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Aliskiren composition capsule

A composition and capsule technology, which is applied in the field of pharmaceuticals and pharmaceutical manufacturing, can solve the problems of not containing chitosan nanoparticles, etc., and achieve the effects of improving bioavailability, reducing dosage, and enhancing the effect of lowering blood pressure

Active Publication Date: 2014-01-29
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no pharmaceutical dosage form containing chitosan nanoparticles clinically at present.

Method used

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  • Aliskiren composition capsule
  • Aliskiren composition capsule
  • Aliskiren composition capsule

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Experimental program
Comparison scheme
Effect test

Embodiment

[0030] The preparation of embodiment, aliskiren composition capsule, in 1000 capsules.

[0031] prescription:

[0032]

[0033] 2. Preparation process.

[0034] ① Prepare the prescribed amount of povidone K30 with 20% ethanol solution to make 15% PVP solution, then add the prescribed amount of aliskiren to make it evenly dispersed, and prepare the drug-containing adhesive;

[0035] ② Pass the chitosan nanoparticles, microcrystalline cellulose, and croscarmellose sodium in the prescribed amount through 80-100 mesh sieves respectively, and mix them uniformly to prepare blank mixed auxiliary materials;

[0036] ③ The drug-containing adhesive obtained in step ① is mixed with the blank mixed auxiliary material obtained in step ② through the high-pressure sprayer of the spray dryer and dried into granules;

[0037] 4. The particles obtained in step 3. are passed through a 14-mesh sieve for granulation;

[0038] 5. Add magnesium stearate to the granules obtained in step 4, mix ...

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Abstract

The invention provides an aliskiren composition capsule, and belongs to the field of medicine and medicine production technology. The aliskiren composition capsule comprises 75mg of aliskiren, 35.5mg of chitosan, 30mg of povidone K30, and 3mg of magnesium stearate. Beneficial effects of the aliskiren composition capsule are that:1) the composition with a ratio of aliskiren to chitosan nanoparticle being 1:0.5 is capable of increasing bioavailability of aliskiren, and prolonging medicine action time; 2) the composition is capable of improving blood pressure reduction effect of aliskiren significantly, reducing dosage of aliskiren in clinic, and reducing untoward effects of aliskiren; and 3) chitosan can be taken as a disintegrating agent of the aliskiren composition capsule, so that dissolution rate of aliskiren is increased.

Description

Technical field: [0001] The invention relates to the technical field of medicine and medicine manufacture, in particular to an aliskiren composition capsule. Background technique: [0002] Aliskiren is the first oral, non-peptide, direct renin inhibitor synthesized in recent years. It can block the RAS system in the first link, reduce the activity of renin, reduce the production of AngII and aldosterone, and do not affect the immune system. The metabolism of kinins and prostaglandins plays a role in lowering blood pressure and treating cardiovascular diseases. It has stable physical and chemical properties, high water solubility, and hemifumarate is white or yellowish crystalline powder. On March 6, 2007, the antihypertensive drug Aliskiren (trade name: Tekturna) was approved by the US Food and Drug Administration (FDA). Tekturna on the market is a film-coated tablet containing Aliskiren free base 150mg and 300mg. Aliskiren is difficult to absorb (bioavailability is about...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/165A61K47/36A61P9/12A61P9/00
Inventor 汪六一汪金灿王淼
Owner HAINAN WEI KANG PHARMA QIANSHAN
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