Preparation method for whitening and repairing lipid nanoparticle emulsion

Abstract

The invention relates to a preparation method for a whitening and repairing lipid nanoparticle emulsion. The preparation method comprises the following steps: A, weighing a lipid material and heating the lipid material to a temperature of 75 to 85 DEG C so as to obtain a liquid oil phase; B, weighing an Ormosia henryi bark extract, an Indian currant extract and a dragon's blood extract in proportion so as to obtain whitening and repairing active matters; C, uniformly mixing the whitening and repairing active matters with the lipid material, then heating to a temperature of 75 to 85 DEG C and carrying out uniform stirring so as to obtain a liquid oil phase; D, weighing a mixture of hydrogenated lecithin and sucrose fatty acid ester so as to form a mixed emulsifier; E, weighing and mixing the mixed emulsifier and distilled water and heating to a temperature of 75 to 85 DEG C so as to obtain a liquid water phase; and F, uniformly mixing the liquid oil phase and the liquid water phase with stirring so as to obtain mixed liquor, carrying out cyclic homogenization 10 to 15 times at a pressure of 70 to 150 MPa and a temperature of 75 to 90 DEG C and cooling to room temperature so as to obtain the whitening and repairing lipid nanoparticle emulsion. The invention has the advantage that the three active matters consisting of the Ormosia henryi bark extract, the Indian currant extract and the dragon's blood extract can be loaded at the same time.

Description

technical field [0001] The invention relates to the technical field of lipid nanoparticle preparation, in particular to a method for preparing a whitening and repairing lipid nanoparticle emulsion. Background technique [0002] PTEROCARPUS MARSUPIUM bark extract (Chinese INCI name: PTEROCARPUS MARSUPIUM bark extract) is commonly used in the ancient Indian Ayurvedic medical system to treat cardiovascular and diabetes. It is now clear that pterostilbene (Pterostilbene) of the bark extract of the flowering palm tree is its key active ingredient. The producer of the bark extract used in the present invention is American SABINSA company, white or off-white crystalline powder, trade name is PTEROWHITE, contains pterostilbene of 90% purity. Pterostilbene can achieve whitening effect through the induction of PPARα, at the same time, it can inhibit the lipid peroxidation of cell membrane, and it can also exert anti-inflammatory effect by inhibiting COX-2. The bark extract of the fl...

AI Technical Summary

Problems solved by technology

[0005] The bark extract of flower palm and dragon's blood extract are less stable in cosmetic formulations, and are easily oxidized, resulting in a rapid decrease in content; the problem with Indian gooseberry extract is that it will change color when it encounters divalent metal ions

The color of the flower palm bark extract will change from colorless to dark yellow during the oxidation process, the dragon's blood extract will change from golden yellow to dark brown, and the Indian gooseberry extract will turn gray when it encounters divalent metal ions. The change directly leads to a decrease in the content of the active substance, and the change in the color of the active substance will lead to the deterioration of the appearance of the final product, which affects the promotion and use