain whitening and repairing active matters; C, uniformly mixing the whitening and repairing active matters with the lipid material, then heating to a temperature of 75 to 85 DEG C and carrying out uniform stirring so as to obtain a liquid oil phase; D, weighing a mixture of hydrogenated lecithin and sucrose fatty acid ester so as to form a mixed emulsifier; E, weighing and mixing the mixed emulsifier and distilled water and heating to a temperature of 75 to 85 DEG C so as to obtain a liquid water phase; and F, uniformly mixing the liquid oil phase and the liquid water phase with stirring so as to obtain mixed liquor, carrying out cyclic homogenization 10 to 15 times at a pressure of 70 to 150 MPa and a temperature of 75 to 90 DEG C and cooling to room temperature so as to obtain the whitening and repairing lipid nanoparticle emulsion. The invention has the advantage that the three active matters consisting of the Ormosia henryi bark extract, the Indian currant extract and the dragon's blood extract can be loaded at the same time.

Description

technical field [0001] The invention relates to the technical field of lipid nanoparticle preparation, in particular to a method for preparing a whitening and repairing lipid nanoparticle emulsion. Background technique [0002] PTEROCARPUS MARSUPIUM bark extract (Chinese INCI name: PTEROCARPUS MARSUPIUM bark extract) is commonly used in the ancient Indian Ayurvedic medical system to treat cardiovascular and diabetes. It is now clear that pterostilbene (Pterostilbene) of the bark extract of the flowering palm tree is its key active ingredient. The producer of the bark extract used in the present invention is American SABINSA company, white or off-white crystalline powder, trade name is PTEROWHITE, contains pterostilbene of 90% purity. Pterostilbene can achieve whitening effect through the induction of PPARα, at the same time, it can inhibit the lipid peroxidation of cell membrane, and it can also exert anti-inflammatory effect by inhibiting COX-2. The bark extract of the fl...

Claims

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Application Information

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IPC IPC(8): A61K8/97A61K8/92A61K8/06A61Q19/02A61Q19/00
Inventor 蒋丽刚毕永贤陆海英
Owner PROYA COSMETICS
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