A kind of 4-(3h) quinazolone peroxy copper complex and its synthesis method

A quinazolidone copper peroxide and synthesis method technology, applied in the direction of copper organic compounds, etc., can solve the problems of harmfulness to human body and environment, low catalytic activity, long reaction time, etc.

Inactive Publication Date: 2016-01-20
GUANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Since then, there have been many reports on the use of molybdenum and tungsten peroxo complexes as catalytic oxidation catalysts, but the concentration of hydrogen peroxide used is generally high, the amount is also large, the reaction time is long, the catalytic activity is low, and generally toxic halogenated Hydrocarbons are used as solvents, which are harmful to humans and the environment

Method used

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  • A kind of 4-(3h) quinazolone peroxy copper complex and its synthesis method
  • A kind of 4-(3h) quinazolone peroxy copper complex and its synthesis method
  • A kind of 4-(3h) quinazolone peroxy copper complex and its synthesis method

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Embodiment 1

[0021] The preparation of 4-(3H) quinazolonone peroxycopper complex of the present invention:

[0022] Dissolve (0.0296g, 0.2mmol) 4-(3H)quinazolone and (0.0241g, 0.1mmol) copper nitrate tetrahydrate in 10ml of acetonitrile solvent, and pour the resulting mixed solution into polytetrafluoroethylene for high-pressure hydrothermal reaction In the kettle, under the hydrothermal reaction conditions of 150 and 130 degrees, react for one day respectively, and cool to room temperature. Filter and collect in a beaker to obtain a yellow filtrate. Put the filtrate in the air, 10-20 minutes, yellow crystals precipitated from the mother liquor. 0.0512 g of yellow 4-(3H)quinazolone peroxycopper complex crystals were collected, and the yield was about 66%.

Embodiment 2

[0024] The single crystal X-ray diffraction experiment conditions and results of the complex of the present invention are as follows:

[0025] The single crystal X-ray diffraction experiment was carried out on a Bruker diffractometer, using a Mo target of a graphite monochromator, at a temperature of 293K, a voltage of 50kV, and a current of 80mA to collect independent diffraction points, using SHELXS-97 and SHELXL-97 program packages Carry out structure analysis, hydrogenation and refinement. All non-hydrogen atoms are refined using the full matrix least squares method (Full-matrix least-squares refinement base on F2). All non-hydrogen atoms are subjected to anisotropic refinement. Other details about the crystal The information is listed in Table 1, Table 2 and Table 3.

[0026] Table 1 Complex C 16 h 12 N 4 o 4 Cu unit cell and measurement parameters

[0027]

[0028] Table 2 Complex C 16 h 12 N 4 o 4 Cu bond length

[0029]

[0030] Table 3 Complexes [Cu(...

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Abstract

The invention relates to a 4-(3H) quinazolone copper peroxide complex and a synthetic method thereof. The molecular formula of the 4-(3H) quinazolone copper peroxide complex is C16H12N4O4Cu, and the molecular weight of the complex is 387.84. The synthetic method comprises the following steps: dissolving 4-(3H) quinazolone and copper nitrate tetrahydrate in an acetonitrile solvent; pouring the obtained mixed solution into a high-pressure polytetrafluoroethylene hydro-thermal reaction kettle, reacting for one day under a 150 DEG C hydro-thermal reaction condition and under a 130 DEG C hydro-thermal reaction condition, respectively, and cooling to the room temperature after reaction; filtering, collecting filtrate, and putting the filtrate in an oxygen atmosphere to prepare the 4-(3H) quinazolone copper peroxide complex. The 4-(3H) quinazolone copper peroxide complex disclosed by the invention has potential applications in the aspects including antisepsis, virus resistance, cancer resistance, hypertension resistance, hyperlipoidemia resistance, high cholesterol resistance, catalysis and the like.

Description

technical field [0001] The invention relates to a copper peroxide complex, in particular to a 4-(3H)quinazolone peroxycopper complex and a synthesis method of the complex. Background technique [0002] Pharmacological tests at home and abroad have proved that 4-(3H)quinazolone and its derivatives have antibacterial, antiviral, anticancer, antihypertensive, antihyperlipidemia and antihypercholesterolemic effects. The 4-(3H)quinazolone molecule has a good planar structure and abundant coordination atoms, and it is easy to form complexes, especially when its 2-position is substituted by carboxyl or hydroxymethyl, it is easier to form planar complexes. It can be predicted that this kind of complexes can easily interact with the DNA of tumors or viruses in the form of insertion, so as to achieve the purpose of anti-tumor and anti-virus. It can be seen that the metal drug complexes of 4(3H)-quinazolone have good potential application prospects. [0003] At the same time, in rece...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F1/08
Inventor 李石雄蒋毅民黄富平毛长霞覃慧珍
Owner GUANGXI NORMAL UNIV
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