42results about How to "Adapt to industrialized mass production" patented technology

The invention relates to a kind of technology for manufacturing adipic acid and hexane diamine by depolymerization with nylon-66 (hexamethylene diammonium adipate), which composed with acidolysis section, cooling and crystallization section, virgin acid separation section, recrystallization section, neutralization section, and refining section. Firstly, take acidolysis to get adipic acid; after, add alkali, take neutralization reaction to get hexane diamine. The acid used in acidolysis section is sulfuric acid, and the alkali used in neutralization reaction is lime cream. This technology adapts to industrialized grest production, can solve problem of high operating cost in industrial production of waste nylon-66 depolymerization production enterprise, and can get adipic acid and hexane diamine with higher purity. And also it has no new pollution and higher economic effect and social benefit.

The invention relates to the field of medicine, in particular relates to the fields of preparation and application of dexrazoxane, and more particularly relates to a dexrazoxane-containing composition and a preparation method thereof, and a dexrazoxane freeze-drying preparation and a redissolving solvent thereof. The dexrazoxane-containing composition is a solution consisting of dexrazoxane, hydrochloric acid, water and tertiary butanol, wherein the dexrazoxane concentration of the composition is 20 to 30 mg/mL. The dexrazoxane freeze-drying preparation provided by the invention has excellent stability and the preparation method is easy to industrialize.

The invention relates to stable enalapril maleate capsules and a preparation method thereof, and belongs to the technical field of medicine. Enalapril maleate, lactose monohydrate, microcrystalline cellulose, startch, hydroxypropyl methyl cellulose, sodium alga acid, poloxamer 407, polyethylene glycol 4000 and L-arginine are preferably used as medical components of the stable enalapril maleate capsules, the degradation speed of the enalapril maleate is remarkably decreased through the mutual synergistic effect, the stability of the enalapril maleate capsules is greatly improved, and it is ensured that clinical medicine is safe, effective and capable of being stored for a long time.

A vaginal effervescent tablet of miconazole nitrate is proportionally prepared from miconazole nitrate, tartaric acid, sodium dicarbonate, microcrystalline cellulose, polysorbitate, carboxymethyl starch sodium and magnesium stearate.

The invention discloses a preparation method of compound dienogest, comprising the following steps of: reacting a compound steroidal estrogens-5(10),9(11)-diene-3,17-diketone-3,3-ethylidene ketal serving as a raw material with cyanmethyl lithium obtained by reacting acetonitrile with n-butyl lithium at the reaction temperature of -50 DEG C to -35 DEG C; thus obtaining a compound 17alpha-cyanmethyl-17beta-hydroxy-5(10),9(11)-steroidal estrogens diene-3,17-diketone-3,3-ethylidene ketal; carrying out deprotection transposition to obtain 17alpha-cyanmethyl-17beta-hydroxy-13beta-methylsterane-4,9-diketone-3-ketone; and refining to obtain a dienogest high-quality product. The preparation method disclosed by the invention has the advantages of very simple route, novelty, easily available and cheap raw materials, low cost, no-toxic or low-toxic raw materials, short synthetic route, moderate conditions, easiness for operation, stability for amplification and high yield, and can be suitable for industrial production.

The invention provides a new preparation method of doramectin, and in particular relates to a method for fermenting doramectin. The method is characterized by comprising a step of adding cyclohexanol carboxylic acid or salt of the cyclohexanol carboxylic acid twice in a fermentation process, wherein the first addition time of the cyclohexanol carboxylic acid or the salt of the cyclohexanol carboxylic acid is 22-60 hours after fermentation, and the second addition time of the cyclohexanol carboxylic acid or the salt of the cyclohexanol carboxylic acid is 170-194 hours after fermentation. The method is high in fermentation yield and suitable for industrial massive production, and can be applied to production of doramectin by a 500-L fermentation tank in a fermentation manner.

The invention provides an oral ulcer mucoadhesive film and a preparation method thereof. The oral ulcer mucoadhesive film is prepared by honeysuckle flower, menthol, vitamin B [2], borneol, tetracaine hydrochloride, sorbic acid, prednisone acetate, chlortetracycline hydrochloride, glycerin, stevioside, ethanol PVA 17-88 and purified water. Compared with the prior art, the film has good flexibility and tensile strength, can rapidly being expended and dissolved when meets water, a high-density protection drug film layer is formed on the oral cavity mucous membrane, and the effect for rapidly relieving swelling and pain with long term can be reached; oral cavity mucous membrane is employed for direction drug administration, the drug can be directly effected on the disease, simultaneous treatment of principal and subordinate symptoms can be reached, curative effect is fully performed; a lattice impression technology is employed on the technology, administration with divided dose is accurate, curative effect is increased, quality is stable, the oral ulcer mucoadhesive film has no toxic and side effect for oral cavity, and is safe and effective; and has the advantages of small volume, light weight, and convenient carrying and usage.

The invention discloses a preparation method of N,N-bis(2,2,6,6-tetramethyl-4-piperidinyl)-1,6-hexamethylenediamine (called hexamethylenediamine piperidine for short). The preparation method comprises the following steps: 1) carrying out a dehydration reaction on 2,2,6,6-tetramethyl-4-piperidone (called tetramethyl piperidone for short) and 1,6-hexanediamine to prepare a Schiff base intermediate; 2) carrying out a hydrogenation reaction on the Schiff base intermediate in the presence of a catalyst to obtain hexamethylenediamine piperidine. The preparation method disclosed by the application is low in reaction pressure, and the requirements of the bearing pressure of equipment are reduced, so that the production safety is greatly improved and the cost is reduced; a non-polar solvent is used, so that side effects are reduced, and a post-treatment method is simple and convenient, so that the production efficiency is increased, industrialized mass production can be adapted better, and the obtained target compound is high in purity and slight in colour.

The invention discloses cefprozil suspension. The cefprozil suspension is prepared through the following steps that 1, a diluent and microcrystalline cellulose & sodium carboxymethylcellulose are placed in a wet type granulator to be premixed; 2, cosolvent and wetting agents are added to conduct wet granulation; 3, whole grains are dried and marked as the material A; 4, cefprozil, suspending agents and wetting agents are mixed with the material A in an equivalent progressively-increasing mode, and the mixture is subpackaged after being evenly mixed, and the cefprozil suspension is obtained; the suspending agents are selected from one of xanthan gum or sodium carboxymethylcellulose or hydroxypropyl methyl cellulose; the weight proportion of the microcrystalline cellulose & sodium carboxymethylcellulose and suspending agents ranges from 2:1 to 8:1; the wetting agents are folic acid solutions with the concentration being 1 wt%. The cefprozil suspension is low in impurity content, high in dissolution rate, good in stability, even in main medicine spreading and simple in preparing process, no special equipment is needed, and the cefprozil suspension is capable of being suitable for industrialized mass production.

The invention discloses a drug combination of mezlocillin sodium, namely mezlocillin sodium nanoparticle injection which comprises mezlocillin sodium, a carrier material, a stabilizing agent and an excipient. The average effective particlesize of nanoparticle is 10 to 20 nm. The preparation method of the injection comprises the steps of mixing the mezlocillin sodium and the stabilizing agent in water for injection, adjusting pH value, and then adding the carrier material and the excipient into the mezlocillin sodium and the stabilizing agent. The mezlocillin sodium nanoparticle injection has the advantages of good re-solubility, good stability, high drug loading capacity and the like, and the method is suitable for industrial production.

The invention discloses a plastering film for treating ulcerative stomatitis and its preparation, wherein the medicament is prepared from honeysuckle flower, menthol, vitamin B2, boneol, tetracaine hydrochloride, sorbic acid, prednisone acetate, chlortetracycline hydrochloride, glycerin, stevioside, ethanol, polyvinyl alcohol PVA17-88 and purified water.

The invention relates to a method for extracting cis-form carboxylic acid and trans-form carboxylic acid from mixed acid with cis-form and trans-form carboxylic acid isomers. The method includes the steps that the mixed acid with the cis-form and trans-form carboxylic acid isomers firstly reacts with ammonia gas to generate cis-form carboxylic acid ammonium salt and trans-form carboxylic acid ammonium salt, the cis-form carboxylic acid ammonium salt and the trans-form carboxylic acid ammonium salt are extracted from the mixed acid according to the characteristic that the solubility of the cis-form carboxylic acid ammonium salt in solvents and the solubility of the trans-form carboxylic acid ammonium salt in the solvents are different, and then the cis-form carboxylic acid ammonium salt and the trans-form carboxylic acid ammonium salt are reduced to be the corresponding cis-form carboxylic acid and the corresponding trans-form carboxylic acid through chemical reactions. The method can be used for industrialization mass production.

The invention discloses a bag type dust collector for pharmacy, and is characterized in that the bag type dust collector comprises an upper box body (2), a perforated plate (3), a filter bag (4), a middle box body (5), a lower box body (7), a discharge valve (8) and a steam pocket (10); the middle box body (5) is arranged below the upper box body (2); the perforated plate (3) is arranged at the joint of the inner ends of the upper box body (2) and the middle box body (5); the filter bag (4) is arranged in the middle box body (5), the upper end of the filter bag (4) is arranged in the perforated plate (3) in a sleeving manner, the steam pocket (10) is arranged at the outer end of the middle box body (5) and communicates with an electromagnetic valve (9); the lower box body (7) is arranged at the lower end of the middle box body (5), and the discharging valve (8) is arranged at the bottom end of the lower box body (7). The structure design is simple and reasonable, and the effect of removing impurities is good.