Magnetic nanoparticles with dual-heating function and preparation method thereof

A nano-magnetic, dual-heating technology, applied in the field of biomedical engineering, can solve problems such as single action, achieve uniform size, good stability, and inhibit cell proliferation.

Inactive Publication Date: 2014-03-12
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In summary: Magnetic induction hyperthermia and photothermotherapy have shown good application prospects in the field of basic research, but their effects are still relatively single

Method used

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  • Magnetic nanoparticles with dual-heating function and preparation method thereof
  • Magnetic nanoparticles with dual-heating function and preparation method thereof
  • Magnetic nanoparticles with dual-heating function and preparation method thereof

Examples

Experimental program
Comparison scheme
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preparation example Construction

[0034] 2.1 Fe 3 o 4 Preparation of magnetic nanoparticles

[0035] Adopt self-designed equipment, apply improved chemical co-precipitation method, use analytical pure FeCl 3 ·6H 2 O and FeCl 2 4H 2 O was prepared into 0.1mol / L FeCl with deionized water after deoxygenation treatment 3 solution and FeCl 2 Solution, molar ratio Fe 3+ : Fe 2+ =5:3 100ml 0.1mol / L FeCl 3 solution and 60ml of 0.1mol / L FeCl 2 The solution was mixed in the flask, and then 10ml of 1mol / L trisodium citrate solution and 50ml of 1mol / L ammonium hydroxide solution were prepared respectively with deionized water after deoxygenation treatment, and the mixture of trisodium citrate and ammonium hydroxide Quickly add FeCl under nitrogen protection, which is being vigorously stirred by magnetic force 3 and FeCl 2 Mixture ， A black precipitate appeared rapidly in the solution, and the stirring was continued for 30 minutes and then stopped. Mature in a water bath at 80°C for 30 minutes, then hold the ...

Embodiment 1

[0037] Embodiment 1: Dissolve Fe with deionized water after deoxygenation treatment 3 o 4 Nano magnetic particles to 0.01mol / L, ultrasonic treatment for 5 minutes, take 20ml and 20ml of 0.1mol / L trisodium citrate solution, mix and stir for 10 minutes. Then dilute the mixed solution with deionized water to 200ml, add 10ml of 0.1% auric acid solution, start heating the solution (equipped with a condensing reflux tube) until it boils, add 1ml of 1mol / L hydroxylamine hydrochloride one by one, continue heating and stirring , the color of the solution then changed from light yellow to brown, and finally turned into the characteristic red of gold colloid, and the heating was stopped. The magnetic nanoparticles are separated from the solution by using a permanent magnet, and washed repeatedly with 1mol / 1 hydrochloric acid to remove unwrapped or incompletely wrapped excess Fe 3 o 4 nano-magnetic particles, and washed 3 times with deionized water to obtain Fe 3 o 4 Au composite n...

Embodiment 2

[0038] Embodiment 2: Dissolve Fe with deionized water after deoxygenation treatment 3 o 4 Nano-magnetic particles to 0.05mol / L, ultrasonic treatment for more than 5 minutes, take 20ml and 30ml of 0.5mol / L trisodium citrate solution, mix and stir for more than 10 minutes. Then dilute the mixed solution with deionized water to 300ml, add 20ml of 0.5% auric acid solution, start heating the solution (equipped with a condensing reflux tube) until it boils, add 1ml of 1mol / L hydroxylamine hydrochloride one by one, continue heating and stirring , the color of the solution then changed from light yellow to brown, and finally turned into the characteristic red of gold colloid, and the heating was stopped. The magnetic nanoparticles are separated from the solution by using a permanent magnet, and washed repeatedly with 1mol / 1 hydrochloric acid to remove unwrapped or incompletely wrapped excess Fe 3 o 4 nano-magnetic particles, and washed 3 times with deionized water to obtain Fe 3...

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Abstract

The invention provides magnetic nanoparticles with a dual-heating function and a preparation method thereof. The preparation method is characterized in that ferroferric oxide (Fe3O4) nanoparticles are prepared and serve as cores, and the magnetic induction of the ferroferric oxide nanoparticles is used for targeting tumor cells and carrying out the magnetic thermal therapy; and gold is used as shells of the magnetic nanoparticles, and the photosensitivity of the gold is used for carrying out near-infrared thermal therapy; and the constructed novel Fe3O4@Au compound magnetic nanoparticles can simultaneously serve as a magnetic induction agent and a photosensitizer for tumor thermotherapy. The compound magnetic nanoparticles prepared by the method are injected into an animal model for tumor and can be used for carrying out magnetic thermal therapy and photo-thermal therapy on a living animal model. The treatment effect of the magnetic nanoparticles on tumor is obviously superior to that of a single treatment method.

Description

technical field [0001] The invention belongs to the field of biomedical engineering, and in particular relates to a nano-magnetic particle with double heating functions and a preparation method thereof. Background technique [0002] The hyperthermia of tumor tissue induced by Magnetic Nanoparticles (MNPs) is a potential treatment method, which has been evaluated in various in vitro animal models and has achieved promising results, and has entered phase I clinical trials . Hyperthermia is a therapeutic procedure based on the principle of increasing the temperature of human tissue to change the structure and function of cells, that is, when the temperature is increased to between 41°C and 42°C, it can induce tumor cell death. Because tumor cells are less tolerant to sudden increases in temperature than surrounding normal cells. An increase in temperature causes many enzymes and structural proteins to operate in cells, thereby changing cell proliferation and differentiation, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61P35/00B22F9/24
Inventor 张东生李云涛
Owner SOUTHEAST UNIV
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