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Cyclovirobuxine D sublingual tablet as well as preparation method and application thereof

A technology of cyclovir buxus and sublingual tablets, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, pill delivery, etc., can solve problems such as unfavorable industrial production, complex types of auxiliary materials, and cumbersome adding procedures, etc. The effect of less, low production cost and high drug content

Inactive Publication Date: 2013-12-11
CHENGDU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the process of this method is cumbersome, and due to the need for heating, melting, quenching or dissolving a large number of organic solvents and solvent recovery of the solid dispersion carrier during the preparation process, the preparation cost is relatively high; in addition, the disclosed in the application Tablets, the types of excipients are complex, and the addition process is relatively cumbersome, which is not conducive to industrial production

Method used

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  • Cyclovirobuxine D sublingual tablet as well as preparation method and application thereof
  • Cyclovirobuxine D sublingual tablet as well as preparation method and application thereof
  • Cyclovirobuxine D sublingual tablet as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 Preparation of sublingual tablet of the present invention

[0026] 【prescription】

[0027]

[0028] 【Preparation】

[0029] First, mix the drug CVB-D with 2 / 3 of the prescription amount of the disintegrant low-substituted hydroxypropyl cellulose (L-HPC), and then add the filler lactose and microcrystalline cellulose in equal increments, and mix well. Add an appropriate amount of binder (10% starch slurry) to make the prepared soft material "lightly hold into a ball and disperse when pressed", pass through a 20-mesh sieve, and dry the obtained wet granules. After sizing, add the remaining 1 / 3 of the disintegrant, ready to be compressed into tablets. Embodiment 2 Preparation of sublingual tablet of the present invention

Embodiment 2

[0029] First, mix the drug CVB-D with 2 / 3 of the prescription amount of the disintegrant low-substituted hydroxypropyl cellulose (L-HPC), and then add the filler lactose and microcrystalline cellulose in equal increments, and mix well. Add an appropriate amount of binder (10% starch slurry) to make the prepared soft material "lightly hold into a ball and disperse when pressed", pass through a 20-mesh sieve, and dry the obtained wet granules. After sizing, add the remaining 1 / 3 of the disintegrant, ready to be compressed into tablets. Embodiment 2 Preparation of sublingual tablet of the present invention

[0030] 【prescription】

[0031]

[0032] 【Preparation】

[0033] First, mix the drug CVB-D with 2 / 3 of the prescription amount of the disintegrant low-substituted hydroxypropyl cellulose (L-HPC), and then add the filler lactose and microcrystalline cellulose in equal increments, and mix well. Add an appropriate amount of binder (10% starch slurry) to make the prepared so...

Embodiment 3

[0033] First, mix the drug CVB-D with 2 / 3 of the prescription amount of the disintegrant low-substituted hydroxypropyl cellulose (L-HPC), and then add the filler lactose and microcrystalline cellulose in equal increments, and mix well. Add an appropriate amount of binder (10% starch slurry) to make the prepared soft material "lightly hold into a ball and disperse when pressed", pass through a 20-mesh sieve, and dry the obtained wet granules. After sizing, add the remaining 1 / 3 of the disintegrant, ready to be compressed into tablets. Embodiment 3 Preparation of sublingual tablet of the present invention

[0034] 【prescription】

[0035]

[0036]

[0037] 【Preparation】

[0038] First, mix the drug CVB-D with 2 / 3 of the prescription amount of the disintegrant low-substituted hydroxypropyl cellulose (L-HPC), and then add the filler lactose and microcrystalline cellulose in equal increments, and mix well. Add an appropriate amount of binder (10% starch slurry) to make the...

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Abstract

The invention provides a cyclovirobuxine D sublingual tablet which is a preparation prepared from the following raw materials and auxiliary materials in parts by weight: 0.1-0.2 part of cyclovirobuxine D, 4-7 parts of lactose or pregelatinized starch, 3-5 parts of microcrystalline cellulose and 0.3-0.7 part of low-substituted hydroxypropyl cellulose. The invention further provides a preparation method and an application of the sublingual tablet. The sublingual tablet provided by the invention has small categories of auxiliary materials, high drug concentration, high disintegrating speed and excellent permeable membrane absorption, and can be effectively used for sublingual administration; in addition, after the raw materials and the auxiliary materials are mixed, a special dispersion technology is not needed for processing so that a forming process is simple and convenient, the production cost is low, and the industrial production is beneficial.

Description

technical field [0001] The invention relates to a sublingual tablet of cyclovir buxicine D and its preparation method and application. Background technique [0002] Cyclovirobuxine D (CVB-D for short) is a plant active monomer extracted from Buxus microphylla Sieb.et Zucc.var.sinica Rehd.et Wils. Its chemical structure is pregnant The derivative of sterane, the molecular formula is C26H46N2O, which is the first new drug for the treatment of cardiovascular and cerebrovascular diseases in my country. Clinical studies have shown that: Cyclovirubuxin D has three types of antiarrhythmic effects, but no side effects of CVB-D with three types of antiarrhythmic drugs have been observed; it can also eliminate free radicals in the body by inhibiting lipid peroxidation , increase coronary flow, thereby improving myocardial oxygen supply; improve cerebral circulation, and have the effect of protecting neurons; boosting blood pressure has quick onset, obvious curative effect, and long-la...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/57A61P9/06A61P9/10A61P25/00
Inventor 钟玲张仲林张冬梅章雪辉姜小丽陈洋
Owner CHENGDU MEDICAL COLLEGE
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