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Long-acting compound sulfametoxydiazine sodium injection for veterinary use and preparation method thereof

A technology of sulfamethoxine sodium and methotrexate sodium, which is applied in the field of veterinary long-acting compound sulfamethoxine sodium injection and its preparation, and can solve problems such as vitamin B1 deficiency, large irritation, and lump formation , to achieve the effect of reducing toxic and side effects, reducing irritation, and saving labor

Active Publication Date: 2015-06-17
HUBEI WUDANG ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The compound sulfamethoxine sodium injection prepared according to the 2010 version quality standard of "Chinese Veterinary Pharmacopoeia" has two defects in clinical application: 1. The pH value of compound sulfamethoxine sodium is 10.0-11.0, which is an alkali After the alkaline injection is injected into the animal body, it is very irritating and often forms a local lump at the injection site
2. Sulfonamide drugs are highly toxic to the liver and kidney when administered in large quantities and for a long time. The imbalance of intestinal flora often causes vitamin B1 deficiency, resulting in side effects such as anorexia, leukopenia, and loss of appetite.

Method used

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  • Long-acting compound sulfametoxydiazine sodium injection for veterinary use and preparation method thereof
  • Long-acting compound sulfametoxydiazine sodium injection for veterinary use and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Weigh 50g of glycerol methylal, 100g of α-pyrrolidone, and 200g of polyethylene glycol 400 (PEG400) into the batching tank, heat to 70-80°C, add 150g of polyvinylpyrrolidone while stirring, and then Add 20 g of trimethoprim, continue to stir for 10-20 minutes until dissolved, set aside;

[0033] (2) Weigh 10-20g of water for injection into a stainless steel barrel and heat to 60-80°C, add sulfonamide to

[0034] Stir and dissolve 10 g of sodium methotrexate, set aside;

[0035] (3) Weigh 10-20g of water for injection into a stainless steel bucket and heat to 60-80°C, add 30g of taurine and 50g of vitamin B1 and stir to dissolve, set aside;

[0036] (4) Add liquid (2) and liquid (3) into liquid (1) in sequence, stir evenly, and add 5 g of benzyl alcohol. Use 10g of sodium butyrate or 10g of arginine to adjust the pH value to 7.0-8.0, and add water for injection to 1000ml;

[0037] (5) Filtered, filled with nitrogen, sealed in ampoules, sterilized by circulating st...

Embodiment 2

[0039] (1) Weigh 100g of glycerol methylal, 150g of α-pyrrolidone, and 300g of polyethylene glycol 400 (PEG400) into the batching tank, heat to 70-80°C, add 200g of polyvinylpyrrolidone while stirring, and then Add 40 g of trimethoprim, continue to stir for 10-20 minutes until dissolved, set aside;

[0040] (2) Weigh 10-20g of water for injection into a stainless steel bucket and heat to 60-80°C, add 20g of sulfamethoxine sodium and stir to dissolve, set aside;

[0041] (3) Weigh 10-20g of water for injection into a stainless steel bucket and heat to 60-80°C, add 50g of taurine and 100g of vitamin B1 and stir to dissolve, set aside;

[0042] (4) Add liquid (2) and liquid (3) into liquid (1) in sequence, stir evenly, and add 10g of benzyl alcohol. Use 20g of sodium butyrate or 20g of arginine to adjust the pH value to 7.0-8.0, and add water for injection to 1000ml;

[0043] (5) Filtered, filled with nitrogen, sealed in ampoules, sterilized by circulating steam at 100°C for 30...

Embodiment 3

[0045] (1) Weigh 80g of glycerol methylal, 120g of α-pyrrolidone, and 230g of polyethylene glycol 400 (PEG400) into the batching tank, heat to 70-80°C, add 200g of polyvinylpyrrolidone while stirring, and then Add 20 g of trimethoprim, continue to stir for 10-20 minutes until dissolved, set aside;

[0046] (2) Weigh 10-20g of water for injection into a stainless steel bucket and heat to 60-80°C, add 10g of sulfamethoxine sodium and stir to dissolve, set aside;

[0047] (3) Weigh 10-20g of water for injection into a stainless steel bucket and heat to 60-80°C, add 40g of taurine and 70g of vitamin B1 and stir to dissolve, set aside;

[0048] (4) Add liquid (2) and liquid (3) into liquid (1) in sequence, stir evenly, and add 7 g of benzyl alcohol. Use 10g of sodium butyrate or 10g of arginine to adjust the pH value to 7.0-8.0, and add water for injection to 1000ml;

[0049] (5) Filtered, filled with nitrogen, sealed in ampoules, sterilized by circulating steam at 100°C for 30 m...

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Abstract

The invention provides a long-acting compound sulfametoxydiazine sodium injection for veterinary use and a preparation method thereof. 1000ml of injection comprises the following components: 10-20g of sulfametoxydiazine, 20-40g of trimethoprim, 30-50g of taurine, 50-100g of vitamin B1, 50-100g of auxiliary material glycerinum methylal, 100-150g of alpha-pyrrolidone, 200-300g of polyethylene glycol 400 (PEG400), 150-200g of polyvinylpyrrolidone, 10-20g of sodium butyrate or 10-20g of arginine, 5-10g of benzyl alcohol, and the balance of water for injection use. According to the preparation method, the long-acting compound sulfametoxydiazine sodium injection for veterinary use is prepared by dissolving all the components into water for injection use. The long-acting compound sulfametoxydiazine sodium injection for veterinary use has the advantages of having controlled release and long-acting effects, being injected once every two days, saving manual work and cost, reducing stress increased by catching pigs and injecting, and being beneficial for ill pigs to recovery, lowering the toxic and side effects of sulfametoxydiazine in clinical application, and greatly lowering irritation to animals in injection due to the neutral pH value of the long-acting compound sulfametoxydiazine sodium injection.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, in particular to a veterinary long-acting compound sulfamethoxine sodium injection and a preparation method thereof. Background technique [0002] Sulfamethoxine sodium belongs to sulfonamide drugs, broad-spectrum antibacterial, clinically mainly used to treat piglet edema caused by sensitive bacteria, pig atrophic rhinitis, actinobacillus pleuropneumonia, piglet yellow, pullorum, pig toxoplasmosis , porcine colibacillosis, etc., clinical application is very extensive, especially for the treatment of porcine toxoplasma has special effects. [0003] The compound sulfamethoxine sodium injection prepared according to the 2010 version quality standard of "Chinese Veterinary Pharmacopoeia" has two defects in clinical application: 1. The pH value of compound sulfamethoxine sodium is 10.0-11.0, which is an alkali In a sexual environment, after the alkaline injection is injected into the anim...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/635A61K9/08A61P31/04A61K31/505A61K31/185A61K31/51
Inventor 张伟才陈国明
Owner HUBEI WUDANG ANIMAL PHARMA
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