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Preparation method of sodium ferrous chlorophyll-ethyl cellulose microcapsule

A technology of ethyl cellulose and iron chlorophyllin, which is applied in the field of preparation of medicinal and food pigments, can solve the problems of sodium iron chlorophyllin microcapsules that have not yet been seen, achieve excellent physical and chemical stability, ensure curative effect, The effect of enhancing stability

Inactive Publication Date: 2014-02-12
香源丰(天津)酒业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Up to now, there is no research report on iron sodium chlorophyllin microcapsules, especially the preparation of iron sodium chlorophyllin microcapsules with ethyl cellulose

Method used

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Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0009] The present invention will be further described below in conjunction with the examples.

[0010] Main instruments: AEL-160 electronic balance; HH-S digital display constant temperature water bath; booster electric mixer; centrifuge; drug dissolution apparatus; KYKY2800 scanning electron microscope with a resolution of 4.5nm; laser particle size analyzer; .

[0011] Reagents and raw materials: carbon tetrachloride, petroleum ether, ethyl cellulose; sodium iron chlorophyllin.

[0012] specific steps

[0013] Take sodium iron chlorophyllin, add it to the carbon tetrachloride solution solvent of 2% ethyl cellulose, place it in a HH-S digital display constant temperature water bath at a constant temperature of 39 to 41°C, stir evenly at a speed of 350r / min, and prepare into iron sodium chlorophyllinate suspension; the iron sodium chlorophyllinate suspension is added to petroleum ether non-solvent while stirring (according to the weight ratio of selection), and the booster ...

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Abstract

The invention discloses a preparation method of a sodium ferrous chlorophyll-ethyl cellulose microcapsule, and belongs to the field of preparation of medicinal and food pigment. The sodium ferrous chlorophyll-ethyl cellulose microcapsule taking sodium ferrous chlorophyll as a capsule core and ethyl cellulose (EC) as a capsule material is prepared by the following steps: adding sodium ferrous chlorophyll in 2% carbon tetrachloride solution of ethyl cellulose serving as a solvent, and stirring in a thermostatic water bath to prepare sodium ferrous chlorophyll suspension; adding the sodium ferrous chlorophyll suspension in petroleum ether non-solvent while stirring, continuing stirring for 1 hour, centrifuging for 20min in a centrifugal machine, washing for a plurality of times by using petroleum ether, removing supernate, paving on the surface of a glass plate to dry in a drying oven, thus obtaining the sodium ferrous chlorophyll-ethyl cellulose microcapsule. EC serving as the capsule material has stable physical property and chemical property and extreme low toxicity; the microcapsule prepared from EC and other auxiliaries in a certain proportion has obvious sustained release effect, the effective blood concentration can be maintained for a long time, the microcapsule facilitates the patient, and the therapeutic effect of the medicine is guaranteed.

Description

technical field [0001] The invention relates to a preparation method of sodium iron chlorophyllin-ethyl cellulose microcapsules, belonging to the field of preparation methods of medicinal and food pigments. Background technique [0002] Sodium iron chlorophyllin (including iron (II) chlorophyllin and iron (III) chlorophyllin) is easily soluble in water or dilute alcohol solution, but insoluble in oils and fats. After research and testing, the sodium iron chlorophyllinate solution is stable against indoor light, but its stability against outdoor natural light is not ideal. In addition to being a good food coloring, sodium iron chlorophyllin can also be used as an iron fortifier in medicine. Shengxuening tablets made of sodium iron chlorophyllin have been successfully used in the treatment of iron deficiency anemia. This is the only dosage form of iron chlorophyllin sodium salt in China. Utilizing the characteristics of microcapsules, the further microencapsulation treatment...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/409A61K47/38A61P3/02A61P7/06
Inventor 李金才
Owner 香源丰(天津)酒业有限公司
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