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Microbe effervescent tablet and preparation method thereof

A technology of effervescent tablets and microorganisms, applied in the field of probiotic effervescent tablets and its preparation, can solve the problems of lack of application of excipients, increased risk of microbial inactivation, lack of applicability of effervescent tablets, etc., and achieve the goal of prolonging the storage time Effect

Active Publication Date: 2014-02-19
ACAD OF NAT FOOD & STRATEGIC RESERVES ADMINISTRATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are very few reports on oral microbial effervescent tablets in existing public studies
[0007] (2) Effervescent tablets can be divided into wet granulation, dry granulation and direct powder compression from the granulation process; most of the existing patents are wet granulation, and the stability of the preparation and the comparison of the three, the stability of the probiotic activity Lack of consideration and response;
[0008] (3) The effervescent tablet technology research is only carried out for a certain genus or strain, and the technology lacks the applicability for making effervescent tablets with most probiotics
[0010] (5) The lack of application of excipients aimed at protecting the activity of microorganisms increases the risk of inactivation of microorganisms during processing, use and storage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (1) Preparation of MRS medium

[0042]The preparation of MRS medium: take peptone 1% (W / V), glucose 2% (W / V), beef extract 1% (W / V), anhydrous sodium acetate 0.5% (W / V), yeast extract Ointment 0.5% (W / V), Tween 800.1ml, Dipotassium hydrogen phosphate 0.2% (W / V), Diammonium hydrogen citrate 0.2% (W / V), Magnesium sulfate heptahydrate 0.058% (W / V) , manganese sulfate monohydrate 0.025% (W / V), water 100ml, adjust the pH to 7.0±0.2; use moist heat sterilization, the temperature is 115 ℃, and the sterilization time is 30min.

[0043] (2) Preparation of bacteria slime

[0044] a. Select Enterococcus faecium (CGMCC2516), culture the strain in MRS medium under microaerobic conditions (0.5 mg / L dissolved oxygen) at 35°C for 8 hours, and obtain the first-grade seed liquid of Enterococcus faecium;

[0045] b. Put the primary seed liquid of the bacteria into the seed tank according to the inoculum amount of 2% to expand the cultivation, and cultivate it in the MRS medium for 6 hou...

Embodiment 2

[0066] (1) Preparation of LB medium

[0067] Prepare LB medium: take tryptone 1% (W / V), yeast extract 0.5% (W / V), sodium chloride 1% (W / V), water 100ml, pH7.0±0.2; Sterilization, 121°C, 20min.

[0068] (2) Preparation of bacteria slime

[0069] a. Enterococcus faecalis (ATCC19433) and Lactobacillus plantarum (CGMCC1.2437) were selected, and the strains were cultured in LB medium for 8 hours under microaerobic conditions (0.5mg / L dissolved oxygen) at 35°C to obtain the first grade seed liquid;

[0070] b. Put the primary seed liquids of the two bacteria into seed tanks according to the inoculum amount of 2% to expand the cultivation, and cultivate them in LB medium for 8 hours under microaerobic conditions at 35°C to obtain the secondary seed liquids;

[0071] c. Put the secondary seed liquid into the fermenter according to the inoculum amount of 5% for fermentation and culture, use LB medium for fermentation and culture, and cultivate it under micro-aerobic conditions at 38...

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PUM

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Abstract

The invention discloses a microbe effervescent tablet. The effervescent tablet comprises the following components in parts by weight: 1 to 5 parts of probiotics paste and 15 to 40 parts of an acid source, or 1 to 5 parts of probiotics paste and 10 to 40 parts of the acid source and further comprises a protecting agent and other matters. The invention further provides a method for preparing the effervescent tablet; the effervescing technology supports wet granulation, dry granulation and direct powder tabletting, and a suitable processing plan can be selected according to different microbes, different processing manners and different application manners; an auxiliary material for protecting microbe activity is added in the effervescent tablet, so that the preservation time of the microbe effervescent tablet can be prolonged.

Description

technical field [0001] The invention relates to microbial effervescent tablets, in particular to probiotic effervescent tablets and a preparation method thereof. Background technique [0002] The effervescent technology is to add carbonate and organic acid to the preparation, and generate CO when it meets water. 2 The technology of regulating drug release behavior by using gas; effervescent tablet is a tablet made according to this technical principle. It has the characteristics of easy to carry and use, uniform distribution in water, high bioavailability, etc., and has the advantages of both solid and liquid preparations. It has been widely used in medicine, food, health care products and other fields, with broad application prospects. [0003] Probiotics are a class of microorganisms that have beneficial effects on the host by affecting the intestinal microecology of humans or animals. [0004] The combination of probiotics and effervescent technology can be made into ta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A61K9/46A61P1/00A61K35/742A61K35/745A61K35/747
Inventor 韩伟张晓琳王大为汪洋张小溪
Owner ACAD OF NAT FOOD & STRATEGIC RESERVES ADMINISTRATION
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