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42results about How to "Adapt to industrialized mass production" patented technology

Process for producing adipic acid and hexanediamine by depolymerization of nylon-66

The invention relates to a kind of technology for manufacturing adipic acid and hexane diamine by depolymerization with nylon-66 (hexamethylene diammonium adipate), which composed with acidolysis section, cooling and crystallization section, virgin acid separation section, recrystallization section, neutralization section, and refining section. Firstly, take acidolysis to get adipic acid; after, add alkali, take neutralization reaction to get hexane diamine. The acid used in acidolysis section is sulfuric acid, and the alkali used in neutralization reaction is lime cream. This technology adapts to industrialized grest production, can solve problem of high operating cost in industrial production of waste nylon-66 depolymerization production enterprise, and can get adipic acid and hexane diamine with higher purity. And also it has no new pollution and higher economic effect and social benefit.
Owner:宁波敏特尼龙工业有限公司

Dexrazoxane-containing composition and preparation method thereof, and dexrazoxane freeze-drying preparation and redissolving solvent thereof

The invention relates to the field of medicine, in particular relates to the fields of preparation and application of dexrazoxane, and more particularly relates to a dexrazoxane-containing composition and a preparation method thereof, and a dexrazoxane freeze-drying preparation and a redissolving solvent thereof. The dexrazoxane-containing composition is a solution consisting of dexrazoxane, hydrochloric acid, water and tertiary butanol, wherein the dexrazoxane concentration of the composition is 20 to 30 mg / mL. The dexrazoxane freeze-drying preparation provided by the invention has excellent stability and the preparation method is easy to industrialize.
Owner:JIANGSU AOSAIKANG PHARMA CO LTD

Stable enalapril maleate capsules and preparation method thereof

The invention relates to stable enalapril maleate capsules and a preparation method thereof, and belongs to the technical field of medicine. Enalapril maleate, lactose monohydrate, microcrystalline cellulose, startch, hydroxypropyl methyl cellulose, sodium alga acid, poloxamer 407, polyethylene glycol 4000 and L-arginine are preferably used as medical components of the stable enalapril maleate capsules, the degradation speed of the enalapril maleate is remarkably decreased through the mutual synergistic effect, the stability of the enalapril maleate capsules is greatly improved, and it is ensured that clinical medicine is safe, effective and capable of being stored for a long time.
Owner:CSPC OUYI PHARM CO LTD

Preparation method of compound dienogest

InactiveCN102964419AEasy to getHigh yieldSteroidsDiketoneCompound 17
The invention discloses a preparation method of compound dienogest, comprising the following steps of: reacting a compound steroidal estrogens-5(10),9(11)-diene-3,17-diketone-3,3-ethylidene ketal serving as a raw material with cyanmethyl lithium obtained by reacting acetonitrile with n-butyl lithium at the reaction temperature of -50 DEG C to -35 DEG C; thus obtaining a compound 17alpha-cyanmethyl-17beta-hydroxy-5(10),9(11)-steroidal estrogens diene-3,17-diketone-3,3-ethylidene ketal; carrying out deprotection transposition to obtain 17alpha-cyanmethyl-17beta-hydroxy-13beta-methylsterane-4,9-diketone-3-ketone; and refining to obtain a dienogest high-quality product. The preparation method disclosed by the invention has the advantages of very simple route, novelty, easily available and cheap raw materials, low cost, no-toxic or low-toxic raw materials, short synthetic route, moderate conditions, easiness for operation, stability for amplification and high yield, and can be suitable for industrial production.
Owner:ZHEJIANG XIANJU PHARMA

Method for preparing doramectin

The invention provides a new preparation method of doramectin, and in particular relates to a method for fermenting doramectin. The method is characterized by comprising a step of adding cyclohexanol carboxylic acid or salt of the cyclohexanol carboxylic acid twice in a fermentation process, wherein the first addition time of the cyclohexanol carboxylic acid or the salt of the cyclohexanol carboxylic acid is 22-60 hours after fermentation, and the second addition time of the cyclohexanol carboxylic acid or the salt of the cyclohexanol carboxylic acid is 170-194 hours after fermentation. The method is high in fermentation yield and suitable for industrial massive production, and can be applied to production of doramectin by a 500-L fermentation tank in a fermentation manner.
Owner:LIVZON NEW NORTH RIVER PHARMA

Air conditioning duct for rail vehicle and preparation method of air conditioning duct

The invention discloses an air conditioning duct for a rail vehicle. The duct is a composite pipe, and sequentially comprises an inner side layer, a fiber-reinforced aerogel felt layer and an outer side layer from inside to outside, wherein the inner side layer and the outer side layer are solidified prepreg or metal sheets. The air conditioning duct for the rail vehicle is a pipe which can be directly spliced and installed; the middle fiber-reinforced aerogel layer is light in weight, has a prominent thermal insulation effect, and is an incombustible material, so that the air conditioning duct for the rail vehicle has good fire resistance and thermal insulation effect; since the fiber-reinforced aerogel material is encapsulated between the solidified prepreg layers, after the duct is installed on a bullet train, the problem that the fiber-reinforced aerogel material drops powder is not caused regardless of how the train drives the duct to vibrate, and the thermal insulation effect isaccordingly stable and lasting.
Owner:CHANGZHOU INST OF LIGHT IND TECH

Oral ulcer mucoadhesive film and preparation method thereof

The invention provides an oral ulcer mucoadhesive film and a preparation method thereof. The oral ulcer mucoadhesive film is prepared by honeysuckle flower, menthol, vitamin B [2], borneol, tetracaine hydrochloride, sorbic acid, prednisone acetate, chlortetracycline hydrochloride, glycerin, stevioside, ethanol PVA 17-88 and purified water. Compared with the prior art, the film has good flexibility and tensile strength, can rapidly being expended and dissolved when meets water, a high-density protection drug film layer is formed on the oral cavity mucous membrane, and the effect for rapidly relieving swelling and pain with long term can be reached; oral cavity mucous membrane is employed for direction drug administration, the drug can be directly effected on the disease, simultaneous treatment of principal and subordinate symptoms can be reached, curative effect is fully performed; a lattice impression technology is employed on the technology, administration with divided dose is accurate, curative effect is increased, quality is stable, the oral ulcer mucoadhesive film has no toxic and side effect for oral cavity, and is safe and effective; and has the advantages of small volume, light weight, and convenient carrying and usage.
Owner:刘从荡

Preparation method of hexamethylenediamine piperidine

The invention discloses a preparation method of N,N-bis(2,2,6,6-tetramethyl-4-piperidinyl)-1,6-hexamethylenediamine (called hexamethylenediamine piperidine for short). The preparation method comprises the following steps: 1) carrying out a dehydration reaction on 2,2,6,6-tetramethyl-4-piperidone (called tetramethyl piperidone for short) and 1,6-hexanediamine to prepare a Schiff base intermediate; 2) carrying out a hydrogenation reaction on the Schiff base intermediate in the presence of a catalyst to obtain hexamethylenediamine piperidine. The preparation method disclosed by the application is low in reaction pressure, and the requirements of the bearing pressure of equipment are reduced, so that the production safety is greatly improved and the cost is reduced; a non-polar solvent is used, so that side effects are reduced, and a post-treatment method is simple and convenient, so that the production efficiency is increased, industrialized mass production can be adapted better, and the obtained target compound is high in purity and slight in colour.
Owner:JIANGSU FEIXIANG CHEM

Cefprozil suspension and preparation method thereof

The invention discloses cefprozil suspension. The cefprozil suspension is prepared through the following steps that 1, a diluent and microcrystalline cellulose & sodium carboxymethylcellulose are placed in a wet type granulator to be premixed; 2, cosolvent and wetting agents are added to conduct wet granulation; 3, whole grains are dried and marked as the material A; 4, cefprozil, suspending agents and wetting agents are mixed with the material A in an equivalent progressively-increasing mode, and the mixture is subpackaged after being evenly mixed, and the cefprozil suspension is obtained; the suspending agents are selected from one of xanthan gum or sodium carboxymethylcellulose or hydroxypropyl methyl cellulose; the weight proportion of the microcrystalline cellulose & sodium carboxymethylcellulose and suspending agents ranges from 2:1 to 8:1; the wetting agents are folic acid solutions with the concentration being 1 wt%. The cefprozil suspension is low in impurity content, high in dissolution rate, good in stability, even in main medicine spreading and simple in preparing process, no special equipment is needed, and the cefprozil suspension is capable of being suitable for industrialized mass production.
Owner:NORTH CHINA PHARMA HEBEI HUAMIN PHARMA

Azlocillin sodium medicinal composition for injection and preparation method for azlocillin sodium medicinal composition for injection

The invention discloses an azlocillin sodium medicinal composition, namely azlocillin sodium nanoparticle injection. The azlocillin sodium nanoparticle injection consists of azlocillin sodium, a carrier material, stabilizer and excipient, and the effective average particle size of nanoparticles is 10 to 200nm. The invention discloses a preparation method for the injection; and the method comprises the following steps of: mixing the azlocillin sodium and the stabilizer in water for injection, adjusting pH value, and adding the carrier material and the excipient to obtain the azlocillin sodium nanoparticle injection. The injection has the advantages of high redissolution performance, excellent stability, high medicine loading capacity and the like, and the process is suitable for industrial large-scale production.
Owner:海南美好西林生物制药有限公司

Method for making hand-made paper by dry method

The invention relates to a method for making handmade paper by a dry method, wherein, bamboo is adopted as raw material, dry paper pulp is obtained after the bamboo is crashed, a dry paper pulp sheet can be obtained from the dry paper pulp by extrusion, the dry paper pulp sheet is further dispersed into fiber, and the dry paper pulp fiber enters an air channel in the suspension form under the action of an airflow generated by an induced draft fan and is intercepted by a polyester net to form a uniform dry paper pulp layer which is covered with a fixed layer; under the holding of the upper fixed layer and the lower polyester net, wet paper is formed by the dry paper pulp layer treated with water absorption by a water supplying tank, the wet paper is separated from the fixed layer and the polyester net after being extruded, and the handmade paper can be obtained form the separated wet paper by drying. The method for making the handmade paper has only one harmful chemical, i.e., alkali liquor which is added in the production process, and gas and liquid are not discharged in the production process to pollute the environment; in the pulping process, the pulp outcome rate of the raw material reaches more than 95 percent, the sizing agent does not need washing and can not be lost, thus utilizing the bamboo resources maximally and saving the raw material.
Owner:HUIBEI ZIGUIHENGKANG FURNITURE

Drug combination of mezlocillin sodium for injection and preparation method of same

The invention discloses a drug combination of mezlocillin sodium, namely mezlocillin sodium nanoparticle injection which comprises mezlocillin sodium, a carrier material, a stabilizing agent and an excipient. The average effective particlesize of nanoparticle is 10 to 20 nm. The preparation method of the injection comprises the steps of mixing the mezlocillin sodium and the stabilizing agent in water for injection, adjusting pH value, and then adding the carrier material and the excipient into the mezlocillin sodium and the stabilizing agent. The mezlocillin sodium nanoparticle injection has the advantages of good re-solubility, good stability, high drug loading capacity and the like, and the method is suitable for industrial production.
Owner:海南美好西林生物制药有限公司

Tabletted Moringa tree leaf extract candy, and production method and application thereof

PendingCN108740261AUnique flavorFast and complete absorptionMetabolism disorderConfectioneryFlavorBioavailability
The invention belongs to the technical field of foods and functional foods, and discloses a tabletted Moringa tree leaf extract candy, and a production method and an application thereof. The tablettedMoringa tree leaf extract candy comprises dry Moringa tree leaf extract, auxiliary materials and magnesium stearate. The production method comprises the following steps: adding a Moringa tree leaf raw material into water, carrying out heating extraction to obtain a Moringa tree leaf extract liquid, concentrating the extract liquid to obtain Moringa tree leaf extract, drying the Moringa tree leafextract to obtain the dry Moringa tree leaf extract, crushing the dry extract, adding the auxiliary materials and the magnesium stearate, and carrying out granulation, straightening and tabletting molding processes to produce the tabletted Moringa tree leaf extract candy. The tabletted Moringa tree leaf extract candy is a novel leisure food with the advantages of pharmacological action, unique taste flavor, good palatability, completeness in absorption in human bodies, high bioavailability, small use amount and convenience in carrying and eating.
Owner:SOUTH CHINA AGRI UNIV

Bone reinforcing and muscle stretching medicine for treating cervical spondylotic radiculopathy and preparation method thereof

The invention relates to a traditional Chinese medicine preparation, in particular to a bone reinforcing and muscle stretching medicine for treating cervical spondylotic radiculopathy and a preparation method thereof. The effective ingredients in drynaria rhizome, leatherleaf milletia, desertliving cistanche, kudzu root, hawthorn, barrenwort and dregs of a decoction are entirely extracted and prepared to improve the transfer rate of the effective ingredients and to fully apply the medicinal materials. The extraction rate of the effective ingredients is improved and the pharmacological activity is greatly enhanced. The effective ingredients are extracted and processed on a condition of guaranteeing the effect of corydalis tuber, so that the dosage is reduced while the treatment effect is not reduced. As shown in the test, the technique of the invention can be used for extracting more effective ingredients to play the treatment role of the medicine so as to better guarantee the clinicaltreatment effect of the medicine, and the medicine is employed in such common orthopedics diseases as cervical spondylotic radiculopathy caused by liver and kidney deficiency and cold-dampness collateral obstruction so as to better satisfy the demands in clinical medical treatment.
Owner:TONGHUA GOLDEN-HORSE PHARM IND CO LTD

Synthesis method and application of 1, 3-aza-silane compound

The invention discloses a synthesis method and application of 1, 3-aza-silane compounds, and belongs to the technical field of chemical synthesis of silicon nitrogen compounds. The inventor provides a novel synthesis method of a precursor compound 1, 3-aza-silane compound, and the precursor compound 1, 3-aza-silane compound is used as an initial raw material for preparing silicon-substituted indoline or other pharmaceutical compositions, so that the subsequent preparation method is easy to operate, low in related reagent risk, not harsh in reaction condition and the like, and further, the 1, 3-aza-silane compound is ensured to be high in yield. The 1, 3-aza-silane compound has strong applicability when being used as a reaction substrate, realizes the synthesis of silicon-substituted indoline, and provides reference precursor compound selection for new drug research and development and the like.
Owner:SICHUAN UNIV

Medicinal preparation for treating constipation and preparation method thereof

The invention relates to a suppository for treating constipation and a preparation method thereof. The suppository is characterized in that a matrix and a proper dispersant are added into docusate sodium and mixed to prepare rectal administration suppository. The suppository is controllable in quality, stable and mild in property, can be used for preventing and treating various constipations in different ages, is suitable for postoperative constipations of haemorrhoids, senility and weakness, cardiovascular and cerebrovascular diseases and in proctology, obstetrics and gynecology departments and the like, and has higher clinical application value for oral intolerance or special patients.
Owner:田普森

Boiler heating device

The invention discloses a boiler heating device. The boiler heating device is characterized by comprising a boiler water inlet (1), a pipe box cover (2), a small pipe plate (3), a boiler water outlet(4), a large pipe plate (5), a converted gas outlet (6), a shell (7), a baffle plate (8), a bayonet tube (9), a sleeve pipe (10), a gas distributor (11), a heat insulation layer (12), a converted gasinlet (13) and a water leg (14), wherein the boiler water inlet (1) is arranged on the shell (7); the pipe box cover (2) is arranged below the boiler water inlet (1); the small pipe plate (3) is arranged below the pipe box cover (2); the boiler water outlet (4) is arranged below the small pipe plate (3); the large pipe plate (5) is arranged below the boiler water outlet (4); the converted gas outlet (6) is arranged below the large pipe plate (5); the baffle plate (8) is arranged below the shell (7); the bayonet tube (9) is arranged below the baffle plate (8); the sleeve pipe (10) is arranged below the bayonet tube (9); and the heat insulation layer (12) is arranged in the shell (7). The boiler heating device is simple and reasonable in structural design, long in service life, small in size, excellent in heating effect, and is extremely applicable to industrial production.
Owner:陈跃华

High-activity probiotic product with gastrointestinal tract regulating function and preparation method thereof

PendingCN113826901AConducive to the preservation of high activityReasonable ratioFood ingredient as antioxidantFood freezingGlycerolMannitol
The invention discloses a high-activity probiotic product with a gastrointestinal tract regulating function and a preparation method thereof. The high-activity probiotic product with the gastrointestinal tract regulating function is composed of an anti-gastric acid protective layer, an anti-oxidation layer and a core protective layer. The anti-gastric acid protective layer comprises the following components of hydroxypropyl starch, glycerol, purified water, D-mannitol and an additive in a weight ratio of (80-120): (20-40): (60-150): (4.5-9.5): (2.05-6.1); the weight ratio of the components of the core protective layer is that the weight ratio of the compound probiotic powder to the prebiotics to the plant dry powder or extract is (1-20): (1-30): (1-20); and the weight ratio of the components of the anti-oxidation layer is that the weight ratio of the mono / diglycerol fatty acid ester to the linseed oil is (1-5): (70-99). The invention further discloses a preparation method of the high-activity probiotic product with the gastrointestinal tract regulating function, and the preparation method is easy to operate, low in production cost and suitable for industrial large-scale production.
Owner:帅维佳

Method for making hand-made paper by dry method

The invention relates to a method for making handmade paper by a dry method, wherein, bamboo is adopted as raw material, dry paper pulp is obtained after the bamboo is crashed, a dry paper pulp sheet can be obtained from the dry paper pulp by extrusion, the dry paper pulp sheet is further dispersed into fiber, and the dry paper pulp fiber enters an air channel in the suspension form under the action of an airflow generated by an induced draft fan and is intercepted by a polyester net to form a uniform dry paper pulp layer which is covered with a fixed layer; under the holding of the upper fixed layer and the lower polyester net, wet paper is formed by the dry paper pulp layer treated with water absorption by a water supplying tank, the wet paper is separated from the fixed layer and the polyester net after being extruded, and the handmade paper can be obtained form the separated wet paper by drying. The method for making the handmade paper has only one harmful chemical, i.e., alkali liquor which is added in the production process, and gas and liquid are not discharged in the production process to pollute the environment; in the pulping process, the pulp outcome rate of the raw material reaches more than 95 percent, the sizing agent does not need washing and can not be lost, thus utilizing the bamboo resources maximally and saving the raw material.
Owner:HUIBEI ZIGUIHENGKANG FURNITURE

Method for extracting cis-form carboxylic acid and trans-form carboxylic acid from mixed acid with cis-form and trans-form carboxylic acid isomers

The invention relates to a method for extracting cis-form carboxylic acid and trans-form carboxylic acid from mixed acid with cis-form and trans-form carboxylic acid isomers. The method includes the steps that the mixed acid with the cis-form and trans-form carboxylic acid isomers firstly reacts with ammonia gas to generate cis-form carboxylic acid ammonium salt and trans-form carboxylic acid ammonium salt, the cis-form carboxylic acid ammonium salt and the trans-form carboxylic acid ammonium salt are extracted from the mixed acid according to the characteristic that the solubility of the cis-form carboxylic acid ammonium salt in solvents and the solubility of the trans-form carboxylic acid ammonium salt in the solvents are different, and then the cis-form carboxylic acid ammonium salt and the trans-form carboxylic acid ammonium salt are reduced to be the corresponding cis-form carboxylic acid and the corresponding trans-form carboxylic acid through chemical reactions. The method can be used for industrialization mass production.
Owner:GUANGXI HAOWANG BIOTECH

Bag type dust collector for pharmacy

The invention discloses a bag type dust collector for pharmacy, and is characterized in that the bag type dust collector comprises an upper box body (2), a perforated plate (3), a filter bag (4), a middle box body (5), a lower box body (7), a discharge valve (8) and a steam pocket (10); the middle box body (5) is arranged below the upper box body (2); the perforated plate (3) is arranged at the joint of the inner ends of the upper box body (2) and the middle box body (5); the filter bag (4) is arranged in the middle box body (5), the upper end of the filter bag (4) is arranged in the perforated plate (3) in a sleeving manner, the steam pocket (10) is arranged at the outer end of the middle box body (5) and communicates with an electromagnetic valve (9); the lower box body (7) is arranged at the lower end of the middle box body (5), and the discharging valve (8) is arranged at the bottom end of the lower box body (7). The structure design is simple and reasonable, and the effect of removing impurities is good.
Owner:江苏康林贝医疗器械有限公司

Cutting type steel plate machine

The invention discloses a cutting type steel plate machine, which comprises a hydraulic device (1) and a cutting device (6); it is characterized in that: the hydraulic device (1) is provided with a controller (8), the controller (8) A support (3) is provided on one side of the support (3); a cutting device (6) is provided under the support (3), and a cutting head group (7) is provided on the cutting device (6); the support (3) passes through the pipeline (2 ) is connected with the cutting head group (7), the cutting head group (7) is provided with a track (4), the cutting device (6) is provided with a conveying plate (9), and the conveying plate (9) is provided with There are fixed rollers (5).
Owner:李秀琴
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