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Tooth desensitizer as well as preparation method and application thereof

A technology for desensitizing agents and teeth, applied in the field of tooth desensitizing agents, can solve problems such as dentin hypersensitivity, prolapse, and mutual fusion, and achieve prevention and treatment of oral diseases, excellent biocompatibility, and broad market prospects Effect

Inactive Publication Date: 2014-03-12
北京博恩康生物科技有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are serious defects in the application of silica particles to the second type of method: after the silica particles are immersed in the dentinal tubules, they cannot be effectively fused with each other and fixed in the dentinal tubules, thus easily detaching from the dentinal tubules
[0005] However, for the above-mentioned second type of method for treating dentin hypersensitivity, bioactive glass has not entered people's field of vision at all, and this is because: bioactive glass is difficult to prepare as very fine particles, and its particle size is usually in the range of tens of microns However, the diameter of dentinal tubules is only 3-4 μm near the medullary cavity and 1 μm near the enamel dentin junction, so it is difficult for bioactive glass to enter into the dentinal tubules
Therefore, although bioactive glass has excellent biocompatibility and has a very positive effect on oral treatment, it has not yet been shown that it can treat dentin hypersensitivity through the above-mentioned second type of method

Method used

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  • Tooth desensitizer as well as preparation method and application thereof
  • Tooth desensitizer as well as preparation method and application thereof
  • Tooth desensitizer as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] (1) Provide silica nanoparticles

[0048] Available in 100nm silica nanoparticles

[0049] Such as figure 1 The depth to which such silica nanoparticles can penetrate into dentinal tubules by surface application was characterized by confocal laser, as shown. The arrow shows the smeared side of the material, and a sloping sample boundary can be seen. The red light is excited by the rhodamine B dye encapsulated in the silica particles, which marks the location of the silica spheres, so the depth reached by the red area indicates the depth the material can reach inside the dentinal tubules, the deepest It can reach 160 microns, and the brightest part of the laser, that is, the universal penetration reaches 110 microns.

[0050] (2) Melting of bioactive glass

[0051] Bioactive glass purchased from Shanghai Silicon Health Biomaterials Co., Ltd. was heated to 1400°C to melt it.

[0052] (3) Dip the silica nanoparticles into the molten bioactive glass for 2 minutes, so t...

Embodiment 2

[0063] (1) Preparation of mesoporous silica nanoparticles

[0064] The ratio of raw materials is cetyltrimethylammonium bromide (CTAB): deionized water: sodium hydroxide: tetraethyl orthosilicate (TEOS) = 1: 8504: 2.55: 8.13 (molar ratio); Mix cetyltrimethylammonium bromide, deionized water and sodium hydroxide, stir the reaction system at 70°C until the temperature is stable, and after the cetyltrimethylammonium bromide is completely dissolved, add n- Ethyl silicate; the reaction system was kept at 70°C for 2 hours. After the reaction, the white solid was obtained by suction filtration and dried in an oven at 50°C for 10 hours; the obtained white powder sample was ground with a mortar and put into a crucible , calcined in a muffle furnace at 550°C for 4 hours to remove the template agent CTAB; the calcined sample was ground again to obtain mesoporous silica nanoparticles with ordered pores, the pore volume was 0.84cm3 / g, and the pore diameter was 3.0 nm;

[0065] The scanni...

Embodiment 3

[0074] (1) Preparation of mesoporous silica nanoparticles

[0075] The ratio of raw materials is cetyltrimethylammonium bromide (CTAB): deionized water: sodium hydroxide: tetraethyl orthosilicate (TEOS) = 1: 4859: 2: 8.13 (molar ratio); according to the above formula Mix cetyltrimethylammonium bromide, deionized water and sodium hydroxide, stir the reaction system at 70°C until the temperature is stable, and after the cetyltrimethylammonium bromide is completely dissolved, add n- Ethyl silicate; the reaction system was kept at 70°C for 2 hours. After the reaction, the white solid was obtained by suction filtration and dried in an oven at 50°C for 10 hours; the obtained white powder sample was ground with a mortar and put into a crucible , calcined in a muffle furnace at 550°C for 4 hours to remove the template agent CTAB; the calcined sample was ground again to obtain mesoporous silica nanoparticles with ordered pores, the pore volume was 0.89cm3 / g, and the pore diameter was 3...

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Abstract

The invention relates to a tooth desensitizer as well as a preparation method and application thereof. The tooth desensitizer provided by the invention is a powdery composite material, and comprises silicon dioxide nano-particles and bioactive glass layers coated on the surfaces of the mesoporous silicon dioxide nano-particles through fusion. The preparation method for the tooth desensitizer comprises the following steps: (1), providing the silicon dioxide nano-particles; (2), providing bioactive glass, heating the bioactive glass till the bioactive glass is fused; (3), immersing the silicon dioxide nano-particles into the fused bioactive glass to enable the surfaces of the silicon dioxide nano-particles to be coated with the bioactive glass; (4), cooling the silicon dioxide nano-particles coated with the bioactive glass on the surfaces, so as to form the powdery tooth desensitizer. The powdery tooth desensitizer provided by the invention can be mixed with water into a plaster, and can be coated on surfaces of teeth having a dentin hypersensitivity symptom to seal dentinal tubules relatively deep, so that external stimulation in the oral cavity can be isolated, and the effect of curing the dentin hypersensitivity can be achieved.

Description

technical field [0001] The invention relates to a tooth desensitizing agent, its preparation method and application. The tooth desensitizing agent of the present invention can overcome the shortcomings in the prior art, and can deeply seal the exposed dentine tubules, thereby isolating external stimuli in the oral cavity and achieving the effect of treating dentine sensitivity. Background technique [0002] Dentin hypersensitivity disease is mainly caused by irritation caused by exposure of dentine tubules to the oral environment. At present, the ideas for treating dentin sensitivity can be roughly divided into two categories: one is based on the theory of nerves and dentin fiber conduction theory, using toothpaste or varnishes containing potassium compounds such as potassium nitrate and potassium chloride to reduce the The sensitivity of the nerve endings, thereby reducing its response to external stimuli; the second type is based on hydrodynamics, reducing the diameter of...

Claims

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Application Information

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IPC IPC(8): A61K33/06A61K33/00A61K9/14A61P1/02A61P37/08
Inventor 甘少磊
Owner 北京博恩康生物科技有限公司
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