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Method for preparation of hydroxyapatite nanorod and nanowire by hydrothermal process

A hydroxyapatite and hydrothermal technology, applied in chemical instruments and methods, nanotechnology, nanotechnology, etc., can solve problems such as environmental pollution, increase process complexity and production cost, and achieve environmentally friendly and excellent protein adsorption. and release performance, shape controllable effect

Active Publication Date: 2013-11-27
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The surfactants and organic or inorganic templates added in this method need to be removed in subsequent processing, thus increasing the complexity of the process and production costs, and causing environmental pollution

Method used

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  • Method for preparation of hydroxyapatite nanorod and nanowire by hydrothermal process
  • Method for preparation of hydroxyapatite nanorod and nanowire by hydrothermal process
  • Method for preparation of hydroxyapatite nanorod and nanowire by hydrothermal process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Add 10 mL of 0.1 M calcium chloride aqueous solution dropwise to 20 mL of 15.5 mg / mL riboflavin sodium phosphate aqueous solution at a rate of 10 mL / min, adjust the pH of the mixture to 9 with 1 M sodium hydroxide, and stir for 5 minutes. The mixed solution was placed in a hydrothermal reaction kettle, the hydrothermal heating temperature was 180°C, and the reaction was carried out for 24 hours. After the reaction, the precipitate was collected by centrifugation, washed with water, and dried in air at 60°C to obtain hydroxyapatite nanorods.

[0034] The samples were characterized by SEM and TEM, such as figure 1 and 2 shown. It can be seen from the figure that the shape of the prepared sample is a nanorod, the length of the nanorod is about 50 nm to 200 nm, and the width is about 20 nm to 50 nm. The obtained hydroxyapatite nanorods have the characteristics of good dispersion, uniform size and the like.

Embodiment 2

[0036] Add 10 mL of 0.1 M calcium chloride aqueous solution dropwise to 20 mL of 15.5 mg / mL riboflavin sodium phosphate aqueous solution at a rate of 15 mL / min, adjust the pH value of the mixture to 5 with dilute hydrochloric acid, stir for 5 minutes, and The mixed solution was placed in a hydrothermal reaction kettle, the hydrothermal heating temperature was 180°C, and the reaction was carried out for 24 hours. After the reaction, the precipitate was collected by centrifugation, washed with water, and dried in air at 60°C to obtain hydroxyapatite nanowires.

[0037] The samples were characterized by SEM and TEM, such as image 3 and 4 shown. It can be seen from the figure that the shape of the prepared sample is nanowire, and the length of the nanowire is several micrometers to tens of micrometers.

Embodiment 3

[0039] The hydroxyapatite nanorods and nanowires obtained in Example 1 and Example 2 were added to an aqueous solution containing bovine hemoglobin, and after shaking for 24 hours at 37°C, the product was centrifuged, washed, and dried to obtain the adsorbed protein hydroxyapatite nanorods / nanowires. The protein-adsorbed hydroxyapatite nanorods / nanowires have good sustained-release performance and pH-controlled release behavior in phosphate buffers with different pH values. Such as Figure 5 As shown, in phosphate buffer at pH 4.5, the release of HA nanorods and nanowires adsorbed bovine hemoglobin reached equilibrium in 12 hours, and the release amounts were 7% and 12%, respectively; however, in phosphate buffer at pH 7.4 The hydroxyapatite nanorods and nanowires adsorbed bovine hemoglobin in the buffer solution reached equilibrium after slow release for 142 hours, and the equilibrium release amounts were 44% and 36%, respectively. This is because bovine hemoglobin is a neu...

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Abstract

The invention relates to a method for preparation of a hydroxyapatite nanorod and a nanowire by a hydrothermal process. The method includes: adding a water soluble calcium salt solution into a riboflavin sodium phosphate solution at a rate of 3-50ml / min, adjusting the pH of the obtained mixed solution to 8-12 or 4-6, then leaving the solution to undergo a hydrothermal reaction at 100-200DEG C for 1-48h, carrying out separation, washing and drying the precipitate, thus obtaining the hydroxyapatite nanorod and nanowire.

Description

technical field [0001] The invention relates to a method for preparing hydroxyapatite nanorods and nanowires by a hydrothermal method. It specifically relates to a method for preparing hydroxyapatite nanorods and nanowires by using organic biomolecule riboflavin sodium phosphate as a phosphorus source and inorganic calcium salt as a calcium source through a hydrothermal method, which belongs to the field of biomaterial preparation and drug sustained release . Background technique [0002] As the main inorganic component of hard tissues in vertebrates, hydroxyapatite has excellent biocompatibility and biodegradability, as well as the advantages of natural non-toxicity and not easy to be phagocytized by immune cells. Therefore, hydroxyapatite material is an ideal Inorganic biomaterials. Nanostructured hydroxyapatite materials have high specific surface area and thus high drug loading. Calcium ions on the surface of hydroxyapatite materials have a good complexation effect on...

Claims

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Application Information

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IPC IPC(8): C01B25/32B82Y30/00
Inventor 朱英杰赵新宇陈峰
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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