Medicinal preparation for treating constipation and preparation method thereof

Abstract

The invention relates to a suppository for treating constipation and a preparation method thereof. The suppository is characterized in that a matrix and a proper dispersant are added into docusate sodium and mixed to prepare rectal administration suppository. The suppository is controllable in quality, stable and mild in property, can be used for preventing and treating various constipations in different ages, is suitable for postoperative constipations of haemorrhoids, senility and weakness, cardiovascular and cerebrovascular diseases and in proctology, obstetrics and gynecology departments and the like, and has higher clinical application value for oral intolerance or special patients.

Description

technical field [0001] The invention relates to a docusate sodium suppository and a preparation method thereof. Background technique [0002] Constipation is a kind of commonly encountered diseases, frequently-occurring disease, is to be the disease of main symptom with the constipation of defecation, difficulty in defecation. It can be caused by a variety of different pathological processes, resulting in the conduction dysfunction of the large intestine, the stool stays in the intestine for too long, and the water is absorbed, resulting in difficulty in defecation. In addition, the recovery period of intestinal inflammation, postoperative, postpartum, and adverse drug reactions can also cause temporary constipation. Constipation not only affects people's quality of life, but also brings trouble and inconvenience to life. It can also cause other diseases, especially the cardiovascular and cerebrovascular diseases of middle-aged and elderly people. People are always lookin...

AI Technical Summary

Problems solved by technology

We believe that the disadvantage of this patent is that in the production process, rhubarb and Glauber's salt are added to the substrate at a temperature of 60-90°C and stirred, and the control of cooling time is lacking in the production. As the temperature rises and the time prolongs, the content of sennoglycoside A decreases, and there is a problem that the activity of the drug decreases; secondly, rhubarb and mirabilite are cold drugs, which "repel down and attack fire" and "attack dryness in the intestines". "It is often used for constipation in adults, but it is not suitable for patients after surgery or children, etc.

[0004] When docusate sodium is mixed with a water-soluble base or a fat-soluble base or both bases to prepare suppositories, there is a problem of uneven drug solution. After mixing, the product has precipitation and color difference, which affects the uniformity and appearance of the drug content of the suppository after pouring, which is not conducive to the drug. Production control and product application

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