Gatifloxacin liposome ophthalmic gel and preparation method thereof
A technology of gatifloxacin and cationic liposome, which is applied in the field of gatifloxacin liposome ophthalmic gel and its preparation, can solve the problem of large fluctuations in drug concentration, difficult control of dosage, and reduced frequency of use, etc. problems, to achieve the effects of quality control, broad industrialization prospects, and increased contact time
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Embodiment 1
[0024] Formulations were prepared according to the ingredients contained in the unit dosage forms shown in Table 1.
[0025] 1. Preparation process of samples 1 to 7:
[0026] (1) Place the phospholipids, cholesterol, and octadecylamine of the prescribed amount in a glass bottle, add an appropriate amount of ether to dissolve, then rotate the ether solution in the glass bottle to form a film on the inner wall of the glass bottle;
[0027] (2) the gatifloxacin of recipe quantity is dissolved in the phosphate buffer solution that pH is 6, adds in the glass bottle and constantly stirs, obtains gatifloxacin liposomal colostrum, colostrum is passed through high-pressure homogenizer in 1.4×10 6 Under the pressure of kPa, squeeze the emulsion through a 50nm membrane 5 times to obtain the gatifloxacin liposome solution. Add a preservative and an osmotic pressure regulator, adjust the pH value to 6.5, stir to make it uniform, and obtain liposome solution I;
[0028] (3) Add the pres...
Embodiment 2
[0043] prescription:
[0044]
[0045] Preparation:
[0046] (1) Place the phospholipids, cholesterol, and octadecylamine of the prescribed amount in a glass bottle, add an appropriate amount of ether to dissolve, then rotate the ether solution in the glass bottle to form a film on the inner wall of the glass bottle;
[0047] (2) the gatifloxacin of recipe quantity is dissolved in the phosphate buffer solution that pH is 6, adds in the glass bottle and constantly stirs, obtains gatifloxacin liposomal colostrum, colostrum is passed through high-pressure homogenizer in 1.4×10 6 Under the pressure of kPa, squeeze the emulsion through a 50nm membrane 5 times to obtain the gatifloxacin liposome solution. Add a preservative and an osmotic pressure regulator, adjust the pH value to 6.5, stir to make it uniform, and obtain liposome solution I;
[0048] (3) Add the prescribed amount of water-soluble gel matrix into 80% boiled water for injection, disperse evenly, sterilize by aut...
Embodiment 3
[0051] prescription:
[0052]
[0053] Preparation:
[0054] (1) Place the phospholipids, cholesterol, and octadecylamine of the prescribed amount in a glass bottle, add an appropriate amount of ether to dissolve, then rotate the ether solution in the glass bottle to form a film on the inner wall of the glass bottle;
[0055] (2) the gatifloxacin of recipe quantity is dissolved in the phosphate buffer solution that pH is 7, adds in the glass bottle and constantly stirs, obtains gatifloxacin liposomal colostrum, colostrum is passed through high-pressure homogenizer in 1.4×10 6 Under the pressure of kPa, squeeze the milk through a 50nm membrane for 3 times to obtain the gatifloxacin liposome solution. Add a preservative and an osmotic pressure regulator, adjust the pH to 6, stir to make it uniform, and obtain liposome solution I;
[0056] (3) Add the prescribed amount of water-soluble gel matrix into 80% boiled water for injection, disperse evenly, sterilize by autoclaving...
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