Production process of hesperidin

A production process and a technology for hesperidin, applied in the field of hesperidin preparation from citrus aurantium, can solve the problems of complex hesperidin process, low waste water discharge, large waste water discharge, etc., and solve the problem of sewage treatment and reduce the waste water volume. , the effect of improving product quality

Inactive Publication Date: 2013-12-25
CHENGDU OKAY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0034] The purpose of the present invention is to overcome the problems of complex extraction process of hesperidin from Fructus Citrus Citrus Fructus, large waste water discharge and high cost in the prior art, and provide a production process of hesperidin. The process is simple and the purity of the extracted hesperidin is High, and can take into account the extraction of other active ingredients, less waste water discharge, low cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Get the dried citrus aurantium with a particle diameter of 9 mm, crush it to 80% through a 40 mesh sieve with a 1 to 2 mm tile sieve, add 3 times the mass concentration of citrus aurantium weight as 88% methanol solution and 1 / 95 citrus aurantium weight The sodium hydroxide is heated up to 65°C, the heating is stopped, and the citrus aurantium filter residue is obtained by circulatory soaking at room temperature for 8 hours, and the filter residue is obtained; the citrus aurantium is then washed with a mixed solvent of 88% methanol and sodium hydroxide that is 0.5 times the weight of the filter residue of the aurantium Filter the residue, filter to obtain filtrate A, fine filter the filtrate A to obtain the filtrate B, add hydrochloric acid to the filtrate B to adjust its pH value to 5-6, let stand for crystallization for 4 hours, filter, collect crystals and hesperidin Mother liquor; the crystals are washed with water until the pH value is 7, and are colorless, dried to...

Embodiment 2

[0056] Get the dried citrus aurantium with a particle diameter of 25mm, grind it to 80% through a 40 mesh sieve with a 1-2 mm tile sieve, add 4 times the mass concentration of citrus aurantium weight and be 90% methanol solution and 1 / 95 citrus aurantium weight The sodium hydroxide is heated up to 65°C, the heating is stopped, and the citrus aurantium filter residue is obtained by circulatory soaking at room temperature for 10 hours, and the filter residue is obtained; the citrus aurantium is washed with a mixed solvent of 88% methanol and sodium hydroxide that is 0.5 times the weight of the filter residue of the aurantium fruit Filter the residue, filter to obtain filtrate A, fine filter the filtrate A to obtain the filtrate B, add hydrochloric acid to the filtrate B to adjust its pH value to 5-6, let stand for crystallization for 4 hours, filter, collect crystals and hesperidin Mother liquor; the crystals are washed with water until the pH value is 7 and colorless, and dried ...

Embodiment 3

[0058] Get the dried citrus aurantium with a particle diameter of 18 mm, grind it to 80% through a 40 mesh sieve with a 1 to 2 mm tile sieve, add 4 times the mass concentration of the citrus aurantium weight and be 89% methanol solution and 1 / 95 citrus aurantium weight The sodium hydroxide is heated up to 65°C, the heating is stopped, and the citrus aurantium filter residue is obtained by circulating soaking at room temperature for 9 hours, and the filter residue is obtained; then the citrus aurantium filter residue is washed with a mixed solvent of 88% methanol and sodium hydroxide, which is 0.5 times the weight of the filter residue of the aurantium fruit Filter the residue, filter to obtain filtrate A, fine filter the filtrate A to obtain the filtrate B, add hydrochloric acid to the filtrate B to adjust its pH value to 5-6, let stand for crystallization for 4 hours, filter, collect crystals and hesperidin Mother liquor; the crystals were washed with water until the pH value ...

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PUM

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Abstract

The invention discloses a production process of hesperidin, and in particular discloses a process for extracting the hesperidin from an immature bitter orange. The production process comprises the steps of (1) grinding the immature bitter orange, and adding a mixed solvent of methyl alcohol and alkali for cyclic soaking, extraction and filtration to obtain immature bitter orange residues; (2) washing the immature bitter orange residues with the mixed solvent of the methyl alcohol and the alkali, performing filtration to obtain filter liquid (A), and performing refined filtration on the obtained filter liquid (A) to obtain filter liquid (B); (3) adding acid into the filter liquid (B) to adjust the pH value to 5-6, and performing standing and crystallization; (4) collecting crystals, and performing washing and drying to obtain the hesperidin. The production process is simple, the extracted hesperidin is high in purity, other effective components can be also extracted, the emission of waste water is low, and the cost is low.

Description

technical field [0001] The invention belongs to the field of plant extraction, and in particular relates to a process for preparing hesperidin by using citrus aurantium fruit. Background technique [0002] Citrus aurantium, recorded in the 2005 edition of the Chinese Pharmacopoeia, page 172, is the dried young fruit of the Rutaceae plant sour orange and its cultivars or sweet orange. It is a commonly used folk Chinese herbal medicine. and other effects. [0003] Hesperidin is widely distributed in nature, and mainly exists in legumes, birch, Lamiaceae, Papilionaceae, and citrus plants. Hesperidin has good biological activity, has anti-lipid oxidation and scavenging oxygen free radicals, anti-inflammatory, anti-virus, anti-bacterial, enhances capillary toughness, shortens bleeding time, and lowers cholesterol. It is clinically used in the cardiovascular system Auxiliary treatment of diseases, can cultivate a variety of drugs to prevent arteriosclerosis and myocardial infarc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08
Inventor 赵卓君
Owner CHENGDU OKAY PHARMA
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